TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection
0.050 AlteredExpression disease BEFREE TNF-α upregulation, microgliosis and upregulation of complement system proteins, C1q and C3, are induced by ZIKV infection. 31488835 2019
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection
0.050 Biomarker disease BEFREE We show that disruption of apical tight junctions by proinflammatory cytokine tumor necrosis factor alpha (TNF-α) sensitizes 3-D-cultured BBB cells to ZIKV infection and that 3-D derived BBB cells can be used to model the transmigration of ZIKV-infected monocytes across the endothelial barrier to access underlying astrocytes. 28656176 2019
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection
0.050 Biomarker disease BEFREE We found that gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α) T cell responses to NS3 differentiated DENV and ZIKV infections with 94% sensitivity and 92% specificity. 30087165 2018
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection
0.050 AlteredExpression disease BEFREE An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels. 29771234 2018
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection
0.050 Biomarker disease BEFREE Altogether, the results show that neonatal ZIKV infection has long-term neuropathological and behavioral complications in mice and suggest that early inhibition of TNF-α-mediated neuroinflammation might be an effective therapeutic strategy to prevent the development of chronic neurological abnormalities. 29875203 2018