|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis proved that TNF-α -238 and -308 G/A polymorphisms could be used to identity individual with elevated susceptibility to cervical cancer in certain populations.
|
31825934 |
2019 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to explore the association of a variant, TNF-308 G>A, residing in the TNFa gene with cervical cancer.
|
30387170 |
2019 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these results suggest that TNF-308 AA and IL10-592 CA/AA genotypes may increase susceptibility to cervical cancer by altering the immune response of an individual.
|
30453149 |
2019 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Correlation Between TNF-α Promoter Gene Polymorphism and Genetic Susceptibility to Cervical Cancer.
|
29940817 |
2018 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TNF-α was found to be downregulated at both mRNA and protein levels in CaCx cases compared to controls; and the gradient downregulation correlated with progression of the disease from normal→CIN→CaCx.
|
29608425 |
2018 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Effects of miR-195-5p/MMP14 on Proliferation and Invasion of Cervical Carcinoma Cells Through TNF Signaling Pathway Based on Bioinformatics Analysis of Microarray Profiling.
|
30355924 |
2018 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fucoxanthin and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Synergistically Promotes Apoptosis of Human Cervical Cancer Cells by Targeting PI3K/Akt/NF-κB Signaling Pathway.
|
29291370 |
2018 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, our study aimed to investigate the correlation between the polymorphism of TNF-α-308 gene and susceptibility to cervical cancer.
|
29725439 |
2018 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the role of Cx32 in extrinsic apoptosis induced by treatment with TNFα + cycloheximide (CHX) or afatinib in human cervical cancer (CaCx) cells.
|
28901517 |
2017 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that miR-126 impairs drug resistance to TRAIL, TNF-α and FasL through inhibiting the expression of c-FLIP in cervical cancer.
|
28669929 |
2017 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
There might be an association of the TLR2 and TLR4 pathways with the immunological response of TNF-α and TNF-β in cervical cancer.
|
28009429 |
2017 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) provides tumor-specific apoptosis in various cancers, including cervical cancer, the sensitivity differs depending on the cell lines.
|
27599897 |
2016 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Published data linking single nucleotide polymorphisms (SNPs) in the tumor necrosis factor-alpha (TNF-?) promoter region at positions -308G>A (rs1800629) and -238G>A (rs361525) to cervical cancer risk have been inconclusive.
|
27039819 |
2016 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Identification of genetic variants in TNF receptor 2 which are associated with the development of cervical carcinoma.
|
27145290 |
2016 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Re-expression of HPV16 E2 in SiHa (human cervical cancer) cells potentiates NF-κB activation induced by TNF-α concurrently increasing senescence and survival.
|
25572145 |
2015 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the associations between TNF-α-308G>A, -238G>A, and TNFRII - VNTR-322 and cervical cancer in Tunisian women.
|
25113639 |
2015 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess the association of TNF-α/rs1799724 and CXCL12/rs266085 polymorphisms with susceptibility to cervical cancer in Han Chinese population in Shandong Province.
|
26191295 |
2015 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis indicates that TNF-α polymorphisms may confer susceptibility to cervical cancer in an ethic-specific fashion.
|
25069725 |
2015 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF-α-induced apoptosis has been confirmed, however, relatively little is known regarding the role of forkhead box class-O 1 (FOXO1) in mediating TNF-α-induced apoptosis in cervical cancer.
|
26214423 |
2015 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, we found a significant trend for the p value, as well as the contribution of TNF-α -308 G/A to cervical cancer, in stages III and IV.
|
25614219 |
2015 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The TNF region was significantly associated with the risks of cervical cancer (gene-based p-value: 2.0 × 10(-4) ) and vulvar cancer (gene-based p-value: 1.0 × 10(-4) ).
|
23824834 |
2014 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cox multivariate analysis disclosed that carbohydrate antigen 153 (CA153), squamous cell carcinoma antigen (SCC) and tumor necrosis factor-α (TNF-α) are associated with prognosis in cervical cancer.
|
23850705 |
2013 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis suggests that TNF-α 308 G/A polymorphism is associated with increased risk of cervical cancer, and TNF-α 308 G/A mutant allele A is a risk factor of cervical cancer.
|
23494178 |
2013 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that the presence of the high producer allele TNFα-307A is associated with an increased risk for the development of cervical cancer in the Posadas population.
|
22019249 |
2012 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A comprehensive search was conducted to examine all the eligible studies of TNF-α -308 G>A polymorphism and cervical cancer risk.
|
22146770 |
2012 |