TNF, tumor necrosis factor, 7124
N. diseases: 2724; N. variants: 31
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
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0.100 | AlteredExpression | disease | BEFREE | Furthermore, the application of RSV significantly enhanced the expression of Beclin-1 and LC-3II but inhibited the serum levels of tumor necrosis factor-α and interleukin-6. | 31555372 | 2019 |
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0.100 | AlteredExpression | disease | BEFREE | Exposure to PIC and RSV significantly lowered hepatic levels of tumor necrosis factor-alpha. | 31268397 | 2019 |
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0.100 | AlteredExpression | disease | BEFREE | We initially discovered that RSV significantly improved cardiac function and suppressed the expression of fibrosis markers, such as collagen-I, collagen-III, and fibronectin, and pro-inflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). | 31497235 | 2019 |
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0.100 | Biomarker | disease | BEFREE | Other host factors that correlate with severe RSV disease include high concentrations of proinflammatory cytokines such as interleukins (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and thymic stromal lymphopoitein (TSLP), which are produced in the respiratory tract of RSV-infected individuals, accompanied by a strong neutrophil response. | 31572372 | 2019 |
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0.100 | Biomarker | disease | BEFREE | We have previously implicated activation of pulmonary macrophage by TNF-α and/or MCP-1 in the mechanisms of RSV-induced exacerbation. | 29167232 | 2018 |
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0.100 | Biomarker | disease | BEFREE | In the present study, truncated G protein was successfully expressed both in prokaryotic and eukaryotic system, and high levels of serum IgG in response to truncated G protein were observed both in GD-protein group (intramuscularly with purified GD protein) and GD-VNP20009 group (challenged via the oral route with 1 × 10<sup>9</sup> CFU of pLIVE-RSV-GD-VNP20009 strains) since 21th day, and GD-VNP20009 significantly reduced the productions of IL-1β, IL-6, and TNF-α, histamine and pathological features caused by the RSV Long strain (P < .01). | 29306006 | 2018 |
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0.100 | AlteredExpression | disease | BEFREE | In contrast, the F VLP-immune mice induced protection against RSV without disease by inducing natural killer cells, activated IFN-<i>γ</i><sup>+</sup>, and IFN-<i>γ</i><sup>+</sup> tumor necrosis factor (TNF)-<i>α</i><sup>+</sup> CD8<sup>+</sup> T cells in the lung and bronchiolar airways during RSV infection but not disease-inducing DCs and effector T cells. | 29302248 | 2017 |
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0.100 | Biomarker | disease | BEFREE | OSC suppressed the RSV-increased production and release of pro-inflammatory cytokines and chemokines [tumor necrosis factor-α, interleukin-6 (IL-6), IL-8, regulated on activation in normal T-cell expressed and secreted, macrophage inflammatory protein-1α; and monocyte chemoattractant protein-1] in A549 cells. | 28979683 | 2017 |
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0.100 | Biomarker | disease | BEFREE | These mediators include classical pro-inflammatory cytokines such as TGF-β, TNF-α, interferons, or IL-1β that are released upon bacterial challenge with <i>Streptococcus pneumoniae, Klebsiella pneumoniae</i>, or <i>Mycoplasma pneumoniae</i> as well as in viral infection with influenza A virus, pathogenic coronaviruses, or respiratory syncytial virus. | 28458673 | 2017 |
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0.100 | Biomarker | disease | BEFREE | A Th1-type immune response was indicated by a high IgG2a/IgG1 ratio of RSV-specific antibodies, strong induction of RSV-specific interferon-gamma and tumor necrosis factor-alpha cytokine producing CD8 Tcells, and low RSV-specific CD4 T-cell induction. | 26319741 | 2015 |
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0.100 | Biomarker | disease | BEFREE | IFN-α produced by A549 cells after RSV or hMPV infection remained undistinguishable, whereas production of TNF-α was significantly higher after RSV infection than hMPV infection either in the presence or absence of Poly I:C. This study provides a clue that more severe clinical syndrome of RSV infection may be due to the greater magnitude of induction of airway inflammation by RSV involving TLR3 activation and production of TNF-α. | 24039959 | 2013 |
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0.100 | Biomarker | disease | BEFREE | We first found that the expression and barrier function of tight junction molecules claudin-4 and occludin were markedly induced together with production of proinflammatory cytokines interleukin 8 and tumor necrosis factor-α in HNECs after RSV infection, and the induction of tight junction molecules possibly contributed to budding of RSV. | 21562222 | 2011 |
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0.100 | AlteredExpression | disease | BEFREE | Pretreatment with rhVEGF increased mRNA expression of SP-A, SBD-1, and TNFα, with alteration of expression in RSV lambs. | 21309731 | 2011 |
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0.100 | GeneticVariation | disease | BEFREE | In contrast, RSV bronchiolitis was associated with TNF haplotypes (p < 0.00001) but not with any single polymorphism. | 18811622 | 2009 |
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0.100 | Biomarker | disease | BEFREE | The concentration of IL-10 (p=0.04) and TNF-alpha (p=0.006) in the RSV-positive group was significantly higher than in the hBoV-positive group, while there was no difference in other cytokines concentration between the two groups. | 18650126 | 2008 |
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0.100 | AlteredExpression | disease | BEFREE | The increase in RSV replication and TNF-alpha expression after TGF-beta treatment was concomitant with an increase in virus-induced p38 mitogen-activated protein kinase activation. | 17202225 | 2007 |
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0.100 | Biomarker | disease | BEFREE | In the second set of experiments, cytokines were also measured after TNF-alpha stimulation in both RSV-infected and uninfected cultures. | 15867636 | 2005 |
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0.100 | GeneticVariation | disease | BEFREE | No significant associations of TNF-alpha and IL-9 polymorphisms with RSV bronchiolitis were observed. | 14722888 | 2004 |
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0.100 | Biomarker | disease | BEFREE | To test this hypothesis we compared immunoreactive IL-8 release by primary nasal epithelial cell (NEC) cultures established from young children with or without CF, at several time points after stimulation of cultures with tumor necrosis factor-alpha (TNF-alpha) or infection with respiratory syncytial virus (RSV). | 9698592 | 1998 |
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0.100 | GeneticVariation | disease | BEFREE | Investigations concerning the severity of respiratory syncytial virus (RSV) disease as related to (1) RSV type and genotype determined respectively by PCR and restriction enzyme analysis and (2) interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) values in samples of nasopharyngeal secretion (NPS) have not been previously reported. | 9877358 | 1998 |
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0.100 | AlteredExpression | disease | BEFREE | Preincubation with neutralizing antibodies to IL-1 alpha and -beta, and TNF-alpha showed that the predominant ICAM-1 enhancing soluble mediator in UV-cRSV was IL-1 alpha. | 7576697 | 1995 |
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0.100 | AlteredExpression | disease | BEFREE | All samples with the RSV genome contained the mRNA for interleukin-1 beta and -6 and tumor necrosis factor-alpha. | 8228363 | 1993 |
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0.100 | AlteredExpression | disease | BEFREE | Despite the high levels of cytokines with possible antiviral activity (TNF and IL-6) in the AM supernatants, neither supernatants nor rTNF when added to bronchial epithelial cells protected them from infection with RSV. | 1753101 | 1991 |