TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Disease: Oestrogen deficiency ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.100 Biomarker disease BEFREE Several lines of evidence have suggested tumor necrosis factor (TNF) as a mediator of vascular dysfunction associated with estrogen deficiency. 30630756 2019
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.100 AlteredExpression disease BEFREE However, pretreatment with Melo had no effects on ALT levels and the gene expression levels of TNF-α, IL-6 and HO-1 in either sham or ovx mice, indicating that cox-2 may not participate in increase of CCl<sub>4</sub>-induced ALI caused by estrogen deficiency. 29787990 2018
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.100 Biomarker disease BEFREE TNF-α suppresses osteogenic differentiation of MSCs by accelerating P2Y<sub>2</sub> receptor in estrogen-deficiency induced osteoporosis. 30236554 2018
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.100 AlteredExpression disease BEFREE Here, we identified a novel mechanism whereby TNF-α increasing Semaphorin3D expression contributes to estrogen deficiency-induced osteoporosis. 28059444 2017
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.100 AlteredExpression disease BEFREE ALA (100 and 300 mg/kg) intervention to estrogen-deficiency induced bone loss mice (ovariectomized) showed reductions in TRAP+ osteoclasts count, CTX-I expression, levels of IL-1β, IL-2, IL-6, IL10, TNF-α and MCP-1 and iNOS and COX-2. 29061958 2017
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.100 AlteredExpression disease BEFREE In vitro studies indicate that estrogen deficiency and high glucose enhance TNF-α expression in response to inflammatory signals. 28419209 2017
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.100 Biomarker disease BEFREE The decline of FoxO1 protein was caused by tumor necrosis factor-alpha (TNF-α) accumulated after estrogen deficiency. 26700816 2016
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.100 Biomarker disease BEFREE Finally, TNFα or IL-1, which are osteoclastogenic cytokines overproduced in the bone marrow under estrogen deficiency, can activate p38α signaling in osteoblasts, but those cytokines cannot enhance Rankl and Il6 expressions or increase osteoclast formation in p38a-deficient osteoblast cultures. 26441240 2015
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.100 Biomarker disease BEFREE Estrogen deficiency in ArKO mice was associated with significant increases in LPS-induced serum interleukin-6 (IL-6), tumor necrosis factor, monocyte chemotactic protein 1, and interferon-gamma levels, which were significantly abrogated by administration of 16alpha-LE2, but not 8beta-VE2. 20131258 2010
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.100 Biomarker disease BEFREE The finding that estrogen deficiency was associated with increased production of cytokines led to a barrage of studies and lively debate on the relative contributions of TNF and other cytokines on bone loss, on the potential cell sources of TNF in the bone microenvironment, and on the mechanism of TNF action. 14636987 2003