|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Serum biomarkers of ED (sVCAM-1, E-selectin, P-selectin, thrombomodulin, sICAM-1, sICAM-3) and LGI (hs-CRP, SAA, IL-6, IL-8, TNF-α) were measured with a single- or multiplex array detection system based on electro-chemiluminescence technology.
|
31518378 |
2019 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Impressic Acid, a Lupane-Type Triterpenoid from <i>Acanthopanax koreanum</i>, Attenuates TNF-α-Induced Endothelial Dysfunction via Activation of eNOS/NO Pathway.
|
31744135 |
2019 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The HIV-1-proteins Tat, Gp120 and Nef in particular, the proinflammatory cytokine, TNF-α, and the antiretroviral drugs Efavirenz and Lopinavir, most commonly postulated to be primary causal agents of endothelial dysfunction, are also discussed.
|
30220106 |
2019 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, the effects of miR-29a-3p on endothelial dysfunction were assessed in C57BL/6 mice injected with TNFα and/or a miR-29a-3p agomir.
|
31760375 |
2019 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Serum concentrations of inflammatory markers (tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), interleukin 1β (IL-1β), C-reactive protein (CRP)) and biomarkers of endothelial dysfunction (vascular cell adhesion molecule-1 (VCAM-1) and asymmetric dimethylarginine (ADMA)) were measured by ELISA.
|
31712060 |
2019 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Pro-inflammatory T cell-derived cytokines such as IFN-γ and TNF-α (from CD8+ and CD4+Th1) and IL-17A (from the γδ-T cell and CD4+Th17) exacerbate hypertensive responses mediating both endothelial dysfunction and cardiac, renal, and neurodegenerative injury.
|
31321561 |
2019 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The aims of this study were to investigate whether and how combined curcumin and luteolin synergistically inhibit tumor necrosis factor-alpha (TNF-α)-induced monocytes adhesion endothelium, a crucial step of the development of endothelial dysfunction, both in human vascular cells and mouse aortic endothelium.
|
31665675 |
2019 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Non-TNF-targeted biologics have been associated with favorable effects on endothelial dysfunction as already demonstrated for TNF inhibitors.
|
30844558 |
2019 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Expression level of multiple markers implicated in inflammation (tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10; metalloproteinase MMP-9) and markers of endothelial dysfunction (I-CAM and V-CAM) was determined from lung tissues mRNA using RT-PCR.
|
30056108 |
2018 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This study provides novel evidence that TNFα leads to endothelial dysfunction associated with hypertension and vascular remodeling in preeclampsia through down-regulation of endothelial nitric-oxide synthase (eNOS) by NF-κB-dependent biogenesis of microRNA (miR)-31-5p, which targets eNOS mRNA.
|
30279269 |
2018 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Unbiased hierarchical clustering identified five different clusters of sepsis mediators, including one with markers of platelet activation (e.g., thrombospondin-1) positively associated with platelet count, one with markers of inflammation (e.g., tumor necrosis factor alpha and heat shock protein 70), and endothelial dysfunction (e.g., intercellular adhesion molecule-1 and vascular cell adhesion molecule-1) negatively associated with platelet count, and another involving growth factors of thrombopoiesis (e.g., thrombopoietin), also negatively associated with platelet count.
|
29028771 |
2018 |
|
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In contrast, DMY or blockade of miR-21 expression ameliorated endothelial dysfunction in HUVECs treated with TNF-<i>α</i> through downregulation of miR-21 expression, whereas these effects were abolished by overexpression of miR-21.
|
29682517 |
2018 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Protective Role of Antioxidant Huskless Barley Extracts on TNF-<i>α</i>-Induced Endothelial Dysfunction in Human Vascular Endothelial Cells.
|
29861828 |
2018 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Plasma samples (0, 30, 60, 90, 120min post-glucose administration) were analyzed for triglycerides; hormones involved in glucose regulation (insulin, glucagon, glucagon-like peptide (GLP)-1)), energy homeostasis (ghrelin, leptin), and stress response (corticosterone); cytokines (TNF, IL-6); and markers of endothelial dysfunction (VEGF, PAI-1).
|
29103948 |
2018 |
|
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We examined the ability of metformin + esomeprazole to rescue TNF-α induced vascular cell adhesion molecule-1 (VCAM-1) and Endothelin-1 (ET-1) expression, leukocyte adhesion (markers of endothelial dysfunction).
|
29466360 |
2018 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The results of the present study demonstrated that TNF‑α was able to induce vascular endothelial dysfunction in Eahy926 cells at an optimum concentration of 10 ng/ml.
|
29956764 |
2018 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this study, we investigated the role of receptor interacting protein 1 (RIP1), one of the kinases involved in apoptosis and necroptosis mediated by the death receptor tumor necrosis factor receptor (TNFR), in endothelial dysfunction.
|
30372886 |
2018 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We performed in vitro assays to assess whether melatonin 1) enhances the antioxidant response element genes (heme-oxygenase 1, (HO-1), glutamate-cysteine ligase (GCLC), NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), thioredoxin (TXN)) or 2) alters secretion of the anti-angiogenic factors soluble fms-like tyrosine kinase-1 (sFLT) or soluble endoglin (sENG) from human primary trophoblasts, placental explants and human umbilical vein endothelial cells (HUVECs) and 3) can rescue TNF-α induced endothelial dysfunction.
|
29641523 |
2018 |
|
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
DJC therapy exhibited a potent antioxidant activity and effectively prevented the endothelial dysfunction (ED) manifested by promoting p-eNOS expression and enhancing NO release, decreasing lipid deposition (Oil-red O staining, CPT1b and ACC) and inflammation (IL-1β, TNFα, CD68 and p-JNK), alleviating oxidative and ER stress, and decreasing the apoptosis of endothelial cells (TUNEL, BCL-2 and BAX) induced by HFD and palmitic acid respectively.
|
30257381 |
2018 |
|
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
At conditions of endothelial dysfunction (ED), RES reduced the expression of cytokines, chemokines, ICAM and GM-CSF in TNF-α activated HUVECs, whereas eNOS expression was corrected to pre-ED homeostasis.
|
28610607 |
2017 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To date, there is no clear evidence that HO-1/CO prevents endothelial dysfunction associated with the downregulation of endothelial NO synthesis in human endothelial cells stimulated with TNF-α.
|
29170479 |
2017 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The aim of the study was to assess the determinants of FGF21, the correlation between FGF21 and tumor necrosis factor TNF-like weak inducer of apoptosis (sTWEAK) and the correlation between FGF21 and endothelial dysfunction in HD patients.
|
27943169 |
2017 |
|
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These findings demonstrated for the first time that BBR could prevent the oxLDL and TNFα - induced LOX1 expression and oxidative stress, key events that lead to NOX, MAPK/Erk1/2 and NF-κB activation linked to endothelial dysfunction.
|
28511903 |
2017 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
C1q/TNF-Related Protein-9 Ameliorates Ox-LDL-Induced Endothelial Dysfunction via PGC-1α/AMPK-Mediated Antioxidant Enzyme Induction.
|
28587104 |
2017 |
|
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Aspirin rescued TNF-α-mediated eNOS downregulation coupled with endothelial dysfunction by inhibiting NF-κB-dependent transcriptional miR-155 biogenesis.
|
28087411 |
2017 |