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TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TNF receptor-associated periodic fever syndrome (TRAPS) is an autosomal dominant systemic autoinflammatory disease caused by mutations of TNF receptor superfamily member 1 A (TNFRSF1A) gene.
|
31774538 |
2019 |
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TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this review, I will discuss the most common autoinflammatory conditions of adulthood including familial Mediterranean fever (FMF), cryopyrin-associated periodic syndrome (CAPS), mevalonate kinase deficiency/hyperimmunoglobulinemia D Syndrome (MKD/HIDS), TNF receptor-associated autoinflammatory syndrome (TRAPS), and systemic juvenile idiopathic arthritis/adult-onset Still's disease (SJIA/AOSD).
|
30394352 |
2019 |
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TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autoinflammatory disease that is caused by heterozygous mutations in the TNFRSF1A gene.
|
31429073 |
2019 |
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TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stimulation of PBMCs with TLR-9 ligand (ODN2006) triggered significantly greater up-regulation of proinflammatory signalling intermediates [TNF receptor-associated factor (TRAF 3), IL-1 receptor-associated kinase-like 2 (IRAK2), Toll interacting protein (TOLLIP), TRAF6, phosphorylated transforming growth factor-β-activated kinase 1 (pTAK), transforming growth factor-β-activated kinase-binding protein 2 (TAB2), phosphorylated TAK 2 (pTAB2), IFN-regulatory factor 7 (IRF7), receptor interacting protein (RIP), nuclear factor kappa B (NF-κB) p65, phosphorylated NF-κB p65 (pNF-κB p65) and mitogen-activated protein kinase kinase (MEK1/2)] in TRAPS patients' PBMCs.
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31009059 |
2019 |
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TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
RNAi targeting PKC-α inhibited TNF-α-induced IP<sub>3</sub>R1 overexpression and in turn improved compromised GFR in the development of acute kidney injury during FHF in rats.
|
29357415 |
2018 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Canakinumab downregulated the TRAPS-causing gene (TNF super family receptor 1A (TNFRSF1A)), the drug-target gene (interleukin (IL)-1B) and other inflammation-related genes (eg, MAPK14).
|
27474763 |
2017 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TNF receptor associated periodic syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1).
|
28860008 |
2017 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is a multisystemic autoinflammatory condition associated with heterozygous TNFRSF1A mutations, presenting with a variety of clinical symptoms, many of which yet unexplained.
|
27310036 |
2017 |
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TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggested that AA treatment effectively protected against LPS/d-GalN-induced FHF by lessening the lethality; decreasing the alanine transaminase and aspartate aminotransferase levels, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α production, malondialdehyde formation, myeloperoxidase level and reactive oxygen species generation (i.e., H<sub>2</sub>O<sub>2</sub>, NO, and [Formula: see text]), and increasing the glutathione and superoxide dismutase contents.
|
28736552 |
2017 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor receptor-associated periodic syndrome is associated with mutations in the tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) gene which decreases the level of soluble tumor necrosis factor receptor-1 (TNFR1) leading to neutralization of tumor necrosis factor (TNF)-α.
|
27187378 |
2016 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HEK-293 and SK-HEP-1 cell lines were stably transfected with WT or TRAPS-associated variants of human TNF receptor superfamily 1A gene.
|
26202849 |
2015 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS).
|
24668260 |
2014 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS), formerly known as familial Hibernian fever, is the most common autosomal dominant autoinflammatory disease, resulting from mutations in the TNFRSF1A gene, encoding the 55-kD tumor necrosis factor receptor.
|
24935411 |
2014 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Downregulation of autophagy enhances the inflammatory response and thus represents a possible common pathogenic event underlying a number of autoinflammatory syndromes, such as tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS).
|
24706103 |
2014 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is caused by TNFRSF1A mutations, known to induce intracellular retention of the TNFα receptor 1 (TNFR1) protein, defective TNFα-induced apoptosis, and production of reactive oxygen species.
|
23117241 |
2013 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal dominantly inherited rare autoinflammatory disease.
|
20532935 |
2013 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-TNF therapy in TRAPS has been based on etanercept, a recombinant human TNFR (p75)-Fc fusion protein comprising two receptors linked by an IgG(1) Fc fragment.
|
22884554 |
2012 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies on the pathogenesis of TRAPS have shown TNFα-dependent cellular signalling to be defective, an enigmatic finding considering the hyperinflammatory phenotype of the disease.
|
21284532 |
2012 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Familial Mediterranean fever (FMF), mevalonate-kinase deficiency (MKD) and tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) are the three monogenic disorders subsumed under the term periodic fevers, while a systemic inflammation dominated by a characteristic urticarial rash associated with a number of other clinical manifestations is typical of familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurological cutaneous and articular syndrome (CINCA).
|
22714396 |
2012 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant autoinflammatory condition caused by mutations in the TNFRSF1A gene which encodes the tumor necrosis factor (TNF) receptor, TNFR1.
|
21420073 |
2011 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Role of tumour necrosis factor (TNF)-α and TNFRSF1A R92Q mutation in the pathogenesis of TNF receptor-associated periodic syndrome and multiple sclerosis.
|
22059991 |
2011 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal-dominant multisystemic autoinflammatory condition.
|
21459945 |
2011 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification of TNFRSF1A mutations as the genetic cause of TRAPS coincided with the wider use of biological agents in medicine and raised the possibility that blocking TNF could potentially represent the primary therapeutic goal in TRAPS, thus disclosing new treatment choices for this complex disease.
|
20943039 |
2010 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that SNPs at -308 and -857 of the TNFalpha promoter may represent an increased risk for the development of AVH but not for FHF in the Indian population.
|
19390969 |
2010 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the three families studied, TRAPS was associated with low TNF-mediated signalling in leucocytes.
|
20071450 |
2010 |