|
Cancer cachexia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lastly, BPC 157 counteracts tumor cachexia, muscle wasting, and increases in pro-inflammatory/procachectic cytokines, such as interleukin-6 and tumor necrosis factor-α, and significantly corrects deranged muscle proliferation and myogenesis through changes in the expression of FoxO3a, p-AKT, p-mTOR, and P-GSK-3β (mitigating cancer cachexia).
|
31158953 |
2020 |
|
Cancer cachexia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among potential molecular alterations related to cancer cachexia, there are single-nucleotide polymorphisms (SNPs) within genes encoding pro-inflammatory cytokines such as TNF-α.
|
29802455 |
2018 |
|
Cancer cachexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α, have been correlated with CC; however, its prognostic significance remains unclear.
|
30513776 |
2018 |
|
Cancer cachexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chronic inflammation, mediated by cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), has been reported to promote cancer cachexia.
|
29338749 |
2018 |
|
Cancer cachexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF-α and cancer cachexia: Molecular insights and clinical implications.
|
27919820 |
2017 |
|
Cancer cachexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The possible mechanisms were studied both in a colon 26-induced cancer cachexia mouse model and in tumor necrosis factor-α (TNF-α) induced atrophy C2C12 cells.
|
25760630 |
2015 |
|
Cancer cachexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied gene, protein expression and activity of the main enzymes involved in CL metabolism in liver mitochondria from a rat model of cancer cachexia and in HepaRG hepatocyte-like cells exposed to 20 ng/ml of TNFα for 12 h. Phosphatidylglycerolphosphate synthase (PGPS) gene expression was increased 2.3-fold (p<0.02) and cardiolipin synthase (CLS) activity decreased 44% (p<0.03) in cachectic rat livers compared to controls.
|
26327596 |
2015 |
|
Cancer cachexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several biochemical pathways can lead to cancer cachexia, one of which involves the elevation of the cytokines, such as tumor necrosis factor alpha (TNF-alpha) and interferon gamma (INF-gamma).
|
19152246 |
2009 |
|
Cancer cachexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two of these five patients with normal TNF levels each had a weight gain of more than 5% after 3 weeks of pentoxifylline therapy suggesting that, although TNF may be important in the pathogenesis of cancer cachexia, other anorexia-producing cytokines that are potentially affected by pentoxifylline may also be involved.
|
7678547 |
1993 |
|
Cancer cachexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the cytokine cascade, a central position is occupied by that molecule known as "cachectin" or "tumor necrosis factor," because this molecule, more than any other, has been shown to mediate the biologic effects of LPS, and to provoke a state of wasting very similar to that observed in cancer cachexia.
|
2650822 |
1989 |