|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Advanced-stage breast tumors have a high concentration of tumor necrosis factor-α (TNFα) throughout the tumor/stroma milieu, prompting sustained release of diverse chemokines (i.e.
|
31659097 |
2020 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Studies with MSCs activated by TNFα + TGFβ1 revealed that they release factors that can affect other cells in their microenvironment and induce breast tumor cell elongation, migration, and scattering out of spheroid tumor masses.
|
28553282 |
2017 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
TNFα acts on breast tumor TNF receptors evoking the release of chemotactic proteins (e.g.MCP-1/CCL2).
|
28441391 |
2017 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we reveal a strong positive correlation between expression of HOXA1 and of members of the TNF/NF-κB pathway in breast tumor datasets.
|
27382069 |
2016 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Exposure of MSCs to TNF-α led to potent CCL2-induced migration of monocytic cells, a process that may yield pro-cancerous myeloid infiltrates in breast tumors.
|
25928089 |
2015 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
ONO-8430506 also decreased plasma TNF-α and G-CSF cytokine levels by >70% and leukocyte infiltration in breast tumors and adjacent adipose tissue by >50%.
|
26071407 |
2015 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Through search for other possible p53 E3 ligases by mRNA and protein expression analysis, downregulation of TNF receptor-associated factor 7 (TRAF7) expression was found in these breast tumors.
|
23128672 |
2013 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
We found a significant positive correlation between TNF and the majority (85 %) of the identified endothelial TNF-induced genes in a well-defined series of 96 (48 ERα positive and 48 ERα negative) breast tumors.
|
21754991 |
2011 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, genes positively regulated by E(2) + TNFalpha are clinically relevant because they are enriched in luminal B breast tumors and their expression profiles can distinguish a cohort of patients with poor outcome following endocrine treatment.
|
19920189 |
2009 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients.
|
19446661 |
2009 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and canstatin gene suppression therapy on breast tumor xenograft growth in mice.
|
17899369 |
2008 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
TNF alpha-induced down-regulation of estrogen receptor alpha in MCF-7 breast cancer cells.
|
18483465 |
2008 |
|
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk.
|
17216494 |
2007 |
|
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
[Polymorphisms of tumor necrosis factor genes in sporadic and hereditary breast cancer].
|
18416134 |
2007 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q(10), riboflavin and niacin.
|
17516992 |
2007 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Mutant TNFalpha negatively regulates human breast cancer stem cells from MCF7 in vitro.
|
17881900 |
2007 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The purpose of the present study was to study the aromatase mRNA expression as well as promoter usage (I.4, I.3, PII and I.7) in axillary adipose tissue (AA), mammary adipose tissue (MA), breast tumor tissue (BT) and adjacent normal breast tissue (NB), and to study the relationship between aromatase mRNA expression and tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and cyclooxygenase (COX)-2 mRNA expression.
|
16287071 |
2006 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Tumor necrosis factor receptor associated factor 4 (Traf4) mRNA expression is upregulated in various breast tumors and tumor cell lines.
|
16969126 |
2006 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis.
|
16114000 |
2005 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases.
|
15044327 |
2004 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Induction of tumor necrosis factor expression and resistance in a human breast tumor cell line.
|
3476961 |
1987 |