|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The mechanisms exploration revealed that MENK (10 mg/mL) significantly inhibited the nucleoprotein (NP) of influenza virus and up-regulated levels of IL-6, TNF-α and IFN-β compared with those in H1N1 control group.
|
31835089 |
2020 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the case of full length SP-A treatment, mRNA expression levels of TNF-α and IL-6 were downregulated during the mid-to-late stage of IAV infection of A549 cells.
|
30954271 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified that mediators implicated in the pathogenesis of IAV infection including interferons (IFNs), TNFα, and agonists for Toll-like receptors 3 and 4 were potent inducers of ZBP1 expression in primary murine alveolar epithelial cells, bone marrow derived macrophages, and dendritic cells.
|
31440477 |
2019 |
|
Influenza A
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that SNPs in the IL10 and TNFA genes might be associated with disease severity in influenza A/H1N1pdm09-infected patients.
|
30475169 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of the older adults who became infected with influenza, a high IL-10 and iGrB response in virus-challenged cells was observed post-infection (week 10 to 20), as well as IFN-γ and TNF-α at week 20.
|
28958701 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study investigated the effect of celastrol on mRNA expression and concentration levels of the pro-inflammatory cytokines tumor necrosis factor alpha (TNFα) and interleukin-6 (IL6) that are induced by influenza A/Puerto Rico/8/34 (H1N1; PR8) in Madin-Darby Canine Kidney (MDCK) cells.
|
29493374 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
These mediators include classical pro-inflammatory cytokines such as TGF-β, TNF-α, interferons, or IL-1β that are released upon bacterial challenge with <i>Streptococcus pneumoniae, Klebsiella pneumoniae</i>, or <i>Mycoplasma pneumoniae</i> as well as in viral infection with influenza A virus, pathogenic coronaviruses, or respiratory syncytial virus.
|
28458673 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, TNF exerts an immunoregulatory role on CD8+ T cell responses following IAV infection, an effect that is largely mediated by extrinsically-derived TNF.
|
28886201 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Animal and in vitro models of acute lung injury were used to characterize KLF2 expression and its downstream effects responding to influenza A virus (A/WSN/33 [H1N1]), tumor necrosis factor-α, LPS, mechanical stretch/ventilation, or microvascular flow.
|
27855271 |
2017 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The use of 2-methoxyestradiol (2ME2), a HIF-1α inhibitor that blocks HIF-1α nuclear accumulation, in H1N1-infected cells decreased the mRNA and protein expression of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6 and increased the levels of IL-10.
|
28536432 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to immune and inflammation regulatory pathways, like intestinal immune network for IgA production, cytokine-cytokine receptor interaction, Ras signaling pathway, allograft rejection and hematopoietic cell lineage, KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analyses revealed that infection-associated pathways (influenza A and toxoplasmosis) and metabolism-associated pathways were involved in response to TNF-α inhibitor treatment, providing insight into the mechanism of TNF-α inhibitors.
|
28835680 |
2017 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that both 2009 pandemic H1N1 influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus induce expression of tumor necrosis factor α, interleukin-6, and interleukin-8 in the respiratory tract and central nervous system.
|
28973159 |
2017 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Most patients infected with the influenza A (H1N1) pdm09 virus had increased systemic levels of pro-inflammatory cytokines; including interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α).
|
26657940 |
2015 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Transfection of influenza A virus nuclear export protein induces the expression of tumor necrosis factor alpha.
|
24657783 |
2014 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
There was a correlation between hyperediting of influenza A viral ssRNA and its ability to stimulate TNF-α, independent of 5'-triphosphate residues, and involving Adar-1.
|
24227841 |
2014 |
|
Influenza A
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that the influenza A(H1N1)pdm09 patients and healthy controls have different profiles of immune parameters and that there is an association between IL-10 and TNFα polymorphisms and the outcome of this disease.
|
23809475 |
2013 |
|
Influenza A
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Role of tumor necrosis factor gene single nucleotide polymorphisms in the natural course of 2009 influenza A H1N1 virus infection.
|
22269998 |
2012 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, in comparison to seasonal H1N1 virus, H5N1 infection elicits a quantitatively stronger host inflammatory response including type I interferon (IFN) and tumor necrosis factor (TNF)-alpha genes.
|
20011590 |
2009 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha production of influenza A virus-infected macrophages and potentiating effect of lipopolysaccharides.
|
2391423 |
1990 |