|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) dependent apoptosis has been implicated in CD4 T-cell death and immunologic control of HIV-1 infection.
|
31149947 |
2019 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transfection of CD4- 293T cells with a cDNA expression library developed from a podocyte cell line derived from a child with HIVAN led to the identification of TNF-<i>α</i> as a possible mediator of HIV-1 infection.
|
27811066 |
2017 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A hallmark of HIV-1 infection is immune activation and inflammation with increased levels of TNF in the plasma and the tissues.
|
28358311 |
2017 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Plasma concentrations of TGF β 1 and IL-10 were significantly decreased while IL-1β, IL-12p70 and TNF-α were increased in patients with non-progressive HIV-1 infection compared to patients with progressive infection.
|
26986868 |
2016 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
B-cell dysfunction was examined in patients with HIV-1 infection (n = 30) who had received ART for a median time of 9.25 years (range: 1.3-21.7) by assessing proportions of CD21 B cells (a marker of B-cell exhaustion) and proportions of tumor necrosis factor-related apoptosis-inducing ligand or B and T lymphocyte attenuator B cells, and serum levels of immunoglobulin free light chains (markers of B-cell hyperactivation).
|
26914910 |
2016 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The novel genetic associations between allelic variants of genes TNF-α-238 and PDCD1-7209 with the LTNP condition underline the importance of host genetic factors in the progression of HIV-1 infection and in immunological preservation.
|
23403273 |
2013 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Yet, because of the important role played by TNFα in HIV-1 infection, and given the proximity of the -237 SNP to the core promoter, its location within a putative repressor region previously characterized in mice, and its disruption of a methylation-susceptible CpG dinucleotide motif, we chose to carefully evaluate its impact on TNFα production.
|
22808100 |
2012 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor alpha (TNF-α) is thought to be involved in the pathogenic and metabolic events associated with HIV-1 infection.
|
20854131 |
2011 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The function of plasmacytoid dendritic cells (PDC) in chronic human immunodeficiency virus type 1 (HIV-1) infection remains controversial with regard to its potential for sustained alpha interferon (IFN-alpha) production and induction of PDC-dependent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity of HIV-infected cells.
|
20042498 |
2010 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to determine whether carriage of the TNF-alpha-238G>A, -308G>A and -863 C>A gene promoter single nucleotide polymorphisms (SNP) and the CCR5 Delta 32 variant allele influence the risk of HIV-1 infection and disease progression in Caucasian Spaniards.
|
20420684 |
2010 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
While this short NF-kappaB peak potently reactivated latent HIV-1 infection, it failed to induce gene expression of several proinflammatory NF-kappaB-dependent cellular genes, such as those for tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8), and gamma interferon (IFN-gamma).
|
20538859 |
2010 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The increase in the mRNA amounts for the former two genes may be due to the action of tumour necrosis factor-alpha (TNF-alpha), a cytokine with enhanced expression in adipose tissue following HIV-1 infection, as the effect is also observed in human adipocytes in culture after treatment with TNF-alpha.
|
17926640 |
2007 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF synthesis in placental cells is induced by HIV-1 infection that, in an autocrine manner, activates viral replication, because neutralizing anti-TNF antibodies block it.
|
17396998 |
2007 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This RaSH approach has previously documented high sensitivity and effectiveness in identifying genes that are differentially expressed as a function of induction of terminal differentiation in human melanoma cells, resistance or sensitivity to human immunodeficiency virus-1 (HIV-1) infection of human T cells and perturbation in gene expression in normal human fetal astrocytes infected with HIV-1 or treated with HIV-1 gp120 viral envelope glycoprotein or tumor necrosis factor-alpha (TNF-alpha).
|
15563845 |
2004 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistently, the addition of CC-3052 reduced TNF-alpha production in phytohaemagglutinin (PHA) and lipopolysaccharide (LPS)-stimulated whole blood cultures from patients during the primary acute phase of HIV-1 infection.
|
10606973 |
2000 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tumor necrosis factor alpha (TNF-alpha) is one candidate neurotoxin and is upregulated during HIV-1 infection of the brain, likely via activation of the transcription factor NF-kappaB.
|
10229115 |
1999 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Functional analysis of lymphocytes from the seronegative group revealed no difference in endogenous or mitogen-induced TNF-alpha production, as well as susceptibility to in vitro HIV-1 infection between different TNF-genotype donors.
|
9519891 |
1998 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Soluble CD30, tumour necrosis factor (TNF)-alpha, and TNF receptors in primary HIV-1 infection: relationship with HIV-1, RNA, clinical outcome and early antiviral therapy.
|
9418161 |
1998 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of this study do not point toward a role for known TNF-alpha G to A transition polymorphisms in the clinical course of HIV-1 infection.
|
8985218 |
1997 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma levels of soluble CD30, tumour necrosis factor (TNF)-alpha and TNF receptors during primary HIV-1 infection: correlation with HIV-1 RNA and the clinical outcome.
|
8931778 |
1996 |