TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Disease: Autoinflammatory disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 Biomarker disease BEFREE Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autoinflammatory disease that is caused by heterozygous mutations in the TNFRSF1A gene. 31429073 2019
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 Biomarker disease BEFREE TNF receptor signalling in autoinflammatory diseases. 30838383 2019
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 Biomarker disease BEFREE An increasing body of evidence supports the role of pro-inflammatory cytokines like interleukin (IL)-1-beta, IL-17 and tumour necrosis factor (TNF)-alpha in the pathophysiology of neutrophilic diseases similarly to classic monogenic autoinflammatory diseases, suggesting common physiopathological mechanisms. 28688013 2018
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 GeneticVariation disease BEFREE TNF receptor associated periodic syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1). 28860008 2017
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 Biomarker disease BEFREE Pro-inflammatory cytokines such as IL-1β, IL-6 and TNF-α are central regulators of autoinflammatory diseases. 27550296 2017
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 GeneticVariation disease BEFREE Gene set disease association analysis revealed that eQTLs for genes in the TNF superfamily pathway were associated with six of the eight autoimmune and autoinflammatory diseases examined, demonstrating associations beyond single genome-wide significant hits. 27435189 2016
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 Biomarker disease BEFREE Although a group of patients exhibit episodic systemic inflammation (periodic fevers), these disorders are mediated by continuous overproduction and release of pro-inflammatory mediators, such as IL-1 and IL-6, and TNF and are best considered as autoinflammatory diseases rather than periodic fevers. 24831056 2014
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 Biomarker disease BEFREE Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal dominantly inherited rare autoinflammatory disease. 20532935 2013
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 Biomarker disease BEFREE Tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is a dominantly inherited autoinflammatory disease caused by heterozygous mutations in the TNFRSF1A gene encoding for the TNF receptor 1 (TNFR1). 21284532 2012
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 Biomarker disease BEFREE Unlike other autoinflammatory diseases in which anti-TNF therapy is largely a successful treatment option, therapy with the anti-TNF drug infliximab is often ineffective in patients with TRAPS. 19180495 2009
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 Biomarker disease BEFREE The pivotal roles of interleukin (IL)-1beta in cryopyrin-associated periodic syndromes, tumor necrosis factor (TNF) in TNF receptor-associated periodic syndrome, and links to inflammatory cytokine dysregulation in other monogenic autoinflammatory diseases have resulted in effective therapies targeting proinflammatory cytokines IL-1beta and TNF and uncovered other new potential targets for anti-inflammatory therapies. 18606080 2008
CUI: C3267073
Disease: Autoinflammatory disease
Autoinflammatory disease 		0.100 GeneticVariation disease BEFREE Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal dominant systemic autoinflammatory disease associated with heterozygous mutations in TNF receptor 1 (TNFR1). 16684962 2006