TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Disease: Autoinflammatory disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 Biomarker disease BEFREE Increase in the levels of TNF are observed in FMF-KI mice, and many features of FMF overlap with the autoinflammatory disorder associated with TNF receptor signaling. 30457980 2019
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 GeneticVariation disease BEFREE Tumor necrosis factor (TNF)-receptor-associated periodic fever syndrome (TRAPS) is a rare monogenic autoinflammatory disorder characterized by mutations in the <i>TNFRSF1A</i> gene, causing TNF-receptor 1 (TNFR1) misfolding, increased cellular stress, activation of the unfolded protein response (UPR), and hyperresponsiveness to lipopolysaccharide (LPS). 29467762 2018
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 Biomarker disease BEFREE Tumor necrosis factor-associated periodic syndrome is an autoinflammatory disorder classified under hereditary periodic fever syndromes. 28942479 2018
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 GeneticVariation disease BEFREE Mutations in TNFRSF1A encoding TNF receptor 1 (TNFR1) cause the autosomal dominant TNF receptor-associated periodic syndrome (TRAPS): a systemic autoinflammatory disorder. 24668260 2014
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 Biomarker disease BEFREE Steroid- and methotrexate-refractory AOSD cases benefit now from recent insights into autoinflammatory disorders: anakinra seems to be an efficient, well tolerated, steroid-sparing treatment in systemic patterns; tocilizumab seems efficient in AOSD with active arthritis and systemic symptoms while TNFα-blockers could be interesting in chronic polyarticular refractory AOSD. 24657513 2014
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 Biomarker disease BEFREE Tumor necrosis factor (TNF) receptor 1-associated periodic syndrome (TRAPS) is an autoinflammatory disorder caused by autosomal dominantly inherited mutations in the TNF receptor superfamily 1A (TNFRSF1A) gene. 23322460 2013
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 Biomarker disease BEFREE Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal dominant autoinflammatory disorder characterized by periodic fever episodes, arthralgia, myalgia, abdominal pain, serositis, and skin rash. 22884554 2012
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 GeneticVariation disease BEFREE Tumor necrosis factor receptor-1-associated periodic syndrome (TRAPS) is the most common autosomal dominant autoinflammatory disorder and is caused by mutations in the TNFRSF1A gene encoding the 55-kDa receptor for tumor necrosis factor (TNF)-α. TRAPS is characterized by recurrent attacks of fever, typically lasting from 1 to 3 weeks. 20473499 2012
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 Biomarker disease BEFREE This prospective study was undertaken to assess the secretion of IL-1β and 3 IL-1β-induced cytokines (IL-1 receptor antagonist [IL-1Ra], IL-6, and tumor necrosis factor α [TNFα]) in patients' peripheral blood mononuclear cells (PBMCs) cultured ex vivo and to evaluate the patients' response to IL-1Ra (anakinra), a major drug used in the treatment of autoinflammatory disorders. 21480187 2011
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 GeneticVariation disease BEFREE The tumour necrosis factor receptor-1 associated periodic syndrome (TRAPS) is the most common autosomal dominant autoinflammatory disorder and is caused by mutations in the TNFRSF1A gene encoding the 55-kD receptor for tumour necrosis factor-(TNF)-alpha. 20497634 2010
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 Biomarker disease BEFREE Tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autoinflammatory disorder characterized by periodic attacks of fever and inflammation, due to mutations in the gene coding for the TNF type I receptor (TNFRSF1A). 16420550 2006
CUI: C3860213
Disease: Autoinflammatory disorder
Autoinflammatory disorder 		0.100 Biomarker disease BEFREE Tumour necrosis factor (TNF)-receptor-associated periodic syndrome (TRAPS) is a hereditary autoinflammatory disorder involving autosomal-dominant missense mutations in TNF receptor superfamily 1A (TNFRSF1A) ectodomains. 15312137 2004