|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor receptor-1 associated periodic syndrome (TRAPS) is a very rare, hereditary, auto-inflammatory disorder caused by a genetic mutation within the tumor necrosis factor receptor superfamily member one-A (TNFRSF1A) gene, resulting in unregulated, systemic inflammation.
|
30931187 |
2019 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this review, I will discuss the most common autoinflammatory conditions of adulthood including familial Mediterranean fever (FMF), cryopyrin-associated periodic syndrome (CAPS), mevalonate kinase deficiency/hyperimmunoglobulinemia D Syndrome (MKD/HIDS), TNF receptor-associated autoinflammatory syndrome (TRAPS), and systemic juvenile idiopathic arthritis/adult-onset Still's disease (SJIA/AOSD).
|
30394352 |
2019 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS), formerly known as familial Hibernian fever, is the most common autosomal dominant autoinflammatory disease, resulting from mutations in the TNFRSF1A gene, encoding the 55-kD tumor necrosis factor receptor.
|
24935411 |
2014 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF) receptor 1-associated periodic syndrome (TRAPS) is an autoinflammatory disorder caused by autosomal dominantly inherited mutations in the TNF receptor superfamily 1A (TNFRSF1A) gene.
|
23322460 |
2013 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TRAPS is caused by mutations in the gene encoding the TNF Receptor Super Family 1A (TNFRSF1A) on chromosome 12p13.
|
22884554 |
2012 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor receptor-1-associated periodic syndrome (TRAPS) is the most common autosomal dominant autoinflammatory disorder and is caused by mutations in the TNFRSF1A gene encoding the 55-kDa receptor for tumor necrosis factor (TNF)-α. TRAPS is characterized by recurrent attacks of fever, typically lasting from 1 to 3 weeks.
|
20473499 |
2012 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant autoinflammatory condition caused by mutations in the TNFRSF1A gene which encodes the tumor necrosis factor (TNF) receptor, TNFR1.
|
21420073 |
2011 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification of TNFRSF1A mutations as the genetic cause of TRAPS coincided with the wider use of biological agents in medicine and raised the possibility that blocking TNF could potentially represent the primary therapeutic goal in TRAPS, thus disclosing new treatment choices for this complex disease.
|
20943039 |
2010 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnosis of an inherited tumor necrosis factor receptor (TNFR) 1-associated periodic syndrome (TRAPS) was confirmed by genetic analyses.
|
19381634 |
2009 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unlike other autoinflammatory diseases in which anti-TNF therapy is largely a successful treatment option, therapy with the anti-TNF drug infliximab is often ineffective in patients with TRAPS.
|
19180495 |
2009 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor receptor 1-associated periodic syndrome (TRAPS) is an autosomal dominantly inherited autoinflammatory disorder resulting from mutations in the TNFRSF1A gene, which encodes the p55 receptor for tumor necrosis factor alpha.
|
19029521 |
2008 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Falling into TRAPS--receptor misfolding in the TNF receptor 1-associated periodic fever syndrome.
|
17666110 |
2007 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
They include familial Mediterranean fever (FMF); tumor necrosis factor (TNF) receptor periodic syndrome (TRAPS); hyperimmunoglobulinemia D syndrome (HIDS); and hereditary periodic fevers related to mutations in the CIAS1 (cold induced autoinflammatory syndrome 1) gene, such as Muckle-Wells syndrome, familial cold urticaria, and CINCA/NOMID (chronic infantile neurological cutaneous and articular/neonatal-onset multisystemic inflammatory disease).
|
17950649 |
2007 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an inherited autosomal-dominant autoinflammatory condition caused by mutations in the ectodomain of the 55-kd tumor necrosis factor (TNF) receptor superfamily 1A.
|
18050249 |
2007 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TRAPS is caused by mutations in the gene encoding the TNF Receptor Super Family 1A (TNFRSF1A) on chromosome 12p13.
|
16447098 |
2006 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Synthetic anti-TNF agents provide a rational form of therapy for TRAPS, and have been shown to delay or indeed prevent development of systemic amyloidosis (AA type), a life-threatening complication in this condition.
|
16216134 |
2005 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor receptor associated periodic syndrome (TRAPS) is an autosomic-dominant periodic syndrome associated with mutations in the extracellular domain of the 55 kDa TNF receptor.
|
15630744 |
2005 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TRAPS is the first condition for which naturally occurring mutations in a TNF receptor were found; the mutations affect the soluble TNFRSF1A gene in the 12p13 region.
|
15288852 |
2004 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TRAPS is caused by dominant mutations in the 55 kDa TNF receptor gene (TNFRSF1A).
|
11722598 |
2001 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
To characterize both phenotypic (clinical features and magnetic resonance imaging [MRI] findings) and genotypic aspects of autosomal-dominant recurrent fever, also known as tumor necrosis factor receptor (TNFR)-associated periodic syndrome (TRAPS), in a French family and to investigate the role of the mutated 55-kd tumor necrosis factor alpha (TNFalpha) receptor (TNFR1) in the pathogenesis of the disease.
|
10902757 |
2000 |