Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
TNFAIP3 gene encodes A20, an inhibitor of nuclear factor-κB pathway, and is a susceptibility gene for autoimmune diseases.
|
31138864 |
2019 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic variants near the tumor necrosis factor-α-induced protein 3 gene (TNFAIP3) at the chromosomal region 6q23 demonstrated significant associations with multiple autoimmune diseases.
|
29483615 |
2019 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Ablation of A20/Tnfaip3, a critical regulator of NF-κB activation, in DCs leads to constitutive DC activation and development of systemic autoimmunity.
|
31151831 |
2019 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These data showed that autoimmune disease-associated risk variants, TT>A, of the TNFAIP3 locus play a protective role in the pathogenesis of brucellosis.
|
29343543 |
2018 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
A20/Tumor Necrosis Factor α-Induced Protein 3 in Immune Cells Controls Development of Autoinflammation and Autoimmunity: Lessons from Mouse Models.
|
29515565 |
2018 |
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These findings provide insights into enhancers that regulate human A20 expression to prevent inflammatory pathology and autoimmunity.
|
29440643 |
2018 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Our study indicates that TNFAIP3-DEPTOR complex-induced early-onset autophagy is vital for immune inhibition in autoimmune disease.
|
29940800 |
2018 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Previous studies have found that the polymorphisms of tumor necrosis factor-α induced protein 3 (TNFAIP3) were associated with several autoimmune diseases.
|
28448618 |
2017 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor, α-induced protein 3 (TNFAIP3) which encodes a ubiquitin-modifying enzyme (A20), acts as a negative regulator of the NF-κB pathway, and in lymphoma and autoimmune diseases it is frequently inactivated by mutations and/or deletions.
|
26986245 |
2016 |
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Loss of TNFAIP3 mRNA and its encoded protein, A20, impaired tumor necrosis factor-α-induced receptor-mediated downregulation of nuclear factor-κB signaling, a hallmark of autoimmunity.
|
26821284 |
2016 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The polymorphisms of tumour necrosis factor alpha-induced protein 3 (TNFAIP3) have been found to associate with several autoimmune diseases.
|
26846592 |
2016 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility.
|
26092158 |
2015 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Variations in two genes of the tumour necrosis factor (TNF) alpha pathway have been implicated in the pathogenesis of autoimmune diseases: polymorphisms in the TNFRSF1A gene, encoding TNF receptor 1, showed significant association with MS in genomewide association scans, and variation in or near the TNFAIP3 gene, coding for a negative regulator of NFkB, was associated with MS, systemic lupus erythematosus, diabetes and rheumatoid arthritis.
|
25684197 |
2015 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
A20-deficient mast cells exacerbate inflammatory responses in vivo.
|
24453940 |
2014 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases.
|
25302371 |
2014 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Single-nucleotide polymorphisms (SNPs) in the TNFSF4, TNFAIP3 and FAM167A-BLK genes have been associated with several autoimmune diseases.
|
23635951 |
2013 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Genetic studies have shown an association between multiple autoimmune diseases and TNFAIP3 (A20) and TNIP1 (ABIN1), both repressors of NF-κB and of IKBKE (IKKε), which is an NF-κB activator.
|
23944604 |
2013 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Polymorphisms of TNFAIP3, which encodes the A20 protein that plays a key role in controlling nuclear factor κB activation, have been associated with several autoimmune diseases.
|
24159176 |
2013 |
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
TNFAIP3 gene may have a key role in autoimmunity through its action as a negative regulator of the NF-κB pathway.
|
21833526 |
2012 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice.
|
21088135 |
2011 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases.
|
21326317 |
2011 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.
|
21787353 |
2011 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Because genetic polymorphisms in TNFAIP3 are associated with human autoimmune disorders, these findings identify A20-mediated control of DC activation as a crucial checkpoint in the development of systemic autoimmunity.
|
21723156 |
2011 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
For example, a number of autoimmune diseases have been associated with variants in the PTPN22, TNFAIP3 and CTLA4 genes.
|
20854658 |
2010 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Convincing associations between TNFAIP3 variants and autoimmune diseases have been reported.
|
20511617 |
2010 |