|
Dermatitis, Atopic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fn14 deficiency also attenuates the up-regulation of TNFR1 in skin lesions of atopic dermatitis.
|
31515807 |
2020 |
|
Eczema
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fn14 deficiency also attenuates the up-regulation of TNFR1 in skin lesions of atopic dermatitis.
|
31515807 |
2020 |
|
polyps
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that Polyp-Au-GO composite inhibits VSMC proliferation and TNF-R-mediated inflammatory responses.
|
31837585 |
2020 |
|
Back Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Human IVD cells from the nucleus pulposus of patients receiving surgery for back pain were obtained and the regulation of TNFR1/IL1R1 signaling by a lentiviral CRISPR epigenome editing system was tested.
|
31140325 |
2019 |
|
Bacterial Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We can conclude that targeting of TNFR1 and IL-1R (with major focus on surface expression study) either through blockage of intracellular receptor trafficking pathway or via surface receptor shedding diminishes TNFR1/IL-1R interaction and consequently downregulates CXCR1 expression along with inflammatory signalling pathways during bacterial infections.
|
31290001 |
2019 |
|
Hydrocephalus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We sought to compare TNF-R1 levels in peripheral venous blood and arterial blood closer to the ruptured aneurysm to study the association of TNF-R1 blood levels with poor prognosis (modified Rankin Scale > 2 at discharge, 3 and 6 months) and complications (hydrocephalus or delayed cerebral ischemia/DCI) following SAH.
|
30673997 |
2019 |
|
Hypertension, Renovascular
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In rats with renovascular hypertension, AP neurons that expressed TNF-α type-1 receptor (TNFR1) remained constantly activated (expressed c-Fos) and injection of TNFR1 neutralizing antibody into the AP returned BP (systolic: ∼151 mmHg) to normotensive levels (systolic: ∼108 mmHg).
|
30358805 |
2019 |
|
Lupus Nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Soluble TNF-R1, VEGF and other cytokines as markers of disease activity in systemic lupus erythematosus and lupus nephritis.
|
31046570 |
2019 |
|
Retinopathy of Prematurity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Conversely, CpG methylation at three probes within tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and in two alternative probes within the BDNF and ANGPT1 genes was associated with an increased risk of ROP.
|
31266060 |
2019 |
|
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus blockade of both TNFR1-dependent and TNFR1-independent cell death might be an alternative strategy to treat skin diseases when treatment with anti-TNF-α antibody alone is not sufficient.
|
29596938 |
2019 |
|
Aneurysm, Ruptured
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We sought to compare TNF-R1 levels in peripheral venous blood and arterial blood closer to the ruptured aneurysm to study the association of TNF-R1 blood levels with poor prognosis (modified Rankin Scale > 2 at discharge, 3 and 6 months) and complications (hydrocephalus or delayed cerebral ischemia/DCI) following SAH.
|
30673997 |
2019 |
|
Mental deterioration
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Elevated levels of TNFR1 were also associated with steeper rate of cognitive decline on follow-up but not with baseline cognitive performance.
|
31555121 |
2019 |
|
Hemophilic arthropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of TNF-α, TNF-R1, and TNF-R2 was strongly increased in HA synovium (n = 10) compared to the non-inflamed osteoarthritis control synovium (n = 8), as assessed by both immunohistochemistry and Western blotting.
|
31261789 |
2019 |
|
Malignant Bone Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of IL-1R, IL-6R, and TNFR1 alleviated mechanical and thermal hyperalgesia in bone cancer rats, accompanied with downregulated PI3K-mTOR.
|
30717619 |
2019 |
|
Squamous intraepithelial lesion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
SIL patients (<i>n</i> = 179) and healthy volunteers (<i>n</i> = 227) were enrolled for TNFR1 genotyping analysis by PCR-RFLP in blood samples and TNFR1 protein expression in cervical tissue by immunohistochemistry.
|
30847024 |
2019 |
|
Nodular lymphoid hyperplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of TNFR1 prevents the development of both types of follicles, but deficiency of TNFR1 in the hematopoietic compartment only prevents the iBALT and not the NLH phenotype.
|
30107066 |
2019 |
|
Hereditary hemochromatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
At p60, TPR was lower than baseline for HH conditions (<i>p</i> < 0.05), whereas after exercise in NN, and NNsubmax conditions, TPR recovered to baseline by p60.
|
31178742 |
2019 |
|
Hepatic granuloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we investigated the role of myeloid and T cell specific TNFR1 and R2 expression, and show that absence of TNFR1 in myeloid cells attenuated liver granuloma formation and liver injury in response to acute BCG infection, while TNFR2 expressed in myeloid cells contributed only to liver injury.
|
30923339 |
2019 |
|
BCG infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, TNFR1 expressed by myeloid cells plays a critical role in mononuclear cell recruitment and injury of the liver after BCG infection.
|
30923339 |
2019 |
|
Macrophage Activation Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum cytokine levels (neopterin, IL-18, and CXCL9 and soluble tumor necrosis factor receptor type I (sTNFR-I) and II) were determined by enzyme-linked immunosorbent assay in 78 patients with s-JIA, including 21 with MAS.
|
31449879 |
2019 |
|
Mild cognitive disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Higher levels of plasma TNFR1 were associated with greater risk of progression from normal cognition to MCI (HR: 3.27; 95% confidence interval, CI: 1.27, 8.40).
|
31555121 |
2019 |
|
Precursor B-cell lymphoblastic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
This subset was defined by a characteristic gene expression signature with 127 differentially regulated genes, amongst them TNFRSF1A encoding TNFR1, and a critical role of TNFR1 in SM-induced cell death in sensitive BCP-ALL was confirmed on the functional level.
|
31749151 |
2019 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of death receptor systems TRAIL-R1/-R2/-R4, CD95 and TNF-R1 and their cognate ligands in pancreatic ductal adenocarcinoma.
|
30375637 |
2019 |
|
Septic peritonitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that cell-specific targeting of TNFR1 to these cell types has no therapeutic future in septic peritonitis.
|
31787972 |
2019 |
|
Autoimmune Lymphoproliferative Syndrome Type 2B
|
0.010 |
Biomarker
|
disease |
BEFREE |
FADD deficiency sensitized more efficiently for TNFR1-mediated necroptosis than caspase-8 deficiency pointing to a caspase-8 independent inhibitory activity of FADD on TNF-induced necroptosis.
|
30741924 |
2019 |