TNFRSF1A, TNF receptor superfamily member 1A, 7132

N. diseases: 487; N. variants: 48
Disease: Cachexia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006625
Disease: Cachexia
Cachexia 		0.520 AlteredExpression phenotype BEFREE We show that in skeletal muscle of cachectic patients there is 1) increased expression and activity of the TNF-alpha signaling, including TNF-alpha mRNA, activation of TNFR1, and TNF-alpha-associated to TNFR1; 2) increased oxidative stress, as determined by the presence of malondialdehyde-lysine adducts; 3) increased NOS2 mRNA and protein; 4) decreased expression of Jun-D, myogenin, myosin, and CKM mRNA and protein; 5) impaired CKM-E box binding activities, associated with decreased Jun-D/myogenin activities; and 6) oxidative modification and ubiquitination of Jun-D. 19470832 2009
CUI: C0006625
Disease: Cachexia
Cachexia 		0.520 Therapeutic phenotype CTD_human Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia. 18801959 2008
CUI: C0006625
Disease: Cachexia
Cachexia 		0.520 Biomarker phenotype RGD The mRNA content of both TNF-alpha and its receptors (TNFR1 and TNFR2) in skeletal muscle and adipose tissue from cachectic rats has been assessed. 16077938 2005
CUI: C0006625
Disease: Cachexia
Cachexia 		0.520 Biomarker phenotype BEFREE Mice deficient in TTP and TNFR1, or in TTP and both receptors, were protected from developing the TNF-alpha-induced cachexia and inflammation. 11588035 2001