Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.590 Biomarker disease BEFREE Moreover, higher TNFR-1 and TNFR-2 was also significantly associated with CVD events and mortality in patients with type 2 diabetes. 31813103 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.590 Biomarker disease BEFREE Independent associations exist between high plasma TNFR1 or IMA concentrations and increased 5.6-year risk of major LEAD in people with type 2 diabetes. 30072406 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.590 Biomarker disease BEFREE LADA versus classic adult-onset type 1 diabetes was independently related to sTNFRII (odds ratio [OR] 1.9 [95% CI 1.01-3.97]; <i>P</i> = 0.047) and hs-CRP levels (OR 0.78 [95% CI 0.62-0.96]; <i>P</i> = 0.019), and a higher number of total leukocytes lowered the risk of LADA compared with type 2 diabetes (OR 0.98 [95% CI 0.97-0.99]; <i>P</i> = 0.036). 29358494 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.590 Biomarker disease BEFREE Our study confirms plasma TNFR1 as a surrogate of renal structural and functional impairment in patients with type 2 diabetes mellitus. 29122448 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.590 Biomarker disease BEFREE The involvement of tumor necrosis factor (TNF)-related biomarkers [TNFα, progranulin (PGRN), TNF receptors (TNFR1 and TNFR2)] and uric acid (UA) in renal function decline was investigated in patients with type 2 diabetes (T2D). 30333553 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.590 Biomarker disease BEFREE This study suggests that the risk factors associated with the minor vs. major amputation including biomarkers such as TNFR1 should be considered differently in patients with T2D. 29879997 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.590 Biomarker disease BEFREE Compared with traditional serum markers, TNFR1 and TNFR2 are associated with heart failure risk in type 2 diabetes mellitus patients. 28367848 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.590 Biomarker disease RGD These results demonstrate the endothelial dysfunction occurring in type 2 diabetes is the result of effects of the inflammatory cytokine TNF that activates NAD(P)H oxidase and xanthine oxidase; and perhaps acts mainly through the overexpression of TNFR1. 20559450 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.590 Biomarker disease BEFREE Lower rate of tumor necrosis factor-alpha -863A allele and higher concentration of tumor necrosis factor-alpha receptor 2 in first-degree relatives of subjects with type 2 diabetes. 12898475 2003
Diabetes Mellitus, Non-Insulin-Dependent
0.590 Biomarker disease CTD_human Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus. 11882518 2002
Diabetes Mellitus, Non-Insulin-Dependent
0.590 Biomarker disease LHGDN Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus. 11882518 2002