|
Lichen Planus, Oral
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicate TN-C may have a key role in promoting T cell migration at the epithelial-mesenchymal junction in OLP.
|
31783297 |
2020 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
TN-C is increased in the synovial fluid in patients with OA and RA.
|
28722504 |
2018 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The results demonstrate that a point mutation in a single constituent of myofilaments (slow/cardiac troponin C) led to major changes in physiological properties of skeletal muscle and converted slow muscle toward a fast muscle phenotype with reduced fatigue resistance and Ca<sup>2+</sup> sensitivity of force generation.
|
29992562 |
2018 |
|
Arthropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
TN-C could be a useful biochemical marker for joint disease.
|
28722504 |
2018 |
|
Lymphatic Metastasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings indicated that MFAP5 and TNNC1 may be potential markers for predicting occult cervical lymphatic metastasis and prognosis of oral tongue carcinoma.
|
27713166 |
2017 |
|
Malignant neoplasm of tongue
|
0.010 |
Biomarker
|
disease |
BEFREE |
MFAP5 and TNNC1: Potential markers for predicting occult cervical lymphatic metastasis and prognosis in early stage tongue cancer.
|
27713166 |
2017 |
|
Tongue Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings indicated that MFAP5 and TNNC1 may be potential markers for predicting occult cervical lymphatic metastasis and prognosis of oral tongue carcinoma.
|
27713166 |
2017 |
|
Septal hypertrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We describe a pediatric proband with fatal restrictive cardiomyopathy associated with septal hypertrophy and compound heterozygosity for TNNC1 mutations (NM_003280: p.A8V [c.C23T] and p.D145E [c.C435A]).
|
27604170 |
2016 |
|
Cardiomyopathy, Hypertrophic, Familial
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q.
|
26341255 |
2015 |
|
Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
mTOR signal transduction pathways contribute to TN-C FNIII A1 overexpression by mechanical stress in osteosarcoma cells.
|
24598996 |
2014 |
|
Osteosarcoma of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
mTOR signal transduction pathways contribute to TN-C FNIII A1 overexpression by mechanical stress in osteosarcoma cells.
|
24598996 |
2014 |
|
Childhood Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
mTOR signal transduction pathways contribute to TN-C FNIII A1 overexpression by mechanical stress in osteosarcoma cells.
|
24598996 |
2014 |
|
Pulmonary Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TN-C levels were quantified in sera from normal donors and patients with SSc with or without pulmonary fibrosis, using an enzyme-linked immunosorbent assay.
|
21898349 |
2012 |
|
Nasal Polyps
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tn-C protein expression was significantly up-regulated in NP tissues and correlated with TGF-beta1+ eosinophils.
|
17181107 |
2007 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TN-C was increased in all invasive tumours and metastases, especially at invasion fronts, but not in benign nevi or non-invasive melanomas.
|
16924594 |
2006 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
TN-C was increased in all invasive tumours and metastases, especially at invasion fronts, but not in benign nevi or non-invasive melanomas.
|
16924594 |
2006 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
TN-C was increased in all invasive tumours and metastases, especially at invasion fronts, but not in benign nevi or non-invasive melanomas.
|
16924594 |
2006 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
TN-C expression is especially high at sites of epithelial mesenchymal transition (EMT), which are found frequently at the invasion front of well-differentiated human colorectal adenocarcinomas.
|
16091738 |
2005 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TN-C expression was studied in tumor and non-tumor tissue of patients with NSCLC at the mRNA and protein level.
|
15603851 |
2005 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
TN-C expression is especially high at sites of epithelial mesenchymal transition (EMT), which are found frequently at the invasion front of well-differentiated human colorectal adenocarcinomas.
|
16091738 |
2005 |
|
Heart Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We also present recent structural work that have identified the docking sites of several cardiotonic drugs on cardiac troponin C and discuss their relevance in the direction of troponin based drug design in the therapy of heart disease.
|
15711886 |
2004 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tenascin (TN)-C and fibronectin (FN), which are glycoproteins of the extracellular matrix (ECM), are up-regulated in cancer tissues, including breast cancer.
|
9306963 |
1997 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tenascin (TN)-C and fibronectin (FN), which are glycoproteins of the extracellular matrix (ECM), are up-regulated in cancer tissues, including breast cancer.
|
9306963 |
1997 |
|
Dentinogenesis Imperfecta
|
0.010 |
Biomarker
|
disease |
BEFREE |
TN-C reactivity was present in the dentin matrix of all teeth obtained from two patients with different OI phenotypes and DI, and in one out of three teeth from one patient who also had DI.
|
8655763 |
1996 |
|
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Levosimendan is a calcium sensitizer that promotes myocyte contractility through its calcium-dependent interaction with cardiac troponin C. Administered intravenously, it has been used for nearly 2 decades to treat acute and advanced heart failure and to support the heart function in various therapy settings characterized by low cardiac output.
|
31730560 |
2019 |