TNNI3, troponin I3, cardiac type, 7137

N. diseases: 159; N. variants: 50
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Advancements in health care monitoring demand a rapid, accurate and reliable early diagnosis of "Heart Attack" (acute myocardial infarction) with an objective to develop a cost-effective, rapid and label-free point of care diagnostic test kit for the detection of cardiac troponin I (cTnI) on paper-based multi-frequency impedimetric transducers. 31844990 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE A novel high-sensitivity cardiac troponin I assay can safely identify patients at low risk of myocardial infarction or cardiac death. 30442743 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE This work demonstrates the application of the LRSPP biosensors for the detection of human cardiac troponin I (cTnI) protein. cTnI is a biological marker for acute myocardial infarction (AMI), often referred to as a heart attack, which can be diagnosed by elevated levels of cTnI in patient blood. 30717341 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Six-hour cardiac troponin I (cTnI) was measured with a primary end point of PMI defined as rise ≫×5 upper limit of normal (280 ng/L). 31277053 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE The aim of this study was to evaluate the impact of implementing a high-sensitivity cardiac troponin I assay with sex-specific diagnostic thresholds for myocardial infarction in women and men with suspected acute coronary syndrome. 31623760 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Clinical Use of a New High-Sensitivity Cardiac Troponin I Assay in Patients with Suspected Myocardial Infarction. 31570633 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 AlteredExpression disease BEFREE Exogenous NADPH (8-16 mg/kg) significantly decreased myocardial infarct size and reduced serum levels of lactate dehydrogenase (LDH) and cardiac troponin I (cTn-I). 31776448 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE A nanozyme-linked immunosorbent assay is described for cardiac troponin I which is a biomarker for myocardial infarction. 30989395 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE On the basis of this fascinating sensing platform, a robust label-free ECL immunosensor was constructed for ultrasensitive detection of cTnI, the main marker of myocardial infarction, with good stability and a detection limit as low as 0.58 fg mL<sup>-1</sup> (S/N = 3). 30680992 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE Our aim was to evaluate the diagnostic ability of absolute and relative conventional cardiac troponin I (cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) in the distinction between type 1 and type 2 MI in patients presenting at the emergency department with non-ST-segment elevation acute chest pain within the first 12 h. 29303766 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Rapidity and high sensitivity are the critical factors for the diagnoses of heart attacks and cardiac troponin I (cTnI) is used as a gold standard marker for its diagnosis. 29935487 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE On the basis of the simple sandwich immunoreaction approach, cardiac troponin-I antigen (cTnI), a kind of biomarker related with myocardial infarction, was chosen as a detection model using an IRMOF-3-enriched CdTe labeled antibody as the signal probe. 29457712 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Cardioprotective potential of CuNP (1mg/kg/day, po, 4 weeks) and exercise (swimming, 90min, 5days/4 weeks) either alone or in combination was estimated by measuring the surge in serum nitrite/nitrate concentration and reduction in creatine kinase MB (CKMB), lactate dehydrogenase (LDH), cardiac troponin I (cTnI), lipid profile, oxidative stress, structural abnormalities against isproterenol (ISO)-induced MI. 29957339 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Prospective studies measuring high-sensitivity cardiac troponin I concentrations in patients with suspected acute coronary syndrome in which the diagnosis was adjudicated according to the universal definition of myocardial infarction. 29127948 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE In contrast, enhanced NMDAR activity under I/R conditions produced significant increases in [Ca]i levels (∼1.2% increase), significant losses in left ventricular function (∼5.4% decrease), significant multi-fold increases in creatine kinase, creatine kinase isoenzyme MB, lactate dehydrogenase, cardiac troponin I, and cardiac troponin T, significant increases in generalized myocardial necrosis (∼36% increase) and apoptosis (∼150% increase), and significant multi-fold increases in PKC-δ, PKC-ε, Akt, and extracellular signal-regulated kinase phosphorylation (all P < 0.05). 28777252 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Ultrasensitive cardiac troponin I antibody based nanohybrid sensor for rapid detection of human heart attack. 27865959 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Human cardiac troponin-I (cTnI) is one of the most sensitive and specific indicators, used in the diagnosis of myocardial infarction. 27070210 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Type 1 and 2 Myocardial Infarction and Myocardial Injury: Clinical Transition to High-Sensitivity Cardiac Troponin I. 28739197 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE <b>Objective</b> To evaluate how selection of patients for high sensitivity cardiac troponin testing affects the diagnosis of myocardial infarction across different healthcare settings.<b>Design</b> Prospective study of three independent consecutive patient populations presenting to emergency departments.<b>Setting</b> Secondary and tertiary care hospitals in the United Kingdom and United States.<b>Participants</b> High sensitivity cardiac troponin I concentrations were measured in 8500 consecutive patients presenting to emergency departments: unselected patients in the UK (n=1054) and two selected populations of patients in whom troponin testing was requested by the attending clinician in the UK (n=5815) and the US (n=1631). 29114078 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Copeptin is a marker of endogenous stress including early myocardial infarction(MI) and has value in early rule out of MI when used with cardiac troponin I(cTnI). 27847253 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 AlteredExpression disease BEFREE The nRIC group repeatedly underwent 5 min of ischemia and 5 min of reperfusion in the left hind limb for three cycles every other day until weeks 4, 6, and 8 after MI. nRIC improved cardiac hemodynamic function and mitochondrial respiratory function through increasing myocardial levels of mitochondrial respiratory chain complexes I, II, III, IV, and adenosine triphosphate (ATP) and decreasing the activity of nitric oxide synthase (NOS). nRIC could inhibit cardiomyocytes apoptosis and reduce myocardium injury through raising the expression of Bcl-2 and reduced the content of creatine kinase-MB, cardiac troponin I and Bax. 28479248 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Among the 249 adjudicated MIs using the contemporary cTnI, only 69 (28%) were ICD-coded MIs. 27811209 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Intracoronary Bb increased immediately after AXCL, and the levels were directly correlated with peripheral blood levels of cardiac troponin I, an established biomarker of myocardial necrosis (Spearman coefficient = 0.465, P < 0.01). 28662037 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Algorithms incorporating cardiac troponin and glucose for early rule-in/rule-out were the most cost effective and clinically safest methods (i.e., ≤1 MI missed) for early decision making, with hs-cTnI and glucose yielding lower costs compared to cTnI and glucose, despite the higher price for the hs-cTnI test. 27811206 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Additionally, immunohistochemistry revealed that HSV-tk-labelled BMSCs-derived cells were positive for cardiac troponin I. Multimodal imaging systems combining an α-MHC-HSV1-tk/<sup>18</sup>F-FHBG reporter gene and <sup>18</sup>F-FDG metabolism imaging could be used to track differentiation of transplanted BMSCs and recovery of cardiac function in MI. 28740146 2017