TNNI3, troponin I3, cardiac type, 7137

N. diseases: 159; N. variants: 50
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Acute myocardial infarction (AMI) is characterized by chest pain as well as cardiac troponin I (cTnI) and electrocardiography (ECG) changes. 31624755 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Early detection of cardiac troponin I (cTnI), B-type natriuretic peptide (BNP), and myoglobin (Myo) is essential for the diagnosis of acute myocardial infarction (AMI) and heart failure (HF). 30985109 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE It was significantly available for microRNA-1 to early diagnose AMI with an optimal cutoff value of 2.215 and diagnostic accuracy could be improved when combined with cardiac troponin I. 30611212 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) are important diagnostic biomarkers for acute myocardial infarction (AMI). 31553332 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 AlteredExpression disease BEFREE We found that plasma levels of miR-22-5p and miR-150-3p were significantly higher during the early stage of AMI and their expression levels peaked earlier than cTnI. 31179325 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Rapid rule out of acute myocardial infarction in the observe zone using a combination of presentation N-terminal pro-B-type natriuretic peptide and high-sensitivity cardiac troponin I. 31173734 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Measurement of cardiac troponin I in the blood is crucial for the early diagnosis of acute myocardial infarction. 31571481 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 AlteredExpression disease BEFREE Furthermore, the commendable sensing performance of our proposed ELISA in the determination of the cTnI level in diluted human serum unambiguously illustrates great potential in the early diagnosis of acute myocardial infarction. 31124658 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE This work demonstrates the application of the LRSPP biosensors for the detection of human cardiac troponin I (cTnI) protein. cTnI is a biological marker for acute myocardial infarction (AMI), often referred to as a heart attack, which can be diagnosed by elevated levels of cTnI in patient blood. 30717341 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Because of their cardiac specificity, cardiac troponin I or T are the recommended biomarkers for diagnosing acute myocardial infarction. 30797799 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Due to its myocardial specificity, cTnI is widely used for the diagnosis of AMI diseases. 30471567 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Advancements in health care monitoring demand a rapid, accurate and reliable early diagnosis of "Heart Attack" (acute myocardial infarction) with an objective to develop a cost-effective, rapid and label-free point of care diagnostic test kit for the detection of cardiac troponin I (cTnI) on paper-based multi-frequency impedimetric transducers. 31844990 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Cardiac troponin I (cTnI) was considered as the "gold standard" for acute myocardial infarction (AMI) diagnosis owing to its superior cardiac specificity for cardiac damage and showing little or no changes in patients with a skeletal muscle disease or trauma. 30666995 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Two-Hour Algorithm for Rapid Triage of Suspected Acute Myocardial Infarction Using a High-Sensitivity Cardiac Troponin I Assay. 31570634 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE In this study, in order to rapidly detect AMI disease, the authors fabricated a label-free electrochemical biosensor composed of a multi-functional DNA structure on Au nanospike (AuNS) with a fabricated Au micro-gap electrode which was incorporated with a PCB chip in order to detect cardiac troponin I (cTnI). 30554012 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE In this work, we developed an electrochemical biosensor by using magnetic metal organic framework (MMOF) nanocatalysts and DNA nanotetrahedron (NTH) based dual-aptamer probes for nonenzymatic detection of cardiac troponin I (cTnI), a gold standard biomarker for the early diagnosis of AMI. 30954926 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE In this study, an enzyme linked DNA aptamer based assay was optimized for human cardiac troponin I (cTnI) detection which is a prominent biomarker for acute myocardial infarction (AMI), on an integrated microfluidic platform. 31317135 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE The AMI diagnostic efficacy of miR-1 and cTnI were similar (P > 0.05). 31611081 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Therefore, we construct a sandwich-type electrochemical immunosensor using TB-2HP5@Au-Pd/MnO<sub>2</sub> nanocomposites as the transducing materials for robust and ultrasensitive detection of cardiac troponin I (cTnI), a significant biomarker of acute myocardial infarction. 30745283 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE The interaction of cTnI with fGQDs for the early diagnosis of acute myocardial infarction was investigated using cyclic voltammetry (CV) and amperometry. 31758063 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE Human cardiac troponin I (cTnI) has been regarded as a golden biomarker for AMI due to its excellent selectivity. 29725733 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE A reliable lateral flow immunoassay (LFIA) based on a facile one-step synthesis of single microspheres in combining with immunochromatography technique was developed to establish a new point-of-care test (POCT) for the rapid and early detection of cardiac troponin I (cTnI), a kind of cardiac specific biomarker for acute myocardial infarction (AMI). 29735888 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 AlteredExpression disease BEFREE A multivariate regression model showed as predictors for AMI the variables ECG data by admittance at the emergency room, previous AMI history, levels of both Mgb at the third hour, and cTnI at the sixth hour after admission. 29607545 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE We aimed to evaluate the diagnostic performance of combinations of high-sensitivity (hs) cTnI and hs-cTnT for the early diagnosis of acute myocardial infarction. 29691270 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.100 Biomarker disease BEFREE This biomedical sensor can be used in hospitals and homes alike, for early detection of cTnI which is a clinical marker for acute myocardial infarction. 29376635 2018