Nonnuclear polymorphic congenital cataract
|
0.010 |
Biomarker
|
disease |
BEFREE |
Evidence for linkage was found for chromosome 2q33-35 with PCC mapping near D2S72 and TNP1.
|
8733140 |
1996 |
Adrenal Gland Pheochromocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Evidence for linkage was found for chromosome 2q33-35 with PCC mapping near D2S72 and TNP1.
|
8733140 |
1996 |
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since all of these functions are of potential importance in the induction or maintenance or both of autoimmune disease, samples from the Arthritis and Rheumatism Council's repository of multicase rheumatoid arthritis families were typed for a dinucleotide repeat in the NRAMP1 promoter region and four other 2q34 (TNP1) or 2q35 (IL8R, VIL1, DES) marker genes.
|
8863160 |
1996 |
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Since all of these functions are of potential importance in the induction or maintenance or both of autoimmune disease, samples from the Arthritis and Rheumatism Council's repository of multicase rheumatoid arthritis families were typed for a dinucleotide repeat in the NRAMP1 promoter region and four other 2q34 (TNP1) or 2q35 (IL8R, VIL1, DES) marker genes.
|
8863160 |
1996 |
Collagen Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Since all of these functions are of potential importance in the induction or maintenance or both of autoimmune disease, samples from the Arthritis and Rheumatism Council's repository of multicase rheumatoid arthritis families were typed for a dinucleotide repeat in the NRAMP1 promoter region and four other 2q34 (TNP1) or 2q35 (IL8R, VIL1, DES) marker genes.
|
8863160 |
1996 |
Rheumatism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since all of these functions are of potential importance in the induction or maintenance or both of autoimmune disease, samples from the Arthritis and Rheumatism Council's repository of multicase rheumatoid arthritis families were typed for a dinucleotide repeat in the NRAMP1 promoter region and four other 2q34 (TNP1) or 2q35 (IL8R, VIL1, DES) marker genes.
|
8863160 |
1996 |
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
RT-PCR analyses revealed that hTR and TP I mRNA were constitutively expressed both in tumor and in normal tissues.
|
9808519 |
1998 |
Azoospermia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Haplotype association analysis showed a significant omnibus association (omnibus χ(2) = 7.87, p = 0.0195) for the single nucleotide polymorphisms (SNPs) in the TNP1 gene with azoospermia.
|
20522125 |
2011 |
Malignant neoplasm of breast
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2).
|
23593120 |
2013 |
Breast Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2).
|
23593120 |
2013 |
Male infertility
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
At a false discovery rate (FDR) of 5%, we identified one significant whole blood DNA methylation change linked to conception via IVF, which was located ~3 kb upstream of TNP1, a gene previously linked to male infertility.
|
28340599 |
2017 |
Male infertility
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
To investigate the role of <i>PRM1/2</i> and transition protein 1 (<i>TNP1</i>) polymorphisms in male infertility, 636 infertile men and 442 healthy individuals were recruited into this case-controlled study of the Chinese Han population, using MassARRAY technology to analyze genotypes.
|
28977892 |
2017 |
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Inhibition of autophagy with 3-methyl adenine or chloroquine has a remarkable synergistic effect on TNP-1-mediated PTT in triple-negative (4T1), drug-resistant (MCF7/MDR) and patient-derived breast cancer models, achieving a level of efficacy unattainable with TNP-2, the identically-shaped CuPd nanoparticles that have a higher photothermal conversion efficiency but no autophagy-inducing activity.
|
30315154 |
2018 |
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Inhibition of autophagy with 3-methyl adenine or chloroquine has a remarkable synergistic effect on TNP-1-mediated PTT in triple-negative (4T1), drug-resistant (MCF7/MDR) and patient-derived breast cancer models, achieving a level of efficacy unattainable with TNP-2, the identically-shaped CuPd nanoparticles that have a higher photothermal conversion efficiency but no autophagy-inducing activity.
|
30315154 |
2018 |
Azoospermia
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study applied cfs-mRNA of ESX1, ZMYND15 and its target haploid genes (TNP1 and PRM1) to identify the presence of spermatozoa in men with azoospermia.
|
31793700 |
2020 |