(Idiopathic) normal pressure hydrocephalus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CSF concentrations of brevican, neurocan and tenascin-R (only in time point 3) after TBI were lower than in the idiopathic normal pressure hydrocephalus group (p < 0.0001, p < 0.0001, and p = 0.0008, respectively).
|
30980710 |
2019 |
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
CSF tenascin-C and tenascin-R concentrations were significantly higher in women than in men in the AD group (p = 0.02).
|
31156172 |
2019 |
Astrocytosis
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
The parallel development of increase in focal granular TN-R immunoreactivity, reactive mossy fiber sprouting and astrogliosis in CA3 implies a role for TN-R in axon targeting and synapse formation and/or in astrocytic targeting and interactions with the ECM during lesion-induced sprouting in the adult brain.
|
15120744 |
2004 |
Attention deficit hyperactivity disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We observed a genome-wide significant association (p = 3.15E-08) between ADHD and rs6686722, mapped to the Tenascin R (TNR) gene.
|
30563984 |
2018 |
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found no evidence to support the notion that CAG/CTG TNR genes are major determinants of phenotypic severity or age at onset in the population examined, and conclude that for most cases of bipolar disorder TNR genes may operate as susceptibility genes rather than as single genes of major effect.
|
9359972 |
1997 |
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we studied a quadruple knock-out mouse (Q4) that lacks four ECM components: brevican, neurocan, tenascin-C and tenascin-R. We applied functional connectivity optical intrinsic signal (fcOIS) imaging in Q4 mice and wild-type (129S1 mice) before and 14 days after photothrombotic stroke (PT) to understand how the lack of crucial ECM components affects neuronal networks and functional recovery after stroke.
|
29367009 |
2018 |
Childhood Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate the role of TNR/11q#1 variants as risk-modifying factors in leukemogenesis, we conducted a case-control study on 113 acute lymphotic leukemia (ALL) patients, 82 CLL patients and 146 healthy controls of Russian origin.
|
15225161 |
2004 |
Chronic leukemia (category)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TNR/11q#1 trinucleotide (GCC)n repeat alleles and predisposition to acute and chronic leukemia.
|
15225161 |
2004 |
Chronic Lymphocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of certain alleles and genotypes of the TNR/11q#1 repeat with both acute and chronic lymphocytic leukemia suggests the presence of a cancer related gene, involved in a wide spectrum of neoplasia, in the vicinity of this repeat.
|
15225161 |
2004 |
Congenital Abnormality
|
0.010 |
AlteredExpression
|
group |
BEFREE |
TN-R's expression pattern suggests a possible primary or secondary role in certain neurological problems including malformations, tumors and neurodegenerative disorders.
|
22634605 |
2012 |
Deuteranomaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Results indicate that GCLC TNR genotype 7/7 is negatively associated with CBD (odds ratio [OR] = 0.28, 95% confidence interval [CI] = 0.08-0.95) and the GCLM-588 C/C SNP genotype is associated with CBD susceptibility (OR = 3.07, 95% CI = 1.00-9.37).
|
16766924 |
2006 |
Early Pregnancy Loss
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Exudative age-related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analysis of disease progression in age-related macular degeneration.
|
29346644 |
2018 |
exudative macular degeneration
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analysis of disease progression in age-related macular degeneration.
|
29346644 |
2018 |
Fuchs Endothelial Dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine if CTG18.1 TNR expansion length prognosticates the clinical progression of Fuchs' Endothelial Corneal Dystrophy (FECD).
|
30682148 |
2019 |
Ganglioglioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gangliogliomas strongly expressed tenascin-R too.
|
20202125 |
2010 |
Geographic Atrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we detected association of rs58978565 near TNR (P = 2.3 × 10-8), rs28368872 near ATF7IP2 (P = 2.9 × 10-8) and rs142450006 near MMP9 (P = 0.0006) with progression to choroidal neovascularization but not geographic atrophy.
|
29346644 |
2018 |
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We have clearly confirmed the overexpression of tenascin-R in pilocytic astrocytomas vs. glioblastomas at mRNA and protein levels.
|
20202125 |
2010 |
Gliosis
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
The parallel development of increase in focal granular TN-R immunoreactivity, reactive mossy fiber sprouting and astrogliosis in CA3 implies a role for TN-R in axon targeting and synapse formation and/or in astrocytic targeting and interactions with the ECM during lesion-induced sprouting in the adult brain.
|
15120744 |
2004 |
Intellectual Disability
|
0.010 |
Biomarker
|
group |
BEFREE |
This is the first report of a complete loss of TNR associated with intellectual disability.
|
22730557 |
2012 |
leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate the role of TNR/11q#1 variants as risk-modifying factors in leukemogenesis, we conducted a case-control study on 113 acute lymphotic leukemia (ALL) patients, 82 CLL patients and 146 healthy controls of Russian origin.
|
15225161 |
2004 |
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
Leukemogenesis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate the role of TNR/11q#1 variants as risk-modifying factors in leukemogenesis, we conducted a case-control study on 113 acute lymphotic leukemia (ALL) patients, 82 CLL patients and 146 healthy controls of Russian origin.
|
15225161 |
2004 |
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We also analysed a large series of various brain tumours and found that in the group of astrocytic tumours, tenascin-R expression decreased with malignancy, whereas oligodendrogliomas sometimes retained a high level of tenascin-R even in high-grade tumours.
|
20202125 |
2010 |