Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Pancreatic carcinoma
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Pancreatic carcinoma
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Pancreatic carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We have examined the expression of the p53 and Rb-1 tumor-suppressor genes in seven human pancreatic carcinoma cell lines and 10 primary pancreatic carcinomas.
|
1630814 |
1992 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.
|
1764370 |
1991 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Coexistent inactivations of both MTS1 and p53 was common and suggests that abnormal regulation of cyclin-dependent kinases may play an important role in the biology of pancreatic carcinoma.
|
7726912 |
1994 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Archival cytology samples obtained from 17 patients with established pancreatic carcinoma were assayed for alterations in K-ras and p53.
|
7730480 |
1995 |
Pancreatic carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Both failed to specifically suppress p53 protein production in a cell-free assay system or to have any effect on mutant p53 expression by human pancreatic cancer cell lines.
|
7880719 |
1995 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although the rate of p53 mutations in pancreatic tumours is of the same order as in other adenocarcinomas (> or = 50%), an antibody response was found in only 5/78 (6.4%) sera from patients with pancreatic cancer.
|
7947080 |
1994 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Eight out of 30 tissues from primary pancreas cancer and 3 of 4 samples from metastases showed p53 mutations.
|
8026879 |
1994 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions.
|
8137263 |
1994 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma.
|
8194712 |
1994 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Immunohistochemical demonstration of the p53 tumour suppressor gene product in cancer of the pancreas and chronic pancreatitis.
|
8218996 |
1993 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data support a role for p53 gene alterations in human pancreatic cancer, and suggest that loss of its regulatory functions may constitute one of the differences between pancreatic cancer and chronic pancreatitis.
|
8513440 |
1993 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In pancreatic cancer mutations in oncogenes and tumor suppressor genes are frequently detected in p53 and K-ras.
|
8862512 |
1996 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Both genetic analysis and IP are required to characterize all p53 mutations in pancreatic cancer.
|
8927612 |
1996 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the therapeutic benefits of p53 expression by the transduction of wild-type p53 gene into p53-null human pancreatic carcinoma cells (AsPC-1).
|
9137421 |
1997 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Concurrent loss of p53 and K-ras function may contribute to the clinical aggressiveness of pancreas cancer.
|
9219065 |
1997 |
Pancreatic carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Nuclear accumulation of p53 correlates significantly with clinical features and inversely with the expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in pancreatic cancer.
|
9252195 |
1997 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data show that in some cases of chronic pancreatitis mutations in the p53 gene occur without morphological evidence of pancreatic cancer.
|
9529487 |
1998 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this study, the authors demonstrate that p53 positive cells precisely reflect its gene mutations, and also establish systematic procedures for the preoperative diagnosis of patients with pancreatic carcinoma.
|
9554525 |
1998 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The consequences of stable reintroduction of wt p53 on apoptosis and differentiation was examined in a poorly differentiated pancreatic carcinoma cell line (Panc-1), possessing only mutant (mt) p53 (codon 273 mutation).
|
9569027 |
1998 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Intraperitoneal delivery of a retroviral p53 vector may provide a novel treatment approach for peritoneal carcinomatosis from pancreatic cancer.
|
9706132 |
1998 |