Sarcoma
|
1.000 |
CausalMutation
|
group |
CGI |
|
|
|
Sarcoma
|
1.000 |
Biomarker
|
group |
HPO |
|
|
|
Sarcoma
|
1.000 |
CausalMutation
|
group |
CLINVAR |
|
|
|
Sarcoma
|
1.000 |
Biomarker
|
group |
BEFREE |
The p53 positivity in MFHs and other types of sarcoma indicates that p53 gene alterations may play a part in the neoplastic transformation of these tumours.
|
1333524 |
1992 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
In contrast to reported findings for other types of cancer, we found that mutations of the p53 gene in sarcomas are quite heterogeneous both in their distribution throughout the gene and in the type of genetic alterations that result.
|
1423262 |
1992 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
While "cancer families" are rarely identified when screening close relatives of sarcoma patients, the discovery of the currently known tumor suppressor gene syndromes associated with germ line retinoblastoma gene and p53 gene defects were made possible by their association with sarcomas.
|
1511024 |
1992 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
New germline mutations of the p53 gene are rare among patients with "sporadic" sarcoma but may be common in patients with sarcoma whose background includes either multiple primary cancers or a family history of cancer.
|
1565143 |
1992 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
In particular, the discovery of tumor suppressor gene syndromes, such as Rb1 gene and p53 gene defects manifested in "cancer families," were made possible by their association with sarcomas, otherwise rare tumors.
|
1932226 |
1991 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
Abnormalities of the p53 gene were found in several classes of soft tissue sarcoma, including leiomyosarcomas, rhabdomyosarcomas and malignant fibrous histiocytomas.
|
2216456 |
1990 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
In contrast, no alteration of the p53 gene was detected in 50 samples from other types of sarcomas.
|
2253237 |
1990 |
Sarcoma
|
1.000 |
AlteredExpression
|
group |
BEFREE |
Two of the sarcomas with rearranged genes expressed levels of p53 protein that were elevated relative to other tumors.
|
2823272 |
1987 |
Sarcoma
|
1.000 |
Biomarker
|
group |
BEFREE |
APC mutated (Min) mice develop large and small bowel adenomas, a small proportion of which, in time, become malignant. p53 deficient mice develop predominantly lymphoma and sarcoma.
|
7478622 |
1995 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
These data show that approximately 20% of sarcomas harbour TP53 gene alterations and illustrate a variety of TP53 gene mutation types.
|
7640047 |
1995 |
Sarcoma
|
1.000 |
AlteredExpression
|
group |
BEFREE |
Specific overexpression of P53 in sarcoma derived from Rat-1 cells transformed by cigarette smoking condensate-treated human fetal lung DNA.
|
7722886 |
1994 |
Sarcoma
|
1.000 |
AlteredExpression
|
group |
BEFREE |
Amplification of the MDM2 gene, which maps to chromosome band 12q13 and encodes a p53-binding protein, may result in functional inactivation of p53 and has been observed in various bone and soft tissue sarcomas.
|
7738717 |
1995 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
Our knowledge of the molecular biology of sarcomas has progressed considerably over the past year, with major emphasis on the role of p53 and MDM2 gene mutations.
|
7803538 |
1994 |
Sarcoma
|
1.000 |
AlteredExpression
|
group |
BEFREE |
Four affected members of the family with sarcoma or premenopausal breast cancer showed increased expression of p53 protein in their normal tissues as detected by immunohistochemistry.
|
7981072 |
1994 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
It is concluded that 17p deletions and TP53 mutations are common events in adult soft tissue sarcomas and that due to the trends observed with the cohort of patients analyzed they may become prognostic markers for patients affected with these tumors.
|
8053493 |
1994 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
We suggest that c-myc amplification and TP53 mutations do not seem to coparticipate in the tumorigenesis of sarcomas.
|
8076351 |
1994 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
The most common cancers occurring in the 41 families with germline p53 mutations, in common with classic LFS, were bone and soft tissue sarcoma, breast cancer, brain tumors, leukemia, and adrenocortical carcinoma, although less than one-half of the probands with germline p53 mutations came from classic LFS families.
|
8118819 |
1994 |
Sarcoma
|
1.000 |
AlteredExpression
|
group |
BEFREE |
We examined the potential clinical relevance of p53 overexpression in adults with soft-tissue sarcomas.
|
8133539 |
1994 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
However, there is little information about the clinicopathologic significance of alterations of the p53 gene in soft tissue sarcomas (STS).
|
8174045 |
1994 |
Sarcoma
|
1.000 |
GeneticVariation
|
group |
BEFREE |
These results demonstrated the dominance of the p53 mutations with null protein expression in bone and soft tissue sarcomas, showing a unique characteristic of these types of tumours compared with other malignancies such as colon carcinomas.
|
8260365 |
1993 |
Sarcoma
|
1.000 |
AlteredExpression
|
group |
BEFREE |
Overexpression of p53 was seen in 27 of 46 sarcomas (59%), including 26 of 41 (63%) mixed mesodermal tumors, one of four (25%) leiomyosarcomas, and zero of one endometrial stromal sarcoma.
|
8272291 |
1994 |
Sarcoma
|
1.000 |
AlteredExpression
|
group |
BEFREE |
This study was designed to determine the prevalence and potential clinical value of detected molecular abnormalities and altered patterns of expression of mdm2 and p53 genes in adult soft tissue sarcomas.
|
8306343 |
1994 |