Glioma
|
0.900 |
CausalMutation
|
disease |
CGI |
|
|
|
Glioma
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
1p19q LOH patterns and expression of p53 and Olig2 in gliomas: relation with histological types and prognosis.
|
20081802 |
2010 |
Glioma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Glioma development is accelerated upon loss of the tumor suppressor p53.
|
20360385 |
2010 |
Glioma
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy.
|
20661249 |
2010 |
Glioma
|
0.900 |
Biomarker
|
disease |
BEFREE |
A genomic analysis of the six genes identified in the glioma pathway by cBioPortal indicated that TMZ might exert biological effects via interaction with the tumor protein P53(TP53) signaling axis.
|
29152101 |
2017 |
Glioma
|
0.900 |
Biomarker
|
disease |
CTD_human |
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
|
21946351 |
2011 |
Glioma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A human glioma cell line (U-87MG) that expresses wild-type p53, one that expresses mutant p53 (T-98G), and a T-98G derivative (T-98G/p53) that was transfected with a wild-type p53 expression vector (pCDM8-p53/neo) were used.
|
10930016 |
2000 |
Glioma
|
0.900 |
Biomarker
|
disease |
BEFREE |
A human glioma cell line (A172/mp53) stably transfected with a plasmid containing mutated p53 and a human cervical cancer cell line (HeLa/bcl-2) transfected with a bcl-2 expression plasmid were used.
|
18640498 |
2008 |
Glioma
|
0.900 |
GeneticVariation
|
disease |
LHGDN |
A series of nine familial gliomas were characterized with 1-megabase resolution BAC array-based comparative genomic hybridization (aCGH) together with germline sequence analysis of TP53.
|
17656254 |
2007 |
Glioma
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
A significant correlation between the expression of mutant form of TP53 and the grade of the glioma was established.
|
20714943 |
2011 |
Glioma
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
A significant inverse correlation was observed between expression of miR-141-3p and p53 in glioma and normal brain tissues (R<sup>2</sup>=0.506, P<0.0001).
|
29050344 |
2017 |
Glioma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A specific TP53 low frequency variant has also been associated with glioma risk and validated in a separate data set.
|
24184969 |
2013 |
Glioma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A systematic screening for p53 mutations in surgical materials from patients with glioma revealed a 378C>G mutation that creates a stop codon at the position of amino acid residue 126.
|
28961258 |
2017 |
Glioma
|
0.900 |
Biomarker
|
disease |
BEFREE |
Absence of a functional p53 increases TMZ sensitivity in traditional glioma cell lines, an effect that is independent of MGMT status, and not seen in BTICs.
|
20593219 |
2011 |
Glioma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Absence of hereditary mutations in exons 5 through 9 of the p53 gene and exon 24 of the neurofibromin gene in families with glioma.
|
8285583 |
1994 |
Glioma
|
0.900 |
Biomarker
|
disease |
BEFREE |
All but one of the tumours with TP53 mutation showed p53 immunopositivity, but 5 low-grade and 10 high-grade gliomas had p53 protein nuclear accumulation in the absence of detectable mutation. p53 status was unrelated to p21 expression.
|
11355303 |
2001 |
Glioma
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Also, the p14(ARF) expression in p53 wild-type gliomas was lower than levels in p53 mutated gliomas.
|
12447702 |
2002 |
Glioma
|
0.900 |
Biomarker
|
disease |
BEFREE |
Also, we found that linarin-reduced cellular proliferation of glioma was dependent on p53 up-regulation and Nuclear factor kappa-B (NF-κB)/p65-down-regulation, thereby inhibiting glioma cell growth.
|
28858735 |
2017 |
Glioma
|
0.900 |
Biomarker
|
disease |
BEFREE |
Although it remains imperfect, p53 expression with a threshold of 10% is a good surrogate marker for missense TP53 mutations and appears helpful in the setting of LGG phenotype diagnosis.
|
24590827 |
2014 |
Glioma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Although mutation or inactivation of the p53 tumor suppressor gene occurs at early stages in gliomas and is associated with tumor progression, many tumors including high-grade glioblastoma multiforme carry a functionally intact p53 gene.
|
10100717 |
1999 |
Glioma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression.
|
8965097 |
1996 |
Glioma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
As mutations of the p53 tumor suppressor gene represent an early event in the development of gliomas, we attempted to determine whether both components of gliosarcomas share identical alterations of the p53 gene.
|
7666053 |
1995 |
Glioma
|
0.900 |
Biomarker
|
disease |
BEFREE |
Association of p53 tumor suppressor gene with paraclinical and clinical modalities of gliomas patients in Malaysia.
|
15168228 |
2004 |
Glioma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Association of p53 Arg72Pro and MDM2 SNP309 polymorphisms with glioma.
|
23096687 |
2012 |
Glioma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma.
|
16818615 |
2006 |