ovarian neoplasm
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
ovarian neoplasm
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
ovarian neoplasm
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
2774 human ovarian cancer cell line that contains a p53 mutation.
|
9648587 |
1998 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Ovarian cancer p53 mutation is associated with tumor microvessel density.
|
12079305 |
2002 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Ovarian cancer is characterized by frequent mutations at TP53.
|
28847989 |
2017 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Ovarian cancer genomic instability correlates with p53 frameshift mutations.
|
9067268 |
1997 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
TP53 and P21 polymorphisms: response to cisplatinum/paclitaxel-based chemotherapy in ovarian cancer.
|
16364249 |
2006 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
TP53 mutations and codon 72 genotype--impact on survival among ovarian cancer patients.
|
17488735 |
2007 |
ovarian neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
Tumor suppressor p53 is frequently deleted or mutated in aggressive and high-grade ovarian cancer, probably aggravating cancer progression and increasing mortality.
|
23300534 |
2012 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer.
|
25916844 |
2015 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
TP53 mutation is a common event in EOC, particularly in high-grade serous ovarian cancer, where it occurs in more than 90% of cases.
|
26986846 |
2016 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
TP53 Mutations in Breast and Ovarian Cancer.
|
27815305 |
2017 |
ovarian neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
TP53 pathway may play pivotal roles in the development of ovarian cancer and TP53 pathway may be a new target for the treatment of ovarian cancer.
|
29565482 |
2018 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A 19 base pair deletion in exon 5 of the p53 gene was detected in one ovarian tumor.
|
9671178 |
1998 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A high frequency of p53 mutations in ovarian cancers and lack of mutation in 6 benign ovarian tumors and 2 normal ovaries suggested that the mutation of the p53 gene was associated with the genesis and/or progression of ovarian cancer.
|
1333465 |
1992 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A more detailed analysis of these somatic mutations revealed a set of genes that are mutated in human BRCA2 mutant breast and ovarian tumours and that are also mutated in mouse Brca2-null, Trp53-null mammary tumours.
|
25692405 |
2015 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A possible functional impairment of the p53 pathway caused by the G/G genotype of the MDM2 SNP309 may modify the association between p53 mutational status and prognosis in ovarian cancer.
|
22134502 |
2012 |
ovarian neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
A search of three public databases using keywords combined with Boolean operators identified 64 clinical publications investigating the relationship of p53 to clinical outcome following chemotherapy in ovarian cancer.
|
15147608 |
2004 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
A shift from one p53 intron 2 genotype in the blood to another genotype in the tissue may be a prognostic factor in ovarian cancer patients.
|
12926080 |
2003 |
ovarian neoplasm
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
A significant inverse correlation between Bcl-2 and p53 expression was found in the malignant ovarian tumors examined. p53 gene mutation at exons 5-11 was however not a pre-requisite for p53 expression in both borderline and malignant tumors.
|
10666369 |
2000 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Abnormal expression of the retinoblastoma gene in ovarian neoplasms and correlation to p53 and K-ras mutations.
|
7545631 |
1995 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Absence of significant germ line p53 mutations in ovarian cancer patients.
|
7672703 |
1995 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
According to the International Agency for Research on Cancer TP53 mutation database, this type of p53 mutation in colorectal cancer and ovarian cancer is 0.13% (5/3,693) and 0% (0/1,494), respectively.
|
20514505 |
2010 |