ovarian neoplasm
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
ovarian neoplasm
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
ovarian neoplasm
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
ovarian neoplasm
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
As in other cancers, overexpression of the p53 protein in ovarian cancer appears to correlate closely with the presence of mutation in the p53 gene. p53 overexpression did not correlate with stage, histological grade, or the ability to perform optimal cytoreductive surgery.
|
2032235 |
1991 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Involvement of p53 gene in the allelic deletion of chromosome 17p in human ovarian tumors.
|
1776830 |
1992 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A high frequency of p53 mutations in ovarian cancers and lack of mutation in 6 benign ovarian tumors and 2 normal ovaries suggested that the mutation of the p53 gene was associated with the genesis and/or progression of ovarian cancer.
|
1333465 |
1992 |
ovarian neoplasm
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In this series of ovarian tumours, LOH on 17p correlates closely with the aberrant expression of the p53 protein in a high proportion of advanced stage serous adenocarcinomas.
|
1310251 |
1992 |
ovarian neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
High incidence of p53 gene mutation in human ovarian cancer and its association with nuclear accumulation of p53 protein and tumor DNA aneuploidy.
|
1429209 |
1992 |
ovarian neoplasm
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In breast cancer, by contrast with colorectal, lung and ovarian cancer, there appears to be no clear association between p53 DNA abnormalities and p53 expression.
|
1537617 |
1992 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We have investigated a series of ovarian tumours for evidence of mutations in the p53 tumour suppressor gene.
|
8422653 |
1993 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Using the single-strand conformational polymorphism technique, we have screened 66 malignant ovarian tumors for p53 mutation in exons 5 to 8.
|
8481915 |
1993 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer.
|
8360934 |
1993 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This is the first report of germ line p53 mutations associated with familial ovarian cancer and indicates that this gene may play a role in the development of some familial ovarian cancers.
|
7903948 |
1993 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To clarify the role of the p53 tumor suppressor gene in the development of human ovarian epithelial tumors and to study the association of p53 alterations with K-ras activation, a series of 70 common epithelial ovarian tumors from Japanese patients was studied.
|
7852189 |
1994 |
ovarian neoplasm
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The aim of this investigation was to study the prevalence of p53 gene mutations and allelic deletions in ovarian cancer and the relationship between these events and p53 expression.
|
7823248 |
1994 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Introduction of mutant p53 did not alter the morphology or growth characteristics of this ovarian cancer cell line.
|
8152906 |
1994 |
ovarian neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results suggest that p53 abnormalities may be early events in ovarian cancer, possibly contributing to malignant transformation of some borderline tumors, endometriosis and other carcinoma precursors.
|
7942635 |
1994 |
ovarian neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
This review discusses recent insights into the roles of the p53 tumor-suppressor gene and growth factors in the development of ovarian cancer and describes the genes implicated in familial ovarian cancer syndromes related to the MSH2 (Lynch II) and BRCA1 (breast and ovarian cancer) genes.
|
7827156 |
1994 |
ovarian neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
Alteration of p53 in ovarian cancer: its occurrence and maintenance in tumor progression.
|
7814192 |
1994 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To determine the feasibility of mutant p53 as a molecular target for gene therapy in ovarian cancer, we constructed an adenovirus vector containing the wild-type p53 gene.
|
7590467 |
1995 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Abnormal expression of the retinoblastoma gene in ovarian neoplasms and correlation to p53 and K-ras mutations.
|
7545631 |
1995 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Other high-risk cancer genes that confer increased risks of breast or ovarian cancer in addition to other cancers include the hereditary non-polyposis colorectal cancer genes and the TP53 gene, which causes breast cancer as part of the Li-Fraumeni syndrome.
|
7547224 |
1995 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Reasoning that molecular markers of ovarian malignancy would be confined to the histologically malignant portions of cystadenocarcinomas if the morphologically benign portions are in fact pre-existing typical cystadenomas, we sought to verify that mutations in the p53 tumor suppressor gene are markers of malignancy in ovarian tumors and to determine the distribution of such mutations in cystadenocarcinomas.
|
7674319 |
1995 |
ovarian neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Absence of significant germ line p53 mutations in ovarian cancer patients.
|
7672703 |
1995 |