TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Disease: Pancreatic Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 Biomarker disease HPO
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 CausalMutation disease CGI
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 Biomarker disease CTD_human
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 AlteredExpression disease BEFREE With the aid of a newly developed target unmasking fluid (TUF), p53 overexpression was visualized by immunohistochemistry on recent and archival paraffin-embedded tissue samples of colon, stomach, and pancreas neoplasms. 8434637 1993
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 Biomarker disease BEFREE This is the first time that concomitant point mutations in c-N-ras and p53 have been found in a neuroendocrine pancreatic tumor. 9042254 1997
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 Biomarker disease BEFREE Treatment of nude mice with the retroviral p53 vector resulted in a significant inhibition of growth of the primary pancreatic tumor, as well as the peritoneal tumor deposits, compared with the LXSN control vector. 9706132 1998
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 GeneticVariation disease BEFREE Mutation of the p53 tumor suppressor gene is found in a large number of exocrine pancreatic tumors. 9436856 1998
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 GeneticVariation disease BEFREE Gene therapy approaches involving p53 replacement are promising due to the central role of p53 in the cellular response to DNA damage and the high incidence of p53 mutations in pancreatic tumors. 10505853 1999
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 GeneticVariation disease BEFREE Both K-ras and p53 gene mutations are found commonly in pancreatic tumors. 10217065 1999
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 AlteredExpression disease BEFREE Reduced expression of p53 and cyclin A in intraductal mucin-hypersecreting neoplasm of the pancreas compared with usual pancreatic ductal adenocarcinoma. 10445560 1999
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 GeneticVariation disease BEFREE This study was undertaken to evaluate the impact of wild-type or mutant p53 status on the synergistic effects of 5-Fluorouracil (5-FU) and radiation (XRT) in pancreatic tumors. 12014658 2002
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 Biomarker disease BEFREE This suggests that LKB1-induced apoptosis is p53 independent but might be p73-mediated in the pancreatic tumor cell line, AsPC-1. 14511408 2004
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 GeneticVariation disease LHGDN Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. 15846069 2005
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 GeneticVariation disease LHGDN Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs. 17106238 2006
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 GeneticVariation disease LHGDN Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer. 17659731 2007
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 GeneticVariation disease LHGDN Pancreatic tumor cell lines, CRL1420, which contains elevated levels of mutant p53, and CRL1682, with no detectable p53 protein, were stably transfected with the exogenous wild-type p53 gene. 17651038 2007
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 AlteredExpression disease BEFREE Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. 17911264 2007
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 AlteredExpression disease LHGDN Expression of Gadd45a and p53 proteins in human pancreatic cancer: potential effects on clinical outcomes. 17230496 2007
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 GeneticVariation disease LHGDN Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations. 18701504 2008
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 GeneticVariation disease BEFREE Furthermore, the identical nucleotide mutation of TP53 gene was observed from both the endometrial and pancreatic tumors. 18577117 2008
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 GeneticVariation disease BEFREE Surprisingly, little is known about the role and regulation of hdm2 in pancreatic tumors, a large proportion (50-75%) of which contain mutant p53. 19029954 2009
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 AlteredExpression disease LHGDN Surprisingly, little is known about the role and regulation of hdm2 in pancreatic tumors, a large proportion (50-75%) of which contain mutant p53. 19029954 2009
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 AlteredExpression disease BEFREE Collectively, our results show that decreased MGMT expression is correlated with p53 activation, and significantly reduced primary pancreatic tumor growth. 19789303 2009
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 Biomarker disease BEFREE Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. 24875860 2014
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.900 Biomarker disease CTD_mouse Functions of TAp63 and p53 in restraining the development of metastatic cancer. 23873029 2014