TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 GeneticVariation group BEFREE We have studied a series of 100 primary colorectal adenocarcinomas by immunohistochemistry with the monoclonal antibody PAb1801, and single-stranded conformation polymorphism (PCR-SSCP, exons 4-8) followed by direct sequencing of shifted bands. p53 Nuclear staining was undetectable (score 0) in 29 of 100 cases. 12777996 2003
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 GeneticVariation group BEFREE This study shows that p53 alterations are more frequent in adenocarcinoma of the cardia than in adenocarcinoma of the antrum. 10748875 1999
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker group BEFREE Furthermore, the score was able to predict recurrence-free survival in patients with stage I adenocarcinoma and was also associated with smoking status.<b>Conclusions:</b> The P53 deficiency score was a better predictor of recurrence-free survival compared with P53 mutation status and provided additional prognostic values to established clinical factors.<b>Impact:</b> The P53 deficiency score can be used to stratify early-stage patients into subgroups based on their risk of recurrence for aiding physicians to decide personalized therapeutic treatment. 29141854 2018
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker group BEFREE Immunostaining for p53 protein with 4 different antibodies was performed on paraffin-embedded specimens from 69 patients with adenocarcinoma and squamous cell carcinoma of the oesophagus. 10948341 2001
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 AlteredExpression group BEFREE Abnormalities of the tumour suppressor gene p53 have been shown in approximately 60% of advanced gastric adenocarcinomas and it has been suggested that the immunohistochemical finding of increased p53 expression is a prognostic marker in gastric cancer. 7829004 1994
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 GeneticVariation group BEFREE A total of 297 resected Japanese non-small cell lung cancers (74 squamous cell carcinomas and 223 adenocarcinomas) were analyzed to evaluate the validity of the p53 mutation spectrum as a fingerprint for mutagenic substances as etiological factors. 18271927 2008
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 GeneticVariation group BEFREE VEGF was expressed in 50% of the squamous cell carcinomas (SCC) and carcinoids but none of the others. p53 mutations occurred in 14 tumours (52%), and K-ras mutations were found in two adenocarcinomas and one SCC; there was no correlation between the mutations and VEGF expression. 9683299 1998
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 AlteredExpression group BEFREE Korean prostatic adenocarcinomas showed higher Gleason scores, lower rates of HPIN and multifocality, and lower p53 expression in comparison to Western prostatic adenocarcinomas. 12806373 2003
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 GeneticVariation group BEFREE No K-ras or p53 mutations were determined in the two microsatellite instable adenocarcinomas. 12559075 2003
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker group BEFREE By contrast, mice with both alterations (Hoxb13-MYC∣Hoxb13-Cre∣Pten(Fl/Fl), hereafter, BMPC mice) developed lethal adenocarcinoma with distant metastases and widespread genome CNAs that were independent of forced disruption of Tp53 and telomere shortening. 26554830 2016
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker group BEFREE To examine in vivo the validity of the results of experiments in vitro, we analyzed the relationship between p53 gene status and apoptotic cell death of human gastric intestinal-type adenocarcinomas. 9247603 1997
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 GeneticVariation group BEFREE 46/103 (44.6%) NSCLC showed p53 mutations and 17/103 (16.5%) c-Ki-ras mutations including 12/37 (32.4%) adenocarcinomas. 10945494 2000
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 GeneticVariation group BEFREE Nine patients (25.7%) with SCC and 6 patients (23.1%) with Ad were shown to have mutations of the p53 gene by single-strand conformation polymorphism. 10023701 1999
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker group BEFREE We conclude that Fbw7 and p53 synergistically suppress adenocarcinomas that mimic advanced human CRC with respect to histopathology, metastasis, and CIN. 22473991 2012
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker group BEFREE We examined the expression pattern of the AID and p53 proteins in 186 gastric adenocarcinomas by immunohistochemistry. 18391550 2007
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 AlteredExpression group BEFREE To assess potential clinical applications for molecular genetic markers associated with human esophageal tumorigenesis, ten patients with primary esophageal adenocarcinomas were studied prospectively to evaluate expression of the p53 and H-ras genes. 8076380 1994
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 AlteredExpression group BEFREE The immunohistochemical finding of p53 protein in primary esophageal adenocarcinomas and regional lymph node metastases appears to be associated with reduced overall survival for this disease. 7666667 1995
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 AlteredExpression group BEFREE These results suggest that COX-2 expression might play an important role in ovarian cancer development and that COX-2 expression in ovarian adenocarcinomas is frequently associated with p53 protein accumulation. 12469191 2003
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 GeneticVariation group BEFREE Colorectal adenocarcinomas from 137 African Americans and 236 non-Hispanic Caucasians were assessed for p53 mutations and genotyped for the codon 72 polymorphism. 19339276 2009
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 GeneticVariation group BEFREE An increase in the NSCLC risk posed by the p53 Pro allele (versus Arg/Arg) was seen in AC compared with controls [adjusted odds ratio (OR), 1.36; 95% confidence interval (CI), 1.1-1.7] but not in SCC (adjusted OR, 1.04; 95% CI, 0.8-1.4). 11751390 2001
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 GeneticVariation group BEFREE Using comparative genomic hybridization and mutational analysis of APC, KRAS, and TP53 to evaluate 78 colorectal adenomas, we have shown that several of the significant relationships between gene mutations and chromosomal abnormalities reported in colorectal adenocarcinomas also exist at the adenomatous stage. 16235243 2006
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker group BEFREE However, p53 appeared to be a late marker in the neoplastic transformation, and no p53 change was found in approximately 25% of the adenocarcinoma. 17982662 2007
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker group BEFREE Strong immunoreactivity of Bcl-2 and mild immunoreactivities of Bax and p53 were detected in ovarian adenocarcinomas. 25108507 2014
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker group BEFREE The overall survival rate of patients with mutations in exon 7 was worse than that of patients with wild-type p53 in NSCLCs and adenocarcinomas (42.9% vs 56.0%; P=0.025 and 33.3% vs 53.8%; P=0.048, respectively), whereas the overall survival of patients with mutations in exon 5 was almost the same as that of patients with wild-type p53. 9627113 1998
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker group BEFREE To study the relative contribution of each pathway in tumorigenesis, we analysed and compared alterations of the p16, p14ARF and p53 genes in 38 primary non-small cell lung cancers (NSCLCs) (19 adenocarcinomas and 19 squamous carcinoma). 10557071 1999