|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
To review the existing literature analysing the influence of radon exposure on mutations in tumour protein 53 gene (TP53) in lung cancer patients.
|
19479602 |
2009 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This retrospective observational study examined lung cancer tumor samples from 163 H/L patients, and tumor-derived DNA was subjected to targeted-exome sequencing (>1000 genes, including EGFR, KRAS, serine/threonine kinase 11 gene [STK11], and tumor protein p53 gene [TP53]) and ancestry analysis.
|
28911955 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Complete sequence of p53 gene in 20 patients with lung cancer: comparison with chemosensitivity and immunohistochemistry.
|
9951689 |
1998 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the P53 tumour suppressor gene in primary lung cancer in Japan.
|
1348931 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The overall pooled ORs showed no significant relationship of the p53 codon 72 polymorphism with increased or decreased risk of lung cancer in all gene contrast models (OR Pro vs. Arg = 1.04, 95 % CI = 0.96-1.13, P OR < 0.001; OR Pro/Pro vs. Arg/Arg = 1.07, 95 % CI = 0.91-1.25, P OR < 0.001; OR Arg/Pro vs. Arg/Arg =1.04, 95 % CI = 0.94-1.15, P OR < 0.001; OR Pro/Pro + Arg/Pro vs. Arg/Arg = 1.04, 95 % CI = 0.94-1.16, P OR < 0.001; OR Pro/Pro vs. Arg/Arg + Arg/Pro = 1.07, 95 % CI = 0.93-1.23, P OR < 0.001).
|
23715779 |
2013 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Overall, we did not observe any variant homozygotes in this study population, nor significant associations between the TP53 rs78378222AC genotype or C allele and risk for melanoma (P = 0.680 and 0.682 respectively) and lung cancer (P = 0.379 and 0.382 respectively), but a protection against SCCHN (P = 0.008 and 0.008 respectively), compared with the AA genotype or A allele.
|
23742673 |
2013 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
CS correlates with several lung cancer risk factors, including histopathological grade, age, smoking status, and p53 and Ki67 immunostaining.
|
22277916 |
2012 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The present study examines the ethnic differences in the type and frequency of MET proto-oncogene (MET) mutation in lung cancer and correlated them with other frequently mutated genes such as epidermal growth factor receptor (EGFR), KRAS2, and TP53.
|
19723643 |
2009 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
After adjusting gender and tumor type, the major contributors to p53 degradation in lung cancer patients were determined to be p53 codon72 polymorphism and HPV 16/18 E6 oncoprotein expression.
|
23522190 |
2013 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
When we analyzed the HLA subtype of lung cancer cell lines with known p53 missense mutations, we found that all of the mutant oncopeptides predicted to be presentable by HLA A*0201 came from tumors that either did not carry the A*0201 allele or had lost that allele in the process of tumorigenesis.
|
8118802 |
1994 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The mutation frequency (46%) of the p53 gene in tumors carrying mutated ras genes was essentially the same as the overall frequency in lung cancers, suggesting that accumulation of mutations in these two genes in a tumor is a random phenomenon.
|
1324794 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Simultaneous cellular and humoral immune response against mutated p53 in a patient with lung cancer.
|
15067062 |
2004 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Loss of TP53-DNA interaction induced by p.C135R in lung cancer.
|
17914575 |
2007 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Taken together, more than half (55% and 56% for lung cancer and bladder cancer, respectively) of the patients who continued smoking (CS), less than 40% (38% and 38%) of those who had stopped smoking before > or = 1 or > or = 5 years) clinical diagnosis (ES), and less than 30% (25% and 29%) of those who were nonsmokers (NS) had a p53 mutation.
|
8781382 |
1996 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In this study, using both novel and established technologies, we developed a clinically practical assay to survey the status of three frequently mutated genes in lung cancer (EGFR, K-ras and TP53) and two genes (BRAF and β-catenin) with known hotspot mutations in many other cancers.
|
22407457 |
2012 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In addition, TP53 mutations in Korean patients with lung cancers have not been investigated.
|
20436704 |
2010 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Because the p53 molecular mutation involved in tumorigenesis of patients with lung cancer in Taiwan remains poorly defined, the aim of this study was to assess the p53 mutation spectrum and possible etiological factors of Taiwan's patients with Non-Small Cell Lung Cancer (NSCLC).
|
15863268 |
2005 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We evaluated 23 single nucleotide polymorphisms (SNPs) in the five nicotinic receptor related genes (CHRNB3, CHRNA6, and CHRNA5/A3/B4) previously reported to be associated with lung cancer risk and smoking behavior and 14 SNPs in the four 'control' genes (TERT, CLPTM1L, CYP1A1, and TP53), which were not reported in the smoking GWA studies.
|
25233467 |
2014 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The mutation profiles of p53 and K-ras genes in pancreatic cancer resemble that in bladder cancer rather than that in lung cancer.
|
11561602 |
2002 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We observed an increased risk of a variety of histological types of lung cancer in the carriers of the p53 germline mutation.
|
12802680 |
2003 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
On the basis of the novel findings presented in this study, we modified the original serological analysis of antigens by recombinant cDNA expression cloning design in a patient with lung cancer who expressed unusually favorable clinical evolution and analyzed humoral immunity against identified mutated p53 antigen.
|
11912150 |
2002 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The imbalance between the long and short arms of chromosome 3 was determined in 24 cases of non-small-cell and small-cell lung cancers in which only small snap-frozen sections were used, allowing other simultaneous molecular analyses, such as TP53 gene mutation detection.
|
15507848 |
2004 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
To determine the association between expression of TRAIL-R2 and p53 mutation status in lung cancers, we compared the two events in 20 small-cell lung cancer (SCLC) cell lines, 20 NSCLC cell lines, and 30 primary NSCLC tumors.
|
11205299 |
2001 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk.
|
19129997 |
2009 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Three of 23 mutations were nonsense mutations; to date, nonsense mutations of p53 have not been reported in lung cancer.
|
1312896 |
1992 |