|
Malignant neoplasm of lung
|
0.800 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
These findings, coupled with the previous demonstration of 17p allele loss in lung cancer, strongly implicate p53 as an anti-oncogene whose disruption is involved in the pathogenesis of human lung cancer.
|
2554494 |
1989 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Mutation of the p53 gene is the most frequently identified genetic change in human lung cancer; these findings suggest that simple immunohistological methods can provide strong evidence of such mutation.
|
1969059 |
1990 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
However, the presence of p53 mutations was not significantly associated with tumor stage, nodal status or sex and was found in all histologic types of lung cancer.
|
1979160 |
1990 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
A chemical mismatch cleavage method useful for the detection of point mutations in the p53 gene in lung cancer.
|
2223098 |
1990 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The high incidence of loss of 17p (14 of 21 specimens) appears to be compatible with reports implicating the TP53 gene (at band 17p13) as a frequent site for genetic alteration in lung cancer.
|
2176544 |
1990 |
|
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
These findings further support the role of inactivation of the p53 gene in the pathogenesis of lung cancer and indicate the role of intronic point mutation in this process.
|
2164047 |
1990 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Thirteen of 14 nucleotide residues of the p53 gene which underwent G:C to T:A mutations in lung cancers were targeted by benzo(a)pyrene.
|
1933877 |
1991 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the P53 tumour suppressor gene in primary lung cancer in Japan.
|
1348931 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The mutation frequency (46%) of the p53 gene in tumors carrying mutated ras genes was essentially the same as the overall frequency in lung cancers, suggesting that accumulation of mutations in these two genes in a tumor is a random phenomenon.
|
1324794 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Three of 23 mutations were nonsense mutations; to date, nonsense mutations of p53 have not been reported in lung cancer.
|
1312896 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
PosttranslationalModification
|
disease |
BEFREE |
These results indicate that mutation of the p53 tumor suppressor gene plays an important role in the development of primary lung cancer, and that nuclear accumulation of p53 protein is a potential prognostic factor in adenocarcinoma of the lung.
|
1544866 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Relationship of H-ras-1, L-myc, and p53 polymorphisms with lung cancer risk and prognosis.
|
1486864 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
The p53 gene has been implicated as a tumor suppressor gene involved in the pathogenesis of lung cancer.
|
1310070 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
None of these lung cancer patient sera had measurable amounts of p53 antigen.
|
1322237 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Acquired mutations in the p53 tumor-suppressor gene have been detected in several human cancers, including colon, breast, and lung cancer.
|
1565144 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
None of the mutations were G:C to T:A transversions in the coding strand of the p53 gene, which are the most frequent base substitutions associated with tobacco smoking, and none were found at the hotspot codons described in lung cancer.
|
1347094 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
We conclude that there are low- and high-expression groups of p53 mutants in lung cancer and that the detection of protein expression in tumor cells by immunocytochemistry and immunoblotting is dependent upon the type of mutation of the p53 tumor-suppressor gene.
|
1565469 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
In contrast, p53 expression vectors bearing lung cancer derived mutations affecting single amino acids had lost this growth suppressing ability.
|
1559236 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Strikingly, a variety of lung cancer derived p53 mutations occurring outside this domain disrupt this activity.
|
1314165 |
1992 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
A retroviral vector-mediated system was established to allow efficient transduction of the wild-type p53 gene into human lung cancer cell lines H358a (deleted p53) and H322a (mutant p53).
|
8280799 |
1993 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our results show: (1) wild-type p53 stimulates the transcription of reporter genes with p53CON and RGC in their 5' region while most p53 mutants occurring in human cancers have lost this activity; (2) the R273H mutant retains transcriptional activity for the p53CON sequence but not RGC; (3) some mutants are temperature-sensitive for the transcriptional activity with the p53CON but not the RGC sequence; (4) p53 mutants vary in their ability to inhibit wild-type p53 transactivation but there is no difference between p53CON and RGC sequences; (5) lung cancer cells with endogenous mutant p53 proteins (M246I in H23 cells and R248L in H322 cells) retain transcriptional activity for the p53CON but not the RGC sequence.
|
8336941 |
1993 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
We compiled a mutational spectrum of p53 from 120 breast cancers and compared it with the spectrum from 145 colorectal cancers and 246 lung cancers.
|
8377645 |
1993 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Allelic frequency of a p53 polymorphism in human lung cancer.
|
1302561 |
1993 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that point mutations of the p53 gene are infrequent in pulmonary carcinoids thus contrasting the findings in other histological types of lung cancer, in particular small-cell lung cancer.
|
8242638 |
1993 |