|
metastatic pheochromocytoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Simultaneous Occurrence of Germline Mutations of SDHB and TP53 in a patient with Metastatic Pheochromocytoma.
|
31851316 |
2020 |
|
Acrocallosal Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, p53 deficiency or accumulated mutations are not the causes of aCLS cancers.
|
31647999 |
2020 |
|
Low grade appendiceal mucinous neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The 10 cases of MACA harbored a similar prevalence of TP53 mutations (n=5, 50%) as HAMN but, unlike LAMN and HAMN, some harbored mutations in PIK3CA, APC, FBXW7, PTEN, and SMAD4.
|
31491041 |
2020 |
|
Metastatic Adrenal Gland Pheochromocytoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Simultaneous Occurrence of Germline Mutations of SDHB and TP53 in a patient with Metastatic Pheochromocytoma.
|
31851316 |
2020 |
|
Prostate cancer, familial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of p53, Bcl-2, Ki67, and other immunohistochemistry biomarkers revealed that only increasing p53 expression and first-degree familial PCa approached significance (P = .059).
|
31664733 |
2020 |
|
Stage III Colorectal Cancer AJCC v7
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we examined the predictive utility of TP53 overexpression in the context of current adjuvant treatment practice for patients with stage III colorectal cancer.
|
31471586 |
2020 |
|
Anorectal Malformations
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Western blotting and RT-qPCR confirmed the decrease in MYC and increase in p53 expression in ARMs.
|
31787253 |
2020 |
|
Diminished ovarian reserve
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations in CHD5 (c.-140A>C), RB1 (c.1422-18delT, rs70651121), and TP53 (c.376-161A>G, rs75821853) were found at significantly higher frequencies in DOR cases compared to controls (p ≤ 0.05).
|
31792669 |
2020 |
|
Hereditary Prostate Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of p53, Bcl-2, Ki67, and other immunohistochemistry biomarkers revealed that only increasing p53 expression and first-degree familial PCa approached significance (P = .059).
|
31664733 |
2020 |
|
Bipolar Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aim to determine the association of TP53 polymorphisms, rs1042522 and rs17879353, with the susceptibility to schizophrenia (SCZ) or bipolar disorder (BD) in Chinese Han population.
|
31055723 |
2019 |
|
Cachexia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Protein levels of phosphorylated p53 (Ser46), activated caspase 8 (Asp384) and 9 (Asp315) were also increased in the skeletal muscle of CC.
|
31466311 |
2019 |
|
Carcinoma, Ehrlich Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overall, TCCP was shown to be efficient in inducing ROS and mitochondrial-mediated apoptosis by restoring p53 activity in MDA-MB-231 cells and also induced EAT cell death in vivo thereby inhibiting tumor proliferation.
|
30543781 |
2019 |
|
Cystic Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Upstream regulator analysis indicated dysregulation of CCL5, NF-κB and IL1A due to CF while dysregulation of TREM1 and TP53 regulators were associated with CF phenotype.
|
31118097 |
2019 |
|
Diarrhea
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Overall, the present study reveals that chemotherapeutic selectivity conferred by SeNPs involves a dual suppression of two well-documented targets, the p53 and thrombospondin-1, providing mechanistic and pharmacologic insights on low-toxicity SeNPs as a potential chemoprotectant for mitigating chemotherapy-induced diarrhea.
|
31593755 |
2019 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
SIRT1 appears to interact with p53 to improve muscle fatigue resistance after repair from muscle injury.
|
31197980 |
2019 |
|
Friedreich Ataxia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The binding of p53 to this region was confirmed using chromatin immunoprecipitation in human Friedreich's ataxia fibroblast and adenocarcinoma cells.
|
31159174 |
2019 |
|
Intestinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Remarkably, we found that <i>VE-cadherin-Cre; p53<sup>FL/FL</sup></i> mice, in which both alleles of p53 are deleted in endothelial cells, were not sensitized to the acute GI radiation syndrome, but these mice were highly susceptible to delayed radiation enteropathy.
|
31265788 |
2019 |
|
Marfan Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared with control-VPCs, MFS-VPCs exhibited cellular senescence as demonstrated by increased cell size, higher SA-β-gal activity and elevated levels of p53 and p21.
|
30920150 |
2019 |
|
Mastitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
It was concluded that Brassica oleracea may be a promising candidate to be included in a mammalian herbal cocktail against infectious bovine mastitis by interfering in the mechanisms of action of genes such as MTOR and TP53.
|
30685362 |
2019 |
|
Neurodermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In particular, p53 parabasal and mid-epithelial staining without involvement of the basal layer appears to be a characteristic finding in CVIN with superimposed LSC.
|
29750709 |
2019 |
|
Ocular Hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overexpression also increased survival of cells subjected to oxidative stress linked to ocular hypertension, associated with TP53 pathway activation.
|
30855200 |
2019 |
|
Paresis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In light of these results, we conclude that p53 expression in skeletal muscle fibers has minimal if any direct, cell autonomous effect on basal or age-related changes in skeletal muscle mass and function up to at least 22 mo of age.<b>NEW & NOTEWORTHY</b> Previous studies implicated the transcriptional regulator p53 as a potential mediator of age-related skeletal muscle weakness and atrophy.
|
31465716 |
2019 |
|
Pemphigus Vulgaris
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings suggest a novel role for Dsg3 as an anti-stress protein, via suppression of p53 function, and this pathway is disrupted in PV.
|
31582719 |
2019 |
|
Psychotic Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
TP53 has been reported to be involved in diverse neurological processes related to the pathogenesis of psychosis.
|
31055723 |
2019 |
|
Lichen Simplex Chronicus
|
0.010 |
Biomarker
|
disease |
BEFREE |
In particular, p53 parabasal and mid-epithelial staining without involvement of the basal layer appears to be a characteristic finding in CVIN with superimposed LSC.
|
29750709 |
2019 |