Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Surprisingly, the p53<sup>53,54</sup> TAD2 mutant behaves as a "super-tumor suppressor," with an enhanced capacity to both suppress pancreatic cancer and transactivate select p53 target genes, including Ptpn14.
|
29017057 |
2017 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The relationship between TG2 and p53 suggests a possible mechanism for glucose tolerance abnormalities-associated pancreatic cancer and could have therapeutic potential for cancer treatment and diagnosis.
|
29088786 |
2017 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this issue of Cancer Cell, Mello et al. investigated how p53 suppresses pancreatic cancer and discovered a key role for the tyrosine phosphatase PTPN14, a p53 transcriptional target.
|
29017051 |
2017 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice.
|
26411367 |
2016 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Previous findings have shown that the tumor suppressor p53 is involved in the development of various types of cancer, including pancreatic cancer.
|
26531836 |
2016 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway.
|
26683776 |
2016 |
Pancreatic carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Enhanced phosphorylation of p53 by microRNA-26a leading to growth inhibition of pancreatic cancer.
|
26189069 |
2015 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be important in pancreatic cancer (TP53, SMAD4, CDKN2A, ARID1A and ROBO2) and new candidate drivers of pancreatic carcinogenesis (KDM6A and PREX2).
|
25719666 |
2015 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Other genetic alterations, including telomere shortening and the inactivation of tumor suppressor genes such as CDKN2A, TP53, and SMAD4, which encode p16, p53, and SMAD4, respectively, also contribute to the progression of pancreatic cancer.
|
24445769 |
2015 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The hypothesis in question can be tested if the DNA of P. gingivalis or the antibodies against P. gingivalis can be detected in patients with the p53 arginine mutation.If this hypothesis is true, it could reveal the real cause of pancreatic cancer, which is a fatal disease.
|
26617937 |
2015 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We previously observed an association between TP53 haplotypes based on four polymorphisms (rs17878362, rs1042522, rs12947788, and rs17884306) and the risk of colorectal and pancreatic cancer.
|
26226484 |
2015 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 in patients with pancreatic cancer.
|
25479140 |
2015 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings highlight p53 status in pancreatic cancer as a biomarker to predict sensitivity to LDH-A inhibition, with regard to both real-time noninvasive imaging by 13C MRS as well as therapeutic response.
|
26113084 |
2015 |
Pancreatic carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our data indicate that PRIMA-1 induces apoptosis in p53 mutant pancreatic cancer cells by promoting the re-activation of p53 and inducing proapoptotic signaling pathways, providing in vitro evidence for a potential therapeutic approach in pancreatic cancer.
|
24838627 |
2014 |
Pancreatic carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Overexpression of Gli1, MDM2 and mutant p53 contributes to the development and progression of PC, and plays an important role in predicting PC patients' prognosis.
|
24289472 |
2014 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our study first demonstrated that overexpression of CRT contributed to the development and progression of PC through MEK/ERK-signaling pathway but independent of p53.
|
24264800 |
2014 |
Pancreatic carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We show that sustained expression of mutant p53 is required to maintain the prometastatic phenotype of a murine model of pancreatic cancer, a highly metastatic disease that frequently displays p53 mutations.
|
24725405 |
2014 |
Pancreatic carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Having pancreatic cancer with tumoral loss of ATM and normal TP53 protein expression is associated with a poorer prognosis.
|
24486587 |
2014 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Together, our data support the critical role of autophagy in pancreatic cancer and show that inhibition of autophagy may have clinical utility in the treatment of these cancers, independent of p53 status.
|
24875860 |
2014 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Studies of the molecular pathology of pancreatic cancer have revealed that activation of KRAS, overexpression of cyclooxygenase-2, inactivation of p16(INK4A) and loss of p53 activities occurred in pancreatic cancer.
|
25152585 |
2014 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advanced pancreatic cancer: a translational subgroup analysis from AIO-PK0104.
|
25164437 |
2014 |
Pancreatic carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
To investigate whether simultaneous depletion of both p53 and TAp63 can recapitulate the effect of mutant p53 expression in vivo, we used a mouse model of pancreatic cancer in which the expression of mutant p53 resulted in the rapid appearance of primary tumours and metastases.
|
23873029 |
2014 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mutations in KRAS and p53 can be detected using genomic DNA from exosomes derived from pancreatic cancer cell lines and serum from patients with pancreatic cancer.
|
24398677 |
2014 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
DATS induces apoptosis of pancreatic cancer cells (Capan-2) and non-tumorigenic pancreatic ductal epithelial cells (H6C7).
|
24415872 |
2014 |
Pancreatic carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Therapeutic targets of interest include mutated molecules that predispose to pancreatic cancer such as KRAS and TP53.
|
23436799 |
2013 |