|
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Use of the comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines.
|
12492368 |
2003 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mutational pattern of p53 in pancreatic cancer is similar to bladder cancer, another smoking-related cancer, but not to lung cancer.
|
10217065 |
1999 |
|
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Various human p53 mutants (V143A, V173L, H179Q, N247I and R273H) were introduced to the TCC-SUP bladder carcinoma cell line to establish stable transfectants.
|
11435891 |
2001 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with stage T2 or T3a and p53 positive bladder cancer should be considered for early aggressive treatment options.
|
10606186 |
1999 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The data of this study show that Y chromosome losses are frequent in urothelial bladder cancer of all grades and stages, which could imply that loss of the Y chromosome is an early event in bladder cancer development. p53 mediated genomic instability is evidently not required for the development of Y chromosome losses.
|
20438408 |
2010 |
|
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There appeared to be no consistent mutation sites in exons 4 to 11 of the p53 gene and no specific patterns of the mutation in bladder cancer.
|
1540947 |
1992 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
We suggest Survivin, both as a biomarker associated to G3 BCs but negatively related to TP53 mutational status, and as a potential novel therapeutic target.
|
30650148 |
2019 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The relationship between p53 status and anticancer drugs-induced apoptosis in nine human bladder cancer cell lines.
|
10769679 |
2000 |
|
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MDM2 SNP309 promoter polymorphism and p53 mutations in urinary bladder carcinoma stage T1.
|
23356517 |
2013 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression of galectin-7 was analyzed in five bladder cancer cell lines with different p53 status after treatment with CDDP.
|
17283157 |
2007 |
|
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results of our study provide evidence for a prognostic value of p53 expression and apoptotic index with respect to the radiation response in bladder cancer in addition to more conventional prognosticators.
|
11286838 |
2001 |
|
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Frequent p53 mutations and occasional loss of chromosome 4 in invasive bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in B6D2F1 mice.
|
9473773 |
1998 |
|
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since conflicting data have been reported, further evaluation of the impact of p53 overexpression in patients treated with Bacillus Calmette-Guerin intravesical therapy for bladder carcinoma is required.
|
12503212 |
2002 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the effects of the expression of Bcl-2 protein in bladder cancer on the apoptosis induced by cisplatin or adenoviral-mediated p53 gene (Ad5CMV-p53) transfer, we transfected the bcl-2 gene into KoTCC-1, a human bladder cancer cell line that does not express the Bcl-2 protein.
|
9484785 |
1998 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
GADD45a Mediated Cell Cycle Inhibition Is Regulated By P53 In Bladder Cancer.
|
31571910 |
2019 |
|
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When we dichotomized our study population at the median age of study subjects (61 years old), low p53 expression was associated with a significantly increased BC risk in older people (OR = 2.27, 95% CI = 1.00-5.16).
|
15905204 |
2005 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic and immunophenotype analyses of TP53 in bladder cancer: TP53 alterations are associated with tumor progression.
|
15538112 |
2004 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we examined the cytolytic effect and replication of E1B-55 kD-deleted adenovirus, designated Ad5WS1, on human bladder cancer cell lines with various p53 status.
|
12778082 |
2003 |
|
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparison of P53 protein overexpression with P53 mutation in bladder cancer: clinical and biologic aspects.
|
8558845 |
1995 |
|
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that p53 nuclear overexpression is an early event in bladder cancer, occurring in 48% of cases of carcinoma in situ of the bladder.
|
8015077 |
1994 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Relevant articles improved the understanding on p53 pathways and their potential as candidate to targeted therapy in bladder cancer.
|
28281901 |
2017 |
|
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that altered repair and detoxification due to genetic polymorphism may influence the occurrence of p53 mutations in bladder cancer.
|
16343742 |
2006 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
To better define cytogenetic mechanisms of CDKN2 loss at 9p21 and of DBCCR1 loss at 9q33 in bladder cancer, and to determine correlation with p53 and pRb.
|
11410506 |
2001 |
|
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The minor allele (Trp/Gln) carriers of the p53 codon 248 demonstrated a 1.7-fold risk for BC.
|
22101376 |
2011 |
|
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, on individual SNP analysis only individuals with the p53 intron 3 16-bp duplication polymorphism variant allele had a significantly reduced bladder cancer risk (odds ratio [OR] = 0.74, 95% confidence interval [CI], 0.56-0.96).
|
18361427 |
2008 |