TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Disease: High grade serous carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3839280
Disease: High grade serous carcinoma
High grade serous carcinoma 		0.100 GeneticVariation disease BEFREE We demonstrate that targeted NGS can identify genetic alterations in minute lesions, such as TICs, and confirm TP53 mutations as early driving events for HGSC. 26181193 2015
CUI: C3839280
Disease: High grade serous carcinoma
High grade serous carcinoma 		0.100 Biomarker disease BEFREE We used integrated molecular characterization of oviductal HGSCs arising in the context of Brca1, Trp53, Rb1, and Nf1 (BPRN) inactivation to determine whether the mouse tumors recapitulate human HGSCs across multiple domains of molecular features. 31806642 2020