TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206685
Disease: Acinar Cell Carcinoma
Acinar Cell Carcinoma
0.070 GeneticVariation disease BEFREE Our findings demonstrate that breast AcCCs display TP53 and PIK3CA mutations at frequencies similar to those of common types of TNBCs, whereas these genes appear not to be altered in salivary gland AcCCs, suggesting that despite their similar histological appearances, AcCCs of the breast and salivary glands probably constitute unrelated diseases. 25688711 2015
CUI: C0206685
Disease: Acinar Cell Carcinoma
Acinar Cell Carcinoma
0.070 Biomarker disease BEFREE Acinic cell carcinoma with high-grade transformation: a report of 9 cases with immunohistochemical study and analysis of TP53 and HER-2/neu genes. 19461506 2009
CUI: C0206685
Disease: Acinar Cell Carcinoma
Acinar Cell Carcinoma
0.070 GeneticVariation disease BEFREE One example is the loss of heterozygosity at the von Hippel-Lindau (VHL) gene locus in both wild type and hereditary serous cystadenomas, and another is the virtual absence of K-ras mutation and p53 abnormalities in acinar cell carcinomas, whereas both are frequently found in ductal adenocarcinomas. 10415852 1999
CUI: C0206685
Disease: Acinar Cell Carcinoma
Acinar Cell Carcinoma
0.070 Biomarker disease BEFREE Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma. 26683340 2015
CUI: C0206685
Disease: Acinar Cell Carcinoma
Acinar Cell Carcinoma
0.070 GeneticVariation disease BEFREE TP53 was the sole highly recurrently mutated gene (75% in microglandular adenosis versus 88% in acinic cell carcinomas), and TP53 mutations were consistently coupled with loss of heterozygosity of the wild-type allele. 27713419 2017
CUI: C0206685
Disease: Acinar Cell Carcinoma
Acinar Cell Carcinoma
0.070 Biomarker disease BEFREE We examined the status of RB1, TP53, and PTEN in prostatic small cell and acinar carcinomas via immunohistochemistry (IHC), copy-number alteration analysis, and sequencing of formalin-fixed paraffin-embedded specimens. 24323898 2014
CUI: C0206685
Disease: Acinar Cell Carcinoma
Acinar Cell Carcinoma
0.070 GeneticVariation disease BEFREE Evaluation of p53 mutation in pancreatic acinar cell carcinomas of humans and transgenic mice. 9436856 1998
CUI: C0279661
Disease: Acinar cell carcinoma of pancreas
Acinar cell carcinoma of pancreas
0.020 GeneticVariation disease BEFREE TP53 alterations in pancreatic acinar cell carcinoma: new insights into the molecular pathology of this rare cancer. 26586531 2016
CUI: C0279661
Disease: Acinar cell carcinoma of pancreas
Acinar cell carcinoma of pancreas
0.020 Biomarker disease BEFREE Concurrent loss of p53 and Ink4a/Arf resembles loss of p53 alone, suggesting that Ink4a/Arf loss has no additive effect to PACC progression. 27664376 2016
CUI: C0027859
Disease: Acoustic Neuroma
Acoustic Neuroma
0.020 PosttranslationalModification disease LHGDN Our results suggest that age dependent phosphorylation of p53 protein and deregulation of p53 gene has a role in the development of human vestibular schwannomas. 16299809 2006
CUI: C0027859
Disease: Acoustic Neuroma
Acoustic Neuroma
0.020 GeneticVariation disease BEFREE The alterations of TP53 were screened by a combination of Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA) in a total of 44 vestibular schwannomas. 31049827 2019
CUI: C0027859
Disease: Acoustic Neuroma
Acoustic Neuroma
0.020 PosttranslationalModification disease BEFREE Our results suggest that age dependent phosphorylation of p53 protein and deregulation of p53 gene has a role in the development of human vestibular schwannomas. 16299809 2006
CUI: C0271907
Disease: Acquired aplastic anemia
Acquired aplastic anemia
0.020 AlteredExpression disease BEFREE We conclude that p53 overexpression in bone marrow biopsies is a valuable tool for studying bone marrow failure and may provide additional information to help differentiate hypo RA from acquired AA. 9875662 1998
CUI: C0271907
Disease: Acquired aplastic anemia
Acquired aplastic anemia
0.020 GeneticVariation disease BEFREE we investigated p53 mutation in the bone marrow and peripheral blood of forty children, FA (n = 10), acquired aplastic anemia (AAA) (n = 10), and immune thrombocytopenia (ITP) as a control (n = 20), using real-time PCR by TaqMan probe assay. 21718492 2011
CUI: C2936664
Disease: Acquired Hypogammaglobulinemia
Acquired Hypogammaglobulinemia
0.010 AlteredExpression disease BEFREE TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency. 28973009 2017
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.100 GeneticVariation group BEFREE Heterogeneous p53 mutations in a Burkitt lymphoma from an AIDS patient with monoclonal c-myc and VDJ rearrangements. 9399658 1997
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.100 Biomarker group LHGDN p53-A pro-apoptotic signal transducer involved in AIDS. 15865925 2005
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.100 Biomarker group BEFREE We analyzed the extent and cell type specificity of p53 accumulation in subcortical white matter of ten AIDS patients that had previously been shown to demonstrate white matter p53 accumulation. 18040854 2007
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.100 AlteredExpression group BEFREE Act D treatment of AIDS-KS cells markedly and selectively down-regulated Bcl-xL expression, while the expressions of decoy receptors 1 and 2, Bax, cellular FLICE (Fas-associated death domain protein-like IL-1-converting enzyme) inhibitory protein, FADD (Fas-associated death domain protein), procaspase 8, and p53 were not affected. 10228045 1999
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.100 AlteredExpression group BEFREE Several studies have shown that AIDS-SNCCL is associated with the clonal accumulation of multiple genetic lesions, including Epstein-Barr virus (EBV) infection, activation of the c-MYC and RAS oncogenes, as well as inactivation of the p53 tumor suppressor gene at variable frequencies. 8025268 1994
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.100 GeneticVariation group BEFREE In conclusion, p53 mutations occur in about 14% BIBL samples; the frequency of p53 mutations in BIBL in individuals with and without AIDS was similar. 8338955 1993
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.100 GeneticVariation group BEFREE Our findings suggest that elevated Δ133p53β is an alternative pathway to TP53 mutation in glioblastoma that aids tumor progression by promoting an immunosuppressive and chemoresistant environment. 29888503 2018
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.100 AlteredExpression group LHGDN Human immunodeficiency virus type-1 Tat/co-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription. 12501250 2003
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.100 GeneticVariation group BEFREE These lesions are not uniformly distributed, but, rather, cluster with specific types of AIDS-NHL: EBV infection is preferentially associated with LC-IBPL (4/4; 100%), while it is present in only a fraction of SNCCL (5/16; 31.2%) and LNCCL (1/4; 25%); c-myc oncogene activation clusters with SNCCL (16/16; 100%), whereas it is less frequent in LC-IBPL (1/4; 25%) and LNCCL (2/4; 50%); p53 inactivation is restricted to SNCCL (10/16; 62.5%) and consistently associated with c-myc activation. 8380252 1993
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.100 GeneticVariation group BEFREE Thus, the present study was designed to investigate the presence of HPV and p53 gene mutations in 17 formalin-fixed, paraffin-embedded KS [7 acquired immunodeficiency syndrome-KS (AIDS-KS) and 10 classic KS] specimens. 8030271 1994