|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
C/EBPβ Suppresses Keratinocyte Autonomous Type 1 IFN Response and p53 to Increase Cell Survival and Susceptibility to UVB-induced Skin Cancer.
|
30698678 |
2019 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of HIF-1α and p53 in tissues of skin cancer patients are significantly increased compared with those in skin tissues of healthy people, and the changes in their expressions are positively correlated with the vitamin B3 deficiency.
|
29064206 |
2019 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, mTOR/PI3K signaling is active in the mitosis of hyperplastic keratinocytes expressing mutant p53 and is further enhanced by stalled mitosis, indicating a potential resistance mechanism to the use of anti-mitotic drugs in the treatment of skin cancers.
|
30050055 |
2019 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
Normal sun-exposed skin contains numerous epidermal patches that stain positive for p53 protein (p53 immunopositive patches, PIPs), which are considered potential early precursors of skin cancer.
|
28844940 |
2018 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression of p53 by keratinocytes may be important in the pathogenesis of skin cancer induced by ultraviolet light.
|
29664771 |
2018 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
CTD_mouse |
Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma.
|
27923803 |
2017 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
IMQ induced p53 mRNA expression and protein accumulation, increased Ser15 phosphorylation, promoted nuclear translocation and up-regulated its target genes in skin cancer cells in a TLR7/8-independent manner.
|
26775629 |
2016 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
An early event in skin cancer is the mutation of a single p53 allele.
|
25789975 |
2015 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The wild type p53 inducible phosphatase (Wip1) plays an important role in modulating not only stress responses by various environmental stresses, but when overexpressed it also impairs the intrinsic tumor surveillance networks that are frequently found in a number of cancers including skin cancers.
|
24126074 |
2014 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Overall, no significant association between TP53 Arg72Pro polymorphism and skin cancer was observed in all genetic contrast models (Pro/Pro versus Arg/Arg, Pro/Arg versus Arg/Arg, Pro/Pro + Pro/Arg versus Arg/Arg, Pro/Pro versus Arg/Arg + Pro/Arg, Pro allele versus Arg allele).
|
24260330 |
2013 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mechanically, ATF3 activated Stat3 phosphorylation in skin cancer cell through regulation of p53 expression.
|
24460316 |
2013 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the relationship between Tp53 and cutaneous HPV infection is not well understood in skin cancers.
|
22545084 |
2012 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The MDM2 oncogene negatively regulates p53 protein levels, and both genes have functional polymorphisms that may modify skin cancer risk.
|
21123835 |
2011 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
CTD_mouse |
Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages.
|
22009531 |
2011 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Spontaneous skin cancer-like tumors were detected in about 25% of RKTG nullizygous and p53 heterozygous mice within 7 months of age.
|
21385899 |
2011 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggests that the TP53 Arg72Pro polymorphism may have little involvement in skin cancer susceptibility.
|
20861852 |
2011 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A new study shows that UV-damaged DNA is deaminated during transcription, which is a probable mechanism underlying CC tandem mutations found in the p53 gene in skin cancers.
|
20129038 |
2010 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
More recently, hydroxyurea-associated squamous dysplasia has been characterized as a premalignant precursor to hydroxyurea-associated nonmelanoma skin cancers and shown to manifest abnormal p53 expression.
|
20231502 |
2010 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pigmentary phenotypes and skin cancer risk in a nested case-control study within the Nurses' Health Study (NHS) among 219 melanoma cases, 286 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 873 controls, and among controls from other studies.
|
18814047 |
2009 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mutational spectrum of conserved regions of TP53 and PTEN genes in Kangri cancer (of the skin) in the Kashmiri population.
|
19486858 |
2009 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inactivation of the p53 tumor suppressor gene is an important event in the development of skin cancer. p53 is rapidly phosphorylated and stabilized in response to DNA damage, and the induction of apoptosis by p53 is an important mechanism by which p53 exerts its tumor-suppressive activity.
|
19064630 |
2009 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We assessed the association of the p53 codon 72 polymorphism with tanning response, and its interaction with MC1R variants on tanning response and skin cancer risk.
|
18510673 |
2008 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This hypothesis was confirmed by our finding that sunscreens used in p53 mutation inhibition experiments also protected mice against UVB-induced skin cancer.
|
18173701 |
2008 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Specifically, the analysis reveals key differences between smoking- and non-smoking-related lung cancer for TP53 mutations and the mutability of CpG sites between exons in skin cancer.
|
18296683 |
2008 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we obtained MCCs from 21 elderly patients (19 women, 2 men) and analyzed their DNA for mutation of exons of interest in several tumor-suppressor genes or oncogenes known to be frequently mutated in skin cancer: p53 (exons 4-8), Ras (exons 1 and 2), c-Kit (exon 11), and the INK4a-ARF locus (encoding p14 and p16) (exons 1 and 2).
|
18219279 |
2008 |