Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer.
|
31067569 |
2020 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Overall, the odds ratio to develop lung cancer was almost three times greater for women than for men, DNA adduct levels were higher among females than in males and mutations in the tumor suppressor gene p53 and the proto-oncogene K-RAS were more frequently found in women than in men.
|
31583690 |
2020 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Several growth related genes such as EGFR and VEGF as well as tumour suppressor genes such as p53 have been implicated in LC pathogenesis and progression.
|
31770191 |
2020 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
When generally comparing TP53 mutation group with TP53 wild-type group, we confirmed the prognostic value of poor OS of TP53 in EGFR mutant lung cancers (HR 1.73, 95% CI 1.22-2.44, P = 0.002).
|
30798634 |
2019 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Therefore, although smoking-related lung cancer unequivocally arises due to the mutagenic environment induced by tobacco carcinogens, this perspective provides a rationale for the preferential selection of lung-enriched V157, R158, and A159 mutant p53.
|
30224539 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
In conclusion, cisplatin synergistically increased the tumor-killing of CRAd by (1) increasing CRAd transduction via enhanced CAR expression and (2) increasing p53 dependent or independent apoptosis of lung cancer cell lines.
|
30841620 |
2019 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
TP53 and K-ras mutations are two of the major genetic alterations in human nonsmall cell lung cancers.
|
30873587 |
2019 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The study by Filipczak and colleagues identified the interplay between mutant p53 proteins and methylcytosine dioxygenase ten-eleven translocation 1 (TET1) in lung cancers. p53 transversion mutations were closely associated with high TET1 expression, which prevented genomic instability-associated cellular senescence.
|
30987976 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Immunomodulatory Protein from <i>Nectria haematococca</i> Induces Apoptosis in Lung Cancer Cells via the P53 Pathway.
|
31661772 |
2019 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Germ-free or antibiotic-treated mice were significantly protected from lung cancer development induced by Kras mutation and p53 loss.
|
30712876 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
SIGNIFICANCE: These studies identify TET1 as an oncogene in lung cancer whose gain of function following loss of p53 may be exploited by targeted therapy-induced senescence.<i>See related commentary by Kondo, p. 1751</i>.
|
30622117 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Irrespective of transformation, patients with EGFR/TP53/RB1-mutant lung cancers had a shorter time to discontinuation than EGFR/TP53- and EGFR-mutant -only cancers (9.5 versus 12.3 versus 36.6 months, respectively, p = 2 × 10<sup>-9</sup>).
|
31228622 |
2019 |
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
This phenotype was independent of p53 status and autophagy activity and was also observed for other cellular models, including lung cancer cells.
|
31189884 |
2019 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
It is shown that this biosensor preferentially reports on the p53 R248Q mutant in the PC9 lung cancer cell line compared with other lung cancer cell lines harbouring either wild-type or no p53.
|
30548750 |
2019 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Radioresistance of KRAS/TP53-mutated lung cancer can be overcome by radiation dose escalation or EGFR tyrosine kinase inhibition in vivo.
|
31359406 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
The WWOX/TIAF1/p53 triad-mediated cancer suppression was determined by measuring the extent of cell migration, anchorage-independent growth, SMAD promoter activation, and apoptosis. p53-deficient lung cancer cell growth in nude mice was carried out to assess the tumor suppressor function of ectopic p53 and/or WWOX.
|
31315632 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Dysfunction of p53 is a key cause of cancer development, while CCDC106 can reduce p53 stability and is associated with lung cancer.
|
30885251 |
2019 |
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Studying the effect of ICMT overexpression on tumor-associated phenotypes <i>in vitro</i> and <i>in vivo</i>, and analyzing breast and lung cancer databases, we identified a correlation between p53 status and ICMT expression in breast and lung cancers.
|
30655292 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
An oral second-generation proteasome inhibitor oprozomib significantly inhibits lung cancer in a p53 independent manner in vitro.
|
31518420 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
The efficacy of mutant K-Ras, P53 and EGFR (Epidermal Growth Factor Receptor) peptides have been tested as cancer vaccines in pancreatic, colorectal, and lung cancers.
|
31722672 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Autophagy Regulated by Gain of Function Mutant p53 Enhances Proteasomal Inhibitor-Mediated Cell Death through Induction of ROS and ERK in Lung Cancer Cells.
|
30723502 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
These results indicated that mt p53 might accelerate the recurrence of lung cancer by regulating the self-renewal kinetics of Cr-LCSCs as well as the recruitment of macrophages.
|
31781681 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
In contrast, the expression of p53‑R248Q decreased the motility and invasiveness of the breast and lung cancer cells in a p53 transactivation‑dependent manner.
|
30968154 |
2019 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Our previous study found that two novel cancer-related genes, PRR11 and SKA2, constituted a classic gene pair that was regulated by p53 and NF-Y in lung cancer.
|
30760381 |
2019 |
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Detection of p53 expression in GGN tissue may provide guidance for the diagnosis and prognosis of lung cancer.
|
30675213 |
2019 |