Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We describe a gene encoding p73, a protein that shares considerable homology with the tumor suppressor p53. p73 maps to 1p36, a region frequently deleted in neuroblastoma and other tumors and thought to contain multiple tumor suppressor genes.
|
9288759 |
1997 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data suggest that the p73 gene is not playing an essential role, but expression of p73 may associate with tumor growth in prostatic carcinogenesis.
|
9605745 |
1998 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings strongly suggest that p73 may play an important role in lung tumorigenesis through activation of a silent allele and overexpression of wild-type p73 rather than as a tumor suppressor.
|
9622072 |
1998 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results suggest that, in CRCs, p73 may not play a role as a tumor suppressor, at least not in a classic Knudson manner.
|
9664127 |
1998 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine whether p73 is a potential tumor suppressor gene involved in the development of oligodendrogliomas, we performed mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions.
|
9721206 |
1998 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In addition, LOH for p73 was found in only 2 of 25 (8%) tumors.
|
9797131 |
1998 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although most NB tumors expressed p73 within the normal tissue range, wild-type p73 expression levels varied widely in NB and non-NB tumors and NB cell lines with increases up to 90-fold compared with normal tissues.
|
9831242 |
1998 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We report the refined chromosomal localization of the putative tumor suppressor gene TP73 (alias p73) within the genomic region between the anonymous loci D1Z2 and D1S47.
|
9858816 |
1998 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We mapped p73 using radiation hybrids and localized the gene to an interval that putatively harbors a melanoma tumor suppressor locus.
|
9892203 |
1999 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Since genetic alterations at the tumour suppressor locus 1p36 have been also identified in malignant melanomas, we investigated the expression of p73 in a panel of nine different human melanoma cell lines, 17 melanocytic naevi, 17 primary malignant melanomas and 20 metastases by reverse transcriptase polymerase chain reaction (PCR) and Southern blotting.
|
9918412 |
1998 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, p73 is infrequently mutated in primary NBLs and may hardly function as a tumor suppressor in a classic Knudson's manner.
|
10023682 |
1999 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest that the p73 is unlikely to be a tumor suppressor gene, but that overexpression of p73 may contribute to tumorigenesis in bladder cancer.
|
10102633 |
1999 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Whereas the short (p73beta) isoform accounted for 20-25% of the total p73 mRNA in most of the tumors, these splicing characteristics were altered in ependymomas (only 9% of p73beta) and in neurinomas (up to 53% of p73beta).
|
10213163 |
1999 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that inactivation of the p73 gene does not play a major role in the tumour types analysed in the present study.
|
10218465 |
1999 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Quantitative PCR demonstrated that p73 expression is the same in both normal and tumor prostate tissues.
|
10221564 |
1999 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, we could find no evidence for p73 being the neuroblastoma tumor suppressor gene in 1p36.
|
10341287 |
1999 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We failed to observe a correlation between p73 expression or p53 and apoptosis within a given tumour.
|
10362118 |
1999 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Elevated expression of p73 was frequently observed in carcinoma tissues [18 (40.0%) of 45] and showed a strong correlation with tumor stage or grade.
|
10383132 |
1999 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, 38% (29 cases) of breast cancers had elevated p73 mRNA ranging from 5-25-fold above normal, with the remaining tumors (64%) falling within the normal range.
|
10397274 |
1999 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The p73 gene is a candidate tumor suppressor gene that has significant homology to p53.
|
10400412 |
1999 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data indicate that p73 does not play a role as a tumor suppressor in melanoma development.
|
10404074 |
1999 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In 87% of the cases (52/60) p73 expression in tumour was more than twice as high as that in paired normal lung tissues, and the difference between p73 expression in tumour and normal lung tissue was significant (P < 0.0001).
|
10408409 |
1999 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Because p73 encodes for a protein that is both structurally and functionally homologous to the p53 protein, p73 has been postulated to be a candidate tumor suppressor gene.
|
10416592 |
1999 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
These findings suggest that silencing of the p73 gene by hypermethylation may contribute to development and/or progression of lymphoid neoplasms.
|
10419905 |
1999 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Sequencing of the cDNA for this protein, chronic ulcerative stomatitis protein, revealed it to be homologous to the p53 tumor suppressor and to the p73 putative tumor suppressor, and to be a splicing variant of the KET gene.
|
10469295 |
1999 |