Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Homozygous CC genotype of 3111T/C, GSK3B-AT/TT genotype of rs33458 and haplotype of TPH1 218A/C were associated with insomnia symptom of MDD.
|
31111219 |
2019 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that TPH1 218A/C and HTR5A 12A/T polymorphisms cannot predict treatment response in major depression.
|
24903772 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our results suggest that TPH1 218A/C and HTR5A 12A/T polymorphisms cannot predict treatment response in major depression.
|
24903772 |
2014 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The A allele at TPH1 rs1800532 may be associated with citalopram efficacy only in melancholic and psychotic MDD.
|
23221997 |
2013 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The A allele at TPH1 rs1800532 may be associated with citalopram efficacy only in melancholic and psychotic MDD.
|
23221997 |
2013 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was an increased risk of having MDD in homozygous female carriers of the TPH1 A-allele (odds ratio: 4.35) and homozygous carriers of the MAOA VNTR low activity allele 3R (odds ratio: 3.37).
|
23157339 |
2013 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
However, the relationship between temperament and TPH1 genotype in major depression is poorly understood, as only one study has been published so far.
|
23597148 |
2013 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We detected allelic or genotypic associations of MAOA, TPH1, FKBP5 and BDNF in clinically significant MDD in AD.
|
23157339 |
2013 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, the relationship between temperament and TPH1 genotype in major depression is poorly understood, as only one study has been published so far.
|
23597148 |
2013 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to assess the association of TPH1 A218C polymorphism (rs1800532) with mood disorders, including major depressive disorder and bipolar disorder, and alcohol dependence by using meta-analysis.
|
21601290 |
2012 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In addition, TPH1 gene is most likely to have a shared effect on aggression and MDD.
|
22697203 |
2012 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, TPH1 gene is most likely to have a shared effect on aggression and MDD.
|
22697203 |
2012 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One hundred five healthy controls and 115 outpatients diagnosed with MDD were recruited and genotyped for the TPH1 218A/C (rs1800532) polymorphism.
|
20945066 |
2011 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TPH1 218A/C polymorphism was associated with the risk of MDD.
|
19874868 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the A218C polymorphism of the TPH1 gene serves as a modulator of amygdala activity in patients with MDD.
|
19500158 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The homozygous recessive genotype of the TPH A218C polymorphism has a significant effect on risk for bipolar disorder but not major depressive disorder.
|
19032713 |
2008 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined the association between a polymorphism in intron 7 of TPH1, 218A>C and plasma total TRP levels in 118 patients with major depression.
|
18177948 |
2008 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was no association between TPH-2 gene variants and MD in the same population that had shown a strong association with TPH-1.
|
17692928 |
2008 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The remission rate to citalopram treatment was worse in MDD subjects with the TPH1 A/A and A/C genotypes than in those with the TPH1 C/C genotype.
|
16979275 |
2007 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The result suggests that 218A/C variants of TPH1 cannot play a major role as predictor of treatment response as well as intolerance in Japanese patients with major depression.
|
18332644 |
2007 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interaction between TPH1 and GNB3 genotypes and electroconvulsive therapy in major depression.
|
17066254 |
2007 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tryptophan hydroxylase-1 association with MD is still debated.
|
16165107 |
2006 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results suggest that the A218C polymorphism of the TPH gene does not play a major role in pathogenesis in MDD and does not serve as a modulator of antidepressant activity.
|
16314762 |
2005 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined whether polymorphism of the TPH1 gene is related to the etiology of major depression, anxiety and comorbid depression and anxiety.
|
15544576 |
2004 |