|
Behcet Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The transmembrane immunoglobulin and mucin domain-3 (TIM-3) is a distinct member of the TIM family that is preferentially expressed on Th1 cells and plays a role in Th1-mediated autoimmune or inflammatory diseases, such as Behçet disease.
|
31644615 |
2019 |
|
Encephalomyelitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study was conducted to examine the pathological changes and B cell subsets in experimental autoimmune encephalomyelitis (EAE) mice, and analyze the expression of triosephosphate isomerase (TPI) and GADPH to define the role of B cell subsets in the disease.
|
31286875 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Defective Treg response in acute kidney injury was caused by a reduction in TIM-3<sup>+</sup> Treg cells.
|
29985717 |
2019 |
|
Pleurisy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The cutoffs of intratumor T-regulatory (>1.1%) cells, M2-macrophages (>36%), granulocytic and monocytic myeloid-derived suppressor cells (MDSC; >5.1% and 4.2%, respectively), CD4 molecule-positive (CD4<sup>+</sup>) programmed death 1-positive (PD-1<sup>+</sup>) (>5.2%) and CD8<sup>+</sup>PD-1<sup>+</sup> (6.4%) cells, CD4<sup>+</sup> lymphocyte activating 3-positive (LAG-3<sup>+</sup>) (>2.8% ) and CD8<sup>+</sup>LAG-3<sup>+</sup> (>2.8%) cells, CD4<sup>+</sup> T cell immunoglobulin and mucin domain 3-positive (TIM-3<sup>+</sup>) (>2.5%), and CD8<sup>+</sup>TIM-3<sup>+</sup> (>2.6%) cells discriminated MPM from pleuritis with 100% sensitivity and 89% specificity.
|
31078776 |
2019 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Mutations in the gene triosephosphate isomerase (TPI) lead to a severe multisystem condition that is characterized by hemolytic anemia, a weakened immune system, and significant neurologic symptoms such as seizures, distal neuropathy, and intellectual disability.No effective therapy is available.
|
31075491 |
2019 |
|
Progressive supranuclear palsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
To assess the safety, tolerability, and pharmacodynamics of the microtubule stabilizer TPI-287 (abeotaxane) in Alzheimer disease (AD) or the 4-repeat tauopathies (4RT) progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS).
|
31710340 |
2019 |
|
Toxoplasmosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
TPI is a novel antigen with potential for the serological diagnosis of toxoplasmosis, and composite recombinant proteins (TPI, GRA2, and GRA7) have great sera diagnostic value for the detection of the disorder.
|
31279928 |
2019 |
|
Malnutrition
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Moreover, human TPI, mutations in which cause a glycolytic deficiency syndrome, also forms aggregates in response to cadmium treatment, suggesting that this conserved enzyme is folding-labile and may be a useful endogenous model for investigating thiol-specific proteotoxicity.
|
30601716 |
2019 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Distinct prognostic value of circulating anti-telomerase CD4<sup>+</sup> Th1 immunity and exhausted PD-1<sup>+</sup>/TIM-3<sup>+</sup> T cells in lung cancer.
|
31358938 |
2019 |
|
Coinfection
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Multilocus genotyping by PCR/sequencing of beta-giardin (bg), triose phosphate isomerase (tpi), and glutamate dehydrogenase (gdh) genes of representative number of positive samples (65) revealed that assemblages A, B and mixed infections (A + B) occurred in 26/65 (40.0%), 32/65 (49.2%) and 10.8% (7/65) of the analyzed isolates, respectively.
|
31100269 |
2019 |
|
Hemorrhagic Fever, Ebola
|
0.010 |
Biomarker
|
disease |
BEFREE |
Biomechanical characterization of TIM protein-mediated Ebola virus-host cell adhesion.
|
30670766 |
2019 |
|
Neuropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
Mutations in the gene triosephosphate isomerase (TPI) lead to a severe multisystem condition that is characterized by hemolytic anemia, a weakened immune system, and significant neurologic symptoms such as seizures, distal neuropathy, and intellectual disability.No effective therapy is available.
|
31075491 |
2019 |
|
Progressive Neoplastic Disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Notably, combination of TC PD-L1 expression with % CD8<sup>+</sup>PD-1<sup>+</sup>TIM-3<sup>-</sup>LAG-3<sup>-</sup> TIC identified three groups of patients for which irPFS and irORR were significantly different.
|
30670497 |
2019 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Distinct prognostic value of circulating anti-telomerase CD4<sup>+</sup> Th1 immunity and exhausted PD-1<sup>+</sup>/TIM-3<sup>+</sup> T cells in lung cancer.
|
31358938 |
2019 |
|
Hypoxic-Ischemic Encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The work presented here investigates the agreement between metabolic ratios reported from vendor-provided and LCModel fitting algorithms using MRS data obtained on Siemens 3 T TIM Trio and 3 T Skyra MRI scanners in a total of 55 premature infants and term neonates with hypoxic ischemic encephalopathy (HIE).
|
30924565 |
2019 |
|
Malignant Pleural Mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The cutoffs of intratumor T-regulatory (>1.1%) cells, M2-macrophages (>36%), granulocytic and monocytic myeloid-derived suppressor cells (MDSC; >5.1% and 4.2%, respectively), CD4 molecule-positive (CD4<sup>+</sup>) programmed death 1-positive (PD-1<sup>+</sup>) (>5.2%) and CD8<sup>+</sup>PD-1<sup>+</sup> (6.4%) cells, CD4<sup>+</sup> lymphocyte activating 3-positive (LAG-3<sup>+</sup>) (>2.8% ) and CD8<sup>+</sup>LAG-3<sup>+</sup> (>2.8%) cells, CD4<sup>+</sup> T cell immunoglobulin and mucin domain 3-positive (TIM-3<sup>+</sup>) (>2.5%), and CD8<sup>+</sup>TIM-3<sup>+</sup> (>2.6%) cells discriminated MPM from pleuritis with 100% sensitivity and 89% specificity.
|
31078776 |
2019 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Distinct prognostic value of circulating anti-telomerase CD4<sup>+</sup> Th1 immunity and exhausted PD-1<sup>+</sup>/TIM-3<sup>+</sup> T cells in lung cancer.
|
31358938 |
2019 |
|
Protein Misfolding Disorders
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Some aspects indicate the disease could be caused by insufficient enzyme activity, whereas other observations indicate it could be a protein misfolding disease with tissue-specific differences in TPI activity.
|
31111503 |
2019 |
|
Progressive cGVHD
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, combination of TC PD-L1 expression with % CD8<sup>+</sup>PD-1<sup>+</sup>TIM-3<sup>-</sup>LAG-3<sup>-</sup> TIC identified three groups of patients for which irPFS and irORR were significantly different.
|
30670497 |
2019 |
|
Intellectual Disability
|
0.010 |
Biomarker
|
group |
BEFREE |
Mutations in the gene triosephosphate isomerase (TPI) lead to a severe multisystem condition that is characterized by hemolytic anemia, a weakened immune system, and significant neurologic symptoms such as seizures, distal neuropathy, and intellectual disability.No effective therapy is available.
|
31075491 |
2019 |
|
Advanced Bile Duct Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Trifluridine/tipiracil (FTD/TPI) has activity in both fluoropyrimidine-sensitive and -resistant tumors, which led us to conduct a single arm phase II trial to evaluate the safety and efficacy of FTD/TPI for patients previously treated for advanced BTC.
|
31826977 |
2019 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E-KO mice fed a high-fat diet for 6 weeks before treatment with RMT1-10 also increased TIM-1<sup>+</sup>IgM<sup>+</sup>IL-10<sup>+</sup> and TIM-1<sup>+</sup>IgM<sup>+</sup>IL-10<sup>-</sup> B1a cells and IgM levels and attenuated progression of established atherosclerosis.
|
29936416 |
2018 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E-KO mice fed a high-fat diet for 6 weeks before treatment with RMT1-10 also increased TIM-1<sup>+</sup>IgM<sup>+</sup>IL-10<sup>+</sup> and TIM-1<sup>+</sup>IgM<sup>+</sup>IL-10<sup>-</sup> B1a cells and IgM levels and attenuated progression of established atherosclerosis.
|
29936416 |
2018 |
|
Dengue Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
TIM-1 Ubiquitination Mediates Dengue Virus Entry.
|
29742433 |
2018 |
|
Diarrhea
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This retrospective cohort study was performed to analyze and compare the TPI protein-positive rates in outpatients and hospitalized patients with and without diarrhea (control group).
|
30392450 |
2018 |