|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
In this post hoc analysis of cross-sectional data from US participants in the Comparison of AMD Treatments Trials, genotyping was performed in 835 participants with TaqMan assays for the SNPs rs1061170 (Y402H variant in CFH), rs800292 (rs800292" genes_norm="3075">I62V variant in CFH), rs10490924 (rs10490924;s10490924" genes_norm="387715;717">A69S variant in ARMS2), rs11200638 (HTRA1), rs547154 (C2), rs2230199 (rs2230199" genes_norm="5654;718">R102G variant in C3), rs10468017 (LIPC), and rs4151667 (L9H variant in CFB).
|
29801032 |
2018 |
|
Age related macular degeneration
|
0.680 |
Biomarker
|
disease |
BEFREE |
To evaluate the contribution of genetic variants of complement factor H (CFH), complement component 2 and 3 (C2 and C3), complement factor B (CFB), and age-related maculopathy susceptibility 2 (ARMS2) to age-related macular degeneration (AMD) risk in the Mexican Mestizo population.
|
24453474 |
2014 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
GWASDB |
Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.
|
23577725 |
2013 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
GWASDB |
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.
|
22705344 |
2012 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
To determine whether genetic variants in the complement component 2 and factor B gene (C2/CFB) locus are associated with the risk for typical age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV) in a Japanese population.
|
22232432 |
2012 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.
|
22694956 |
2012 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
GWASCAT |
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|
21665990 |
2011 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
GWASDB |
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|
21665990 |
2011 |
|
Age related macular degeneration
|
0.680 |
Biomarker
|
disease |
BEFREE |
The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration.
|
19696172 |
2010 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
GWASDB |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
GWASCAT |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
No association with AMD was found for SNP rs9332739 (E318D) in the C2 gene or for rs4151667 (L9H), rs1048709 (R150R), rs4151659 (K565E), or rs2072633 (IVS17) in the BF gene.
|
18806293 |
2009 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration.
|
18806297 |
2009 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
LHGDN |
Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration.
|
18806297 |
2009 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs in CC2 and CFB were strongly associated with decreased risk of AMD in the case-control data set (CC2 E318D: P = 0.02; CC2 rs547154: P = 9 x 10(-6); and CFB R32Q P = 2 x 10(-5)).
|
17576744 |
2007 |
|
Age related macular degeneration
|
0.680 |
Biomarker
|
disease |
LHGDN |
Three SNPs in CC2 and CFB were strongly associated with decreased risk of AMD in the case-control data set (CC2 E318D: P = 0.02; CC2 rs547154: P = 9 x 10(-6); and CFB R32Q P = 2 x 10(-5)).
|
17576744 |
2007 |
|
Age related macular degeneration
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
We screened factor B (BF) and complement component 2 (C2) genes, located in the major histocompatibility complex class III region, for genetic variation in two independent cohorts comprising approximately 900 individuals with AMD and approximately 400 matched controls.
|
16518403 |
2006 |
|
Age related macular degeneration
|
0.680 |
Biomarker
|
disease |
CTD_human |
We screened factor B (BF) and complement component 2 (C2) genes, located in the major histocompatibility complex class III region, for genetic variation in two independent cohorts comprising approximately 900 individuals with AMD and approximately 400 matched controls.
|
16518403 |
2006 |
|
Age related macular degeneration
|
0.680 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|