Hypothyroidism
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
05 to 2.89), female gender (odds ratio, 2.02; 95 % confidence interval, 1.05 to 3.87), and positive thyroid peroxidase antibody (odds ratio, 4.99; 95 % confidence interval, 2.83 to 8.79) were associated with higher odds of hypothyroidism among type 2 diabetes mellitus inpatients.
|
27605039 |
2017 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Hypothyroid PPT patients were more often thyroid autoantibody-positive (P<0.005) and the TPO antibody median value was higher compared to hyperthyroid PPT patients (500 and 32 U/ml, P<0.0001).
|
20408864 |
2010 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thyroid peroxidase (TPO) defects, typically transmitted as autosomal recessive traits, result in hypothyroid goiters with failure to convert iodide into organic iodine.
|
12938097 |
2003 |
Hypothyroidism
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
TPO and thyroglobulin antibody levels at baseline may be predictive of hypothyroidism.
|
28882978 |
2018 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A truncating TPO mutation (Y55X) in patients with hypothyroidism and total iodide organification defect.
|
25328990 |
2015 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
After the 5-yr follow-up, an additional 11 (16%) developed hypothyroidism, of whom four (36%) had elevated thyroid peroxidase.
|
15623818 |
2005 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
By multivariate analysis, background thyroiditis (relative risk [RR], 9.78; p = 0.004), thyroid peroxidase antibody positivity (RR, 9.90; p = 0.003), nodule size (RR, 1.24; p < 0.001), and initial TSH (RR, 1.47; p = 0.009) were the independent risk factors for predicting hypothyroidism in euthyroid patients.
|
29529842 |
2019 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Congenital goitre and hypothyroidism with impaired iodide organification and high thyroid peroxidase concentration.
|
487612 |
1979 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Criteria for early diagnosis of hypothyroidism (i.e., sensitivity of 94% and specificity of 82%, p < 0.0001) were obtained based on baseline and three-year follow-ups of thyroid function tests and thyroid peroxidase antibody.
|
28071990 |
2017 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Determination of anti-TPO antibody levels and exon 12 TPO gene polymorphisms in patients with SCH can be helpful for prediction of overt hypothyroidism.
|
28500830 |
2017 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Finally, TPO autoantibody epitopic fingerprints are distinctive for individual sera, are not associated with hypothyroidism, but are conserved over time (indicating a lack of B cell epitope spreading).
|
7544244 |
1995 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Five anti-TPO-positive celiac patients were hypothyroid (two overt, three subclinical).
|
9647032 |
1998 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
|
30367059 |
2018 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Hashimoto's thyroiditis was also diagnosed because she had a diffuse goiter and a mild hypothyroidism (TSH 8.20 μU/mL, and FT4 0.80 ng/mL) with positive autoantibodies for thyroid peroxidase and thyroglobulin.
|
29459556 |
2018 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Homozygotes for the mutant TSHR and a compound heterozygote for the TPO mutations presented frank hypothyroidism.
|
21490078 |
2011 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, the subset of hypothyroidism single-nucleotide polymorphisms involved in autoimmunity and thyroid peroxidase antibodies levels were not associated with AF.
|
30673084 |
2019 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Hyperthyroidism in Graves' disease is caused by thyroid-stimulating autoantibodies to the TSH receptor (TSHR), whereas hypothyroidism in Hashimoto's thyroiditis is associated with thyroid peroxidase and thyroglobulin autoantibodies.
|
17823263 |
2007 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
In patients who have circulating thyroid peroxidase antibodies, there is a greater risk of progression from subclinical to overt hypothyroidism.
|
31287527 |
2019 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, a dual effect polymeric system was designed to release Cepharanthine (CEP) to block T cell activation and Selenium (Se) to decrease the anti-thyroid peroxidase (TPOAb) concentration in order to treat hypothyroidism.
|
31788940 |
2020 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Isolated hypothyroidism was rare (n=2) and late (median: 30 weeks).Three patients had anti-TPO antibodies.
|
31005502 |
2019 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
It is characterized as both cellular immune responses with T, B cells infiltrating to the thyroid gland followed by hypothyroidism as a result of destruction of the thyroid follicles and fibrous replacement of the parenchymal tissue, as well as immune response for TPO and Tg-antibody production.
|
30093941 |
2018 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Nivolumab-induced immune thrombocytopenia and hypothyroidism were suspected based on the presence of platelet-associated IgG, an increased level of autoantibodies to thyroglobulin and thyroid peroxidase and an enlarged thyroid gland.
|
29260625 |
2018 |