|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thyroid peroxidase antibody may be associated with the cardiovascular risk of patients with Graves' disease through its effect on homocysteine.
|
29966154 |
2020 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoimmunity to TPO is characterised by autoantibodies and T cell reactivity in Hashimoto's disease and Graves' disease.
|
30742860 |
2019 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
TPO-Ab and TRAb tests are used to diagnose Hashimoto's thyroiditis and Graves' disease, respectively.
|
30215224 |
2019 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antibodies to thyroid peroxidase (TPO), the enzyme that catalyses thyroid-hormone production and antibodies to the receptor for the thyroid-stimulating hormone, are characteristic of HT and GD, respectively.
|
30208979 |
2019 |
|
Graves Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TFT (Free T4=101 pmol/L, thyroid-stimulating hormone <0.05 mIU/L) with raised thyroid peroxidase antibody levels (TPO=541 IU/mL) confirmed autoimmune hyperthyroidism.
|
29574428 |
2018 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated thyroid hormones and suppressed TSH levels with elevated thyroperoxidase antibodies and thyroid stimulating immunoglobulins confirmed the diagnosis of Graves' disease.
|
30226207 |
2018 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, TPO rs2071400 and rs2071403 polymorphisms were associated with the development of HD and GD, but not with the prognosis.
|
28845025 |
2017 |
|
Graves Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, there was a significant correlation between the TRAF-6 mRNA and TPO Ab levels in the eGD group and between the TRAF-6 mRNA and TR Ab levels in the NC group.
|
28219358 |
2017 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of our study further suggest that rs11675434 SNP located near TPO is associated with the development of GO, especially in males and patients with later age of GD onset.
|
27829681 |
2017 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although rs11675434 located near TPO showed no association with GD susceptibility, it was significantly associated with the presence of clinically evident Graves' ophthalmopathy (GO, P = 5·2 × 10(-5) , OR = 1·64), and this effect was independent from smoking status, age of GD onset and gender.
|
25345847 |
2015 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease).
|
24586183 |
2014 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although there is not association between ICAM1 (G241R and K469E), VCAM1 (T-1591C and T-833C), and E-selectin (S128R) SNPs and susceptibility to GD, higher anti-TPO in E-selectin 128 SR + RR, and lower TSH in ICAM1 469 KE + EE subjects suspect that these genotypes are prone to increased antithyroid autoantibody production with more accentuated TSH suppression in GD.
|
23242661 |
2013 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We measured two anti-islet autoantibodies, glutamate decarboxylase (GADA, n = 2,506), insulinoma-associated antigen 2 (IA-2A, n = 2,498), antibodies to the autoimmune thyroid (Graves') disease (AITD) autoantigen thyroid peroxidase (TPOA, n = 8,300), and antibodies against gastric parietal cells (PCA, n = 4,328) that are associated with autoimmune gastritis.
|
21829393 |
2011 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Subset analysis of patients with persistently elevated thyroid peroxidase (TPO) and/or thyroglobulin (Tg) antibodies (Abs), (TPO/Tg Abs), after treatment (n=126), revealed a significantly stronger association of the SNP with disease (P=5.2 x 10(-5), OR=2.5) than in GD patients who were thyroid antibody-negative.
|
17344890 |
2007 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hyperthyroidism in Graves' disease is caused by thyroid-stimulating autoantibodies to the TSH receptor (TSHR), whereas hypothyroidism in Hashimoto's thyroiditis is associated with thyroid peroxidase and thyroglobulin autoantibodies.
|
17823263 |
2007 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously reported that the absence of thyroid peroxidase antibodies (TPOAb) in Graves' disease (GD) was associated with an increased risk of Graves' ophthalmopathy (GO).
|
16868133 |
2006 |
|
Graves Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The lowest CXCR6 mRNA levels were obtained from thyroid nodules from TA patients and GD patients with low thyroid peroxidase autoantibody levels.
|
15817921 |
2005 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
An association between Graves' disease (GD) and chronic hepatitis C (C-HC) has been observed both in the presence and the absence of recombinant interferon-alpha (rIFN-alpha) treatment. rIFN-alpha-induced GD is characterized by suppressed thyroid-stimulating hormone levels; normal or elevated free triiodothyronine (FT3) and free thyroxine (FT4) values; the presence of thyroid peroxidase antibodies, antithyroglobulin antibodies, and thyroid receptor antibodies; and high iodine thyroid uptake.
|
16025878 |
2005 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum TPO antibody (TPO-Ab, 67.3+/-11.6%) and Tg antibody (Tg-Ab, 59.8+/-10.1%) in HT were higher than those in GD (28.4+/-5.7%, 23.1+/-4.9%) and TFA (6.1+/-3.4%, 7.2 +/-4.6%) (p<0.01).
|
16285898 |
2004 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
TPO transcripts were detected in 7/10 (70%) patients with known metastases of thyroid cancer and in 39 of 110 (36%) patients without metastases (P<0.05), in 15/44 (34%) patients with goitre, in 17/41 (41%) cases with GD and in 4/54 (7.4%) subjects in the control group (P<0.05, controls vs all patients with thyroid disease).
|
12459031 |
2002 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It was established that approximately 20% of the TPO purified from a Graves' disease thyroid gland was precipitated by polyclonal antibodies directed against a specific part of the cytoplasmic tail of TPOzanelli.
|
11327880 |
2001 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have shown that thyroid epithelial cells (TEC), the only cells that produce TPO, express HLA class II molecules in Graves' disease and can act as an antigen-presenting cells, presenting TPO after endogenous processing to autoantigen-reactive T cell clones.
|
8627148 |
1996 |
|
Graves Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Autologous EBV-transformed B cell lines (EBVL) from a patient with Graves' disease (GD) were transfected with the expression vector pREP4 encoding thyroid peroxidase (TPO), the thyroid-stimulating hormone receptor (TSHR), or chloramphenicol acetyl transferase.The relevant proteins were expressed.
|
8189073 |
1994 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
A cloned 3.088 kb cDNA coding for the entire mature human TPO was isolated from a cDNA library derived from a pathological thyroid gland of a Graves' disease patient and used further to generate a so-called TPO epitope cDNA library in order to map linear autoantigenic epitopes involving a recombinant molecular biology approach.
|
1379223 |
1992 |
|
Graves Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Incubation of thyroid cells with TSH receptor autoantibodies from different Graves' disease patients for 48 h led to time- and dose-dependent increases in the levels of thyroid peroxidase and thyroglobulin mRNA in primary cultures of thyrocytes.
|
1914236 |
1991 |