TPO, thyroid peroxidase, 7173

N. diseases: 306; N. variants: 47
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 Biomarker disease BEFREE Thyroid abnormalities were detected in 45 (52.3%) patients, including 28 (32.3%) hypothyroidism, 3 (3.5%) hyperthyroidism and 20 (23.3%) thyroperoxidase antibody positivity. 31780218 2019
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 AlteredExpression disease BEFREE In conclusion, the presence of DIO2 peptide antibodies is connected to Graves' hyperthyroidism influencing the levels of antibodies against TPO, Tg and TSH receptor, as well as the therapeutic efficacy of antithyroid drugs. 30610492 2019
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 AlteredExpression disease BEFREE Genomewide significant variants were used as instruments for standardized FT4 and thyrotropin levels within the reference range, standardized triiodothyronine (FT3):FT4 ratio, hypothyroidism, standardized thyroid peroxidase antibody levels, and hyperthyroidism. 30673084 2019
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 Biomarker disease BEFREE We reviewed administrative data on 174011 patients with TSH measured at a tertiary referral center between 2011 and 2017 to identify individuals with hyperthyroidism (TSH <0.05 mU/L) and their subsequent outcomes: evaluation (measurement of T4, T3, radioactive iodine (RAI) uptake scan, thyroid-stimulating immunoglobulin, thyroid peroxidase antibodies) diagnosis, referral and treatment. 30004926 2018
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 Biomarker disease BEFREE Our meta-analysis suggests that TPO-Ab positivity, hypothyroidism and hyperthyroidism might be associated with prevalent psoriatic disease. 28747386 2017
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 AlteredExpression disease BEFREE Blood examinations showed hyperthyroidism (thyroid-stimulating hormone ≤.010 µU/mL; free T3 ≥25.0 pg/mL; free T4 ≥8.0 ng/dL) and elevation of antithyroid antibody levels (thyroid peroxidase antibody, 87 IU/mL). 27919794 2017
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 AlteredExpression disease BEFREE Graves' ophthalmopathy is characterized by hyperthyroidism, which is associated with higher serum T<sub>3</sub> levels than T<sub>4</sub> due to deiodinase enzymes.The effect of Graves' patient's sera (n=52) with elevated thyroid hormone and TSH receptor or thyroid peroxidase antibody (anti-TPO) levels was investigated on thyroidal, skeletal and eye muscle type 2 deiodinase enzyme (DII) activities. 28750432 2017
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 Biomarker disease BEFREE This case illustrates the necessity to analyse patients with hyperthyroidism accompanied by diffuse (99 m)Tc uptake and negative TPO, TSHR, and thyroglobulin antibodies for TSHR germline mutations. 22763653 2012
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 Biomarker disease BEFREE The prevalence of thyroid peroxidase-Ab was higher in both hypothyroid and hyperthyroid cases than in controls. 20956436 2011
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 Biomarker disease BEFREE Hypothyroid PPT patients were more often thyroid autoantibody-positive (P<0.005) and the TPO antibody median value was higher compared to hyperthyroid PPT patients (500 and 32 U/ml, P<0.0001). 20408864 2010
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 Biomarker disease BEFREE Hyperthyroidism in Graves' disease is caused by thyroid-stimulating autoantibodies to the TSH receptor (TSHR), whereas hypothyroidism in Hashimoto's thyroiditis is associated with thyroid peroxidase and thyroglobulin autoantibodies. 17823263 2007
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 GeneticVariation disease BEFREE Post partum thyroiditis occurs in 50% of TPO AB+ve women and is characterised by transient hyperthyroidism followed by transient hypothyroidism during the first six months, post partum. 12389641 2002
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.100 Biomarker disease BEFREE There was no correlation between reactivity to D1 and either clinical measures of hyperthyroidism or antibody titers to thyroid peroxidase or thyroglobulin. 8345048 1993