TPO, thyroid peroxidase, 7173

N. diseases: 306; N. variants: 47
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 GeneticVariation disease BEFREE TPO genetic variants may be associated with thyroid carcinoma and hypoechoic thyroid nodules in a few cases. 26406404 2015
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE Mutations in the TPO gene are common in congenital hypothyroidism, and there are also signs of the implication of TPO in thyroid cancer. 23754668 2013
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE The cotransduction of TTF-1 and Pax-8 gene, with resulting NIS-mediated radioiodine accumulation and TPO and Tg-mediated radioiodine organification and intracellular retention, may lead to effective radioiodine therapy of thyroid carcinoma. 22498723 2012
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 AlteredExpression disease BEFREE These results indicate that Pax-8 can promote iodide uptake, and specifically prolong the retention time of iodide in thyroid cancer in vitro and in vivo by promoting the expression of TPO and Tg proteins. 21833035 2012
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 GeneticVariation disease BEFREE The occurrence of thyroid carcinoma in patients with congenital hypothyroidism (CH) caused by dyshormonogenesis is very rare, and has only been reported in one patient harboring mutations in the thyroid peroxidase (TPO) gene. 22435912 2012
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 GeneticVariation disease BEFREE BRAF(V600E) mutation, in both primary and metastatic thyroid cancers, is associated with a marked drop in thyroperoxidase (29-fold) and pendrin (20-fold) expression and a considerable increase (five-fold) in GLUT-1 expression. 17854396 2008
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 AlteredExpression disease BEFREE These results confirmed the decrease of TPO expression in 97% of thyroid carcinomas regardless of histological type and the overexpression of shorter splice variants in follicular tumors. 16728576 2006
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 GeneticVariation disease BEFREE As individuals with goitrous hypothyroidism caused by TPO gene mutation develop thyroid cancer, regular and careful follow-up for such patients must be done. 16284446 2005
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE Natural flavonoids (plant pigments) have been shown to inhibit thyroid peroxidase (TPO) in vitro and the growth of thyroid cancer cell lines. 15080787 2004
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE Qualitative analysis of baseline and stimulated TG, NIS and PDS mRNA showed high sensitivity but low specificity in the prediction of thyroid cancer recurrence or metastases (accuracy under THST = 51%, 43% and 54%, respectively), whereas TPO and TSHR mRNA assays had higher specificity but low sensitivity, with accuracy under THST of 67% and 61%, respectively, that improved when these tests were combined. 15170676 2004
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE Iodination of proteins in TPO transfected thyroid cancer cells is independent of NIS. 15062578 2003
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE TPO transcripts were detected in 7/10 (70%) patients with known metastases of thyroid cancer and in 39 of 110 (36%) patients without metastases (P<0.05), in 15/44 (34%) patients with goitre, in 17/41 (41%) cases with GD and in 4/54 (7.4%) subjects in the control group (P<0.05, controls vs all patients with thyroid disease). 12459031 2002
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 AlteredExpression disease BEFREE These results confirm that TPO is expressed in thyroid carcinomas but in smaller amounts than in normal tissue and benign tumors. 10718546 2000
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 AlteredExpression disease BEFREE TPO expression was decreased in thyroid carcinomas, but was normal in cold adenomas; it was increased in toxic adenomas and Graves' thyroid tissues Tg expression was decreased in thyroid carcinomas, but was normal in the other tissues. 10487692 1999
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 GeneticVariation disease BEFREE TG and TPO were identified in 13 patients (54.2%) with thyroid carcinoma, which includes five of eight patients with no clinical evidence of disease at the time of blood collection. 9508203 1998
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 AlteredExpression disease BEFREE TPO mRNA expression in differentiated thyroid carcinomas did not always correlate with the mRNA expression of thyroglobulin, thyroid stimulating hormone receptor, and thyroid transcription factor 1. 8691351 1996
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE This paper reports the results of research to examine the possibility of using the differential expression of two enzymes, dipeptidyl peptidase IV (DPPIV/CD26, EC: 3.4.14.5) and thyroid peroxidase (TPO, EC: 1.11.1.7), as histochemical markers histopathologically to diagnose thyroid carcinomas. 8732452 1996
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 AlteredExpression disease BEFREE With various degrees of expression, all differentiated thyroid carcinomas (20 papillary and 2 follicular) expressed TSH-R, Tg, and TPO, but not CT mRNAs. 8157713 1994
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 AlteredExpression disease BEFREE TPO expression is lost in several thyroid carcinoma cell lines (TPC-1, 8305C, 8505C) and altered in another (TC-80). 8117301 1994