Thyroid carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TPO genetic variants may be associated with thyroid carcinoma and hypoechoic thyroid nodules in a few cases.
|
26406404 |
2015 |
Thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations in the TPO gene are common in congenital hypothyroidism, and there are also signs of the implication of TPO in thyroid cancer.
|
23754668 |
2013 |
Thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cotransduction of TTF-1 and Pax-8 gene, with resulting NIS-mediated radioiodine accumulation and TPO and Tg-mediated radioiodine organification and intracellular retention, may lead to effective radioiodine therapy of thyroid carcinoma.
|
22498723 |
2012 |
Thyroid carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that Pax-8 can promote iodide uptake, and specifically prolong the retention time of iodide in thyroid cancer in vitro and in vivo by promoting the expression of TPO and Tg proteins.
|
21833035 |
2012 |
Thyroid carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The occurrence of thyroid carcinoma in patients with congenital hypothyroidism (CH) caused by dyshormonogenesis is very rare, and has only been reported in one patient harboring mutations in the thyroid peroxidase (TPO) gene.
|
22435912 |
2012 |
Thyroid carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF(V600E) mutation, in both primary and metastatic thyroid cancers, is associated with a marked drop in thyroperoxidase (29-fold) and pendrin (20-fold) expression and a considerable increase (five-fold) in GLUT-1 expression.
|
17854396 |
2008 |
Thyroid carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results confirmed the decrease of TPO expression in 97% of thyroid carcinomas regardless of histological type and the overexpression of shorter splice variants in follicular tumors.
|
16728576 |
2006 |
Thyroid carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As individuals with goitrous hypothyroidism caused by TPO gene mutation develop thyroid cancer, regular and careful follow-up for such patients must be done.
|
16284446 |
2005 |
Thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Natural flavonoids (plant pigments) have been shown to inhibit thyroid peroxidase (TPO) in vitro and the growth of thyroid cancer cell lines.
|
15080787 |
2004 |
Thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Qualitative analysis of baseline and stimulated TG, NIS and PDS mRNA showed high sensitivity but low specificity in the prediction of thyroid cancer recurrence or metastases (accuracy under THST = 51%, 43% and 54%, respectively), whereas TPO and TSHR mRNA assays had higher specificity but low sensitivity, with accuracy under THST of 67% and 61%, respectively, that improved when these tests were combined.
|
15170676 |
2004 |
Thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Iodination of proteins in TPO transfected thyroid cancer cells is independent of NIS.
|
15062578 |
2003 |
Thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TPO transcripts were detected in 7/10 (70%) patients with known metastases of thyroid cancer and in 39 of 110 (36%) patients without metastases (P<0.05), in 15/44 (34%) patients with goitre, in 17/41 (41%) cases with GD and in 4/54 (7.4%) subjects in the control group (P<0.05, controls vs all patients with thyroid disease).
|
12459031 |
2002 |
Thyroid carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results confirm that TPO is expressed in thyroid carcinomas but in smaller amounts than in normal tissue and benign tumors.
|
10718546 |
2000 |
Thyroid carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TPO expression was decreased in thyroid carcinomas, but was normal in cold adenomas; it was increased in toxic adenomas and Graves' thyroid tissues Tg expression was decreased in thyroid carcinomas, but was normal in the other tissues.
|
10487692 |
1999 |
Thyroid carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TG and TPO were identified in 13 patients (54.2%) with thyroid carcinoma, which includes five of eight patients with no clinical evidence of disease at the time of blood collection.
|
9508203 |
1998 |
Thyroid carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TPO mRNA expression in differentiated thyroid carcinomas did not always correlate with the mRNA expression of thyroglobulin, thyroid stimulating hormone receptor, and thyroid transcription factor 1.
|
8691351 |
1996 |
Thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This paper reports the results of research to examine the possibility of using the differential expression of two enzymes, dipeptidyl peptidase IV (DPPIV/CD26, EC: 3.4.14.5) and thyroid peroxidase (TPO, EC: 1.11.1.7), as histochemical markers histopathologically to diagnose thyroid carcinomas.
|
8732452 |
1996 |
Thyroid carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
With various degrees of expression, all differentiated thyroid carcinomas (20 papillary and 2 follicular) expressed TSH-R, Tg, and TPO, but not CT mRNAs.
|
8157713 |
1994 |
Thyroid carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TPO expression is lost in several thyroid carcinoma cell lines (TPC-1, 8305C, 8505C) and altered in another (TC-80).
|
8117301 |
1994 |