TPO, thyroid peroxidase, 7173

N. diseases: 306; N. variants: 47
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE Green coffee, green tea, cumin, and mustard contain potentially bioaccessible TPO activators that also act as effective LOX inhibitors, which indicate their potentially health-promoting effects for people suffering from Hashimoto's disease. 31671724 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE A diagnosis of autoimmune thyroiditis (AT) in thyrotoxic phase was made on the basis of clinical presentation and presence of anti-TPO antibodies and reduced uptake in thyroid (technetium) scintigraphy. 30128632 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE Conclusions Fluctuating thyroid function tests in addition to thyroid peroxidase antibody (TPO Ab) positivity complicated the diagnosis of RTH, initially diagnosed as Hashimoto's thyroiditis. 30681972 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE Our key and novel finding is the existence of significant positive correlation between TgAb levels and the number of symptoms (r = 0.25, p = 0.0001) in HT patients without LT4 therapy that remained significant after adjustment for TPOAb, T3, TSH levels and thyroid volume (β = 0.66, SE = 0.3, p = 0.0299). 30332318 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE Autoimmunity to TPO is characterised by autoantibodies and T cell reactivity in Hashimoto's disease and Graves' disease. 30742860 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE This study included 933 patients with thyroid peroxidase antibodies (anti-TPO-Ab) ≥34 kIU/l, including most patients with clear AIT due to a concurrent sonographic evidence of reduced echogenicity. 31766063 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE Antibodies to thyroid peroxidase (TPO), the enzyme that catalyses thyroid-hormone production and antibodies to the receptor for the thyroid-stimulating hormone, are characteristic of HT and GD, respectively. 30208979 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE The prevalence of anti thyroperoxidase (TPO) was significantly increased in the autoimmune thyroiditis (AIT). 30807792 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE Thyroid dysfunction (TD) is caused by thyroid peroxidase (TPO) antibody, as seen in Hashimoto's disease. 31776300 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 AlteredExpression disease BEFREE This clinical trial was designed to investigate the impact of Se and vitamin C supplementation on antithyroid peroxidase antibody (TPO-Ab) level in patients with AIT. 30182359 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE Thyroid antibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) are key markers of Hashimoto's thyroiditis (HT), the most common autoimmune thyroid disorder. 30926877 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE In those with HT, MMP-3 correlated negatively with FT3 (rho=-0.545, P=0.048) and positively with TPO-Ab and HI (rho=0.735, P=0.02; rho=0.769, P=0.01, respectively). 29442475 2018
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE The aim of the present study was to explore the effect of Se on thyroid peroxidase antibody (TPOAb) titers in patients with AIT and to analyze a potential impact of the genetic background on the effect of Se supplementation Methods Randomized, placebo-controlled, double-blind trial. 30398407 2018
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 AlteredExpression disease BEFREE Most importantly, only Tfh17 cell percentages were positively correlated with anti-thyroglobulin and anti-thyroid peroxidase antibody levels and were negatively correlated serum free T3 and free T4 levels in HT patients. 30345813 2018
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE Thyroid Peroxidase as an Autoantigen in Hashimoto's Disease: Structure, Function, and Antigenicity. 30360003 2018
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE We identified all studies that assessed the changes of TPO-Ab and Tg-Ab in patients with AIT under the treatment of vitamin D from PubMed, Embase, The Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and VIP Database. 29388046 2018
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE To study the prevalence of Hashimoto thyroiditis (HT), anti-thyroid autoantibodies (anti-thyroglobulin or TgAb and thyroperoxidase or TPOAb) in systemic lupus erythematosus (SLE) patients. 28544477 2018
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 GeneticVariation disease BEFREE We experienced a 6-year-old case of drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) with subsequent development autoimmune thyroiditis (Hashimoto's thyroiditis), type 1 diabetes with antithyroglobulin, thyroid peroxidase, insulinoma-associated antigen and anti-insulin antibodies at 4 months, alopecia at 7 months, vitiligo, uveitis due to Vogt-Koyanagi-Harada disease at 8 months after clinical resolution of the DiHS/DRESS. 30368475 2018
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 GeneticVariation disease BEFREE The aim of this study was to evaluate cognitive function and quality of life (QoL) in patients on long-term levothyroxine replacement for HT in relation to thyroid function tests and TPO (thyroid-peroxidase) antibody (TPOAb) status. 29959689 2018
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE The percentage positive for thyroid peroxidase (TPO) antibody and lymphocytic thyroiditis was significantly higher in the TgAb-positive group. 28493284 2017
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE In our study, prevalence of TPO-Ab positivity is more frequent in subjects with <i>H. pylori</i> infection.Our findings suggest <i>H. pylori</i> infection may play a role in the development of autoimmune thyroiditis. 28092700 2017
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE Only data from patients with laboratory-confirmed HT (anti-thyroid peroxidase [anti-TPO] antibodies; thyroglobulin antibodies; serum thyroid-stimulating hormone; and free T3) were eligible for inclusion. 28217937 2017
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE In FNAC studies, the association between HT and PTC is based on the comparison of anti-thyroid autoantibodies (ATA) (anti-thyroperoxidase [TPOAb] and anti-thyroglobulin [TgAb]), thyroid function (TSH), and cytology with histology of thyroid nodules and lymphocytic thyroid infiltration (LTI) of operated thyroid glands. 28868258 2017
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 AlteredExpression disease BEFREE The procalcitonin and anti-thyroid peroxidase levels were identified to be an independent predictor in diagnosis of Hashimoto's thyroiditis. 28171686 2017
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease
0.100 Biomarker disease BEFREE Instead, our finding that low dietary Se potentiates the development of autoantibodies to Tg and TPO in females is consistent with reports in humans of an increased prevalence of autoimmune thyroiditis in low-Se regions. 28938453 2017