TRAF3, TNF receptor associated factor 3, 7187

N. diseases: 129; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis
0.530 Biomarker disease BEFREE Autosomal recessive (AR) UNC-93B and TLR3 deficiencies and autosomal dominant (AD) TLR3 and TRAF3 deficiencies underlie HSE in some children. 22105173 2011
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis
0.530 GeneticVariation disease BEFREE The narrow disorders impair exclusively (TLR3) or mostly (UNC-93B, TRIF, TRAF3) the TLR3-dependent induction of type I and III IFNs, leading to HSE in apparently otherwise healthy individuals. 22347990 2011
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis
0.530 Biomarker disease BEFREE Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. 20832341 2010
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis
0.530 SusceptibilityMutation disease ORPHANET Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. 20832341 2010
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis
0.530 Biomarker disease CTD_human