|
Herpes encephalitis
|
0.530 |
Biomarker
|
disease |
BEFREE |
Autosomal recessive (AR) UNC-93B and TLR3 deficiencies and autosomal dominant (AD) TLR3 and TRAF3 deficiencies underlie HSE in some children.
|
22105173 |
2011 |
|
Herpes encephalitis
|
0.530 |
GeneticVariation
|
disease |
BEFREE |
The narrow disorders impair exclusively (TLR3) or mostly (UNC-93B, TRIF, TRAF3) the TLR3-dependent induction of type I and III IFNs, leading to HSE in apparently otherwise healthy individuals.
|
22347990 |
2011 |
|
Herpes encephalitis
|
0.530 |
Biomarker
|
disease |
BEFREE |
Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.
|
20832341 |
2010 |
|
Herpes encephalitis
|
0.530 |
SusceptibilityMutation
|
disease |
ORPHANET |
Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.
|
20832341 |
2010 |
|
Herpes encephalitis
|
0.530 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 5
|
0.500 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
TRAF3 regulates the effector function of regulatory T cells and humoral immune responses.
|
24378539 |
2014 |
|
Herpetic meningoencephalitis
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.
|
20832341 |
2010 |
|
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 5
|
0.500 |
GeneticVariation
|
disease |
UNIPROT |
Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.
|
20832341 |
2010 |
|
Herpetic meningoencephalitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Herpetic Acute Necrotizing Encephalitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Multiple Sclerosis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Stimulation of the CD40 pathway by CD40L reduced LCL proliferation (p < 0.001), dependent on CD40 and TRAF3 MS risk genotypes.
|
31039804 |
2019 |
|
Multiple Sclerosis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Specific deletion of the tumor suppressor TRAF3 from B lymphocytes in mice leads to the prolonged survival of mature B cells and expanded B cell compartments in secondary lymphoid organs.
|
31826940 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Combination treatment of TRAF3-deficient B cells and B cell tumor lines with c-Myc inhibitors enhanced their sensitivity to Pim inhibition, suggesting a possible therapeutic strategy.
|
31501481 |
2019 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Biliary calculi
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Variants in ABCG8 and TRAF3 genes confer risk for gallstone disease in admixed Latinos with Mapuche Native American ancestry.
|
30692554 |
2019 |
|
Childhood asthma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It is thus perhaps not surprising that TRAF3 has been revealed as an important tumor suppressor in B cells.
|
30319624 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we report that TRAF3-deficient HPV<sup>+</sup> tumors and cell lines exhibit increased expression of alternative NF-κB pathway components and transcription factors NF-κB2/RELB.
|
29921694 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mice genetically engineered to have TRAF3 deleted in osteoclast precursors and macrophages develop early onset osteoporosis, inflammation in multiple tissues, infections, and tumors, indicating that TRAF3 suppresses inflammation and tumors in myeloid cells.
|
30323820 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, immunohistochemical staining and survival analyses of a gastric cancer tissue microarray revealed that TRAF3 functioned as a tumor suppressor in gastric cancer.
|
30226589 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previous studies showed that TRAF3 overexpression renders B cells hyper-reactive to antigens and Toll-like receptor (TLR) agonists, while TRAF3 deficiency has been implicated in the development of a variety of B cell neoplasms.
|
30687320 |
2018 |