TRH, thyrotropin releasing hormone, 7200

N. diseases: 230; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 Biomarker group BEFREE Two hypertension cohorts were examined-new antihypertensive drug users (incident hypertension) and patients requiring titration to a fourth antihypertensive (incident treatment-resistant hypertension [TRH]). 30052747 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 Biomarker group BEFREE Following injection in rodents, TRH has multiple effects including increased blood pressure and breathing. 29674333 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 Biomarker group RGD Thus the TRH-leptin interaction may contribute to the strong association between hypertension and obesity. 17227965 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 GeneticVariation group BEFREE Five polymorphisms in five genes, CAST(calpastatin), LIPC (hepatic lipase), SLC4A1 (band 3 anion transporter), TRH (thyrotropin-releasing hormone), and VWF (von Willebrand factor), were significantly associated with both blood pressure variation and hypertension. 17137217 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 Biomarker group BEFREE As it has been demonstrated that hypertensive patients have a blunted TSH response to TRH injection, suggesting a defect in the TRHR, we postulate that the TRHR gene is involved in human hypertension. 11566956 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 Biomarker group BEFREE To summarize, central TRH overproduction in periventricular areas induced by I.C.V. transfection produces hypertension in rats which is reversed by specific antisense treatment. 9323019 1997
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 Biomarker group CTD_human In addition, intraventricular administration of TRH, LHRH or LH caused tachycardia, hypertension and a reduction in the epinephrine-induced reflex bradycardia. 6350720 1983